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The Cost Of Creating A New Drug Now $5 Billion, Pushing Big Pharma To Change

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Susan Desmond-Hellmann

There’s one factor that, as much as anything else, determines how many medicines are invented, what diseases they treat, and, to an extent, what price patients must pay for them: the cost of inventing and developing a new drug, a cost driven by the uncomfortable fact than 95% of the experimental medicines that are studied in humans fail to be both effective and safe.

A new analysis conducted at Forbes puts grim numbers on these costs. A company hoping to get a single drug to market can expect to have spent $350 million before the medicine is available for sale. In part because so many drugs fail, large pharmaceutical companies that are working on dozens of drug projects at once spend $5 billion per new medicine.

read all at

http://www.forbes.com/sites/matthewherper/2013/08/11/how-the-staggering-cost-of-inventing-new-drugs-is-shaping-the-future-of-medicine/

How Much They Cost: R&D Spending Per New Drug

Company Number of new drugs 10 year R&D spending ($MIL) R&D per drug ($MIL)
1 Abbott 1 13183 13183
2 Sanofi 6 60768 10128
3 AstraZeneca 4 38245 9561
4 Hoffmann-La Roche 8 70928 8866
5 Pfizer 10 77786 7779
6 Wyeth 3 22702 7567
7 Eli Lilly 4 26710 6678
8 Bayer 5 33118 6624
9 Schering-Plough 3 18845 6282
10 Novartis 10 60727 6073
11 Takeda 4 24132 6033
12 Merck&Co 9 49133 5459
13 GlaxoSmithKline 11 57595 5236
14 J&J 13 67624 5202
15 Novo Nordisk 2 9251 4625
16 UCB 1 4325 4325
17 Yamanouchi 1 4321 4321
18 Fujisawa 1 4286 4286
19 Amgen 5 21350 4270
20 Astellas 3 12582 4194
21 Shionogi 1 3854 3854
22 Celgene 2 7193 3596
23 Bristol-Myers Squibb 9 30352 3372
24 Eisai 4 11534 2883
25 Teva 2 5763 2881
26 Biogen Idec 4 9470 2368
27 Vertex 2 4140 2070
28 Sunovion 1 1967 1967
29 Human Genome Sciences 1 1954 1954
30 Elan 1 1903 1903
31 Gilead 3 5527 1842
32 Exelixis 1 1789 1789
33 Lundbeck 2 3527 1763
34 Millennium 1 1593 1593
35 Genentech 4 6277 1569
36 Allergan 1 1559 1559
37 Baxter 3 4627 1542
38 Ipsen 1 1459 1459
39 Forest 4 5184 1296
40 Cephalon 1 1221 1221
41 Onyx 1 1219 1219
42 Sepracor 1 1170 1170
43 Alcon 1 1133 1133
44 Theravance 1 1010 1010
45 Genzyme 5 4814 963
46 Shire 4 3827 957
47 Arena 1 934 934
48 Watson 1 930 930
49 Adolor 1 877 877
50 Valeant 1 844 844
51 Schwarz 2 1545 772
52 NPS 1 756 756
53 Regeneron 3 2149 716
54 Affymax 1 660 660
55 Seattle Genetics 1 610 610
56 CV Therapeutics 1 599 599
57 ImClone 1 517 517
58 Dendreon 1 509 509
59 Alexion 1 490 490
60 The Medicines Company 1 455 455
61 Ariad 1 444 444
62 OSI 1 402 402
63 Talecris 1 396 396
64 Progenics 1 356 356
65 Actelion 1 346 346
66 Savient 1 339 339
67 Praecis 1 311 311
68 Vivus 1 309 309
69 MGI 1 294 294
70 Vicuron 1 286 286
71 Salix 2 560 280
72 Idenix 1 280 280
73 Mylan 3 762 254
74 Discovery Laboratories 1 228 228
75 Indevus 1 222 222
76 Cubist 1 220 220
77 Acorda 1 185 185
78 Ista 1 171 171
79 Optimer 1 171 171
80 Theratechnologies 1 164 164
81 MediGene 1 155 155
82 Vanda 1 150 150
83 Eyetech 1 144 144
84 ThromboGenics 1 137 137
85 BioMarin 3 403 134
86 Protalix 1 125 125
87 Amarin 1 122 122
88 Insmed 1 118 118
89 NeurogesX 1 89 89
90 Hyperion 1 87 87
91 Cypress Bioscience 1 82 82
92 New River 1 79 79
93 Aegerion 1 74 74
94 Sucampo 1 62 62
95 Fibrocell 1 62 62
96 Tercica 1 49 49
97 Pharmion 1 47 47
98 Kamada 1 37 37
99 Lev 1 26 26
100 OMRIX 1 15 15
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DR ANTHONY CRASTO

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 29 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 29 year tenure till date Aug 2016, Around 30 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 25 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 13 lakh plus views on New Drug Approvals Blog in 212 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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