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DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

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ORGANIC SPECTROSCOPY

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 30 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. Radhakrishnan and Dr B. K. Kulkarni, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 30 year tenure till date Dec 2017, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 50 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 19 lakh plus views on New Drug Approvals Blog in 216 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus


Sreeni Labs Private Limited

SREENI LABS CONTRIBUTION
Customer requested Sreeni Labs to make BL001 first on  few mg scale. Sreeni labs synthesized and supplied in a short time with full characterization data. Later, customer requested us to make it on several gram scale and we synthesized and delivered as custom synthesis project.

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

NATURE COMMUNICATIONS | (2018) 9:1488 |DOI: 10.1038/s41467-018-03943-0 | http://www.nature.com/naturecommunications

Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by
immune cells. Current therapies focused on repressing the immune attack or stimulating beta
cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative
targets to dampen the immune process, while promoting beta cell survival and function. Liver
receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive
organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small
LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation
of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic
patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1
agonism favors a dialogue between immune and islet cells, which could be druggable to
protect against diabetes mellitus.

 

//////////////SREENI LABS

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Doglovers, Various types of food can actually be fatal for dogs due to a common, all natural sweetener called xylitol (yikes).


Tis the season for snowball fights, Christmas decorations, and food – SO MUCH FOOD. If you celebrate Christmas (or Hanukkah), chances are you’ll be indulging this holiday season. While I fully support everyone’s right to treat themselves, a lot of kids (and parents) don’t realize that various types of food can actually be fatal for dogs due to a common, all natural sweetener called xylitol (yikes). Because I’m a dog lady, I compiled a list of products that contain xylitol for dog owners to refer to!

https://simplewag.com/xylitol-dogs-a/

 

Xylitol is a sugar alcohol commonly used in candy and chewing gum (and some other products, such as peanut butter.) It is also found in some pharmaceuticals and oral health products such as chewable vitamins and throat lozenges. While Xylitol is safe for humans, xylitol and dogs do not mix. The compound doesn’t affect glucose levels in people, but when ingested by dogs it can cause a dangerous surge of insulin. (In as little as 15 minutes, the blood sugar of a dog that has eaten gum containing Xylitol may register a marked drop in blood sugar.) At higher doses, Xylitol is believed toxic to the canine liver.

Xylitol and Dogs: Statistics

In the past 5 years, Pet Poison Helpline, an animal poison control based out of Minneapolis, MN, has had over 1500 calls for xylitol poisoning, due to the growing awareness of this common kitchen toxin. In both humans and dogs, the level of blood sugar is controlled by the release of insulin from the pancreas. Xylitol does not stimulate the release of insulin from the pancreas in humans.

However, when non-primate species (e.g.,  a dog) eat something containing xylitol, the xylitol is quickly absorbed into the bloodstream, resulting in a potent release of insulin from the pancreas.  This rapid release of insulin results in a rapid and profound decrease in the level of blood sugar (hypoglycemia), an effect that occurs within 10-60 minutes of eating the xylitol. Untreated, this hypoglycemia can be life-threatening.It can also be used in home baking.

Just three grams of Xylitol can kill a 65-pound dog. Because the amount of sweetener used in sugar-free chewing gums varies by manufacturer and product, the number of sticks of gum that would prove fatal to a pooch of that size can’t be stated with precision. As a general rule of thumb, between eight and ten pieces of gum might be deadly to a 65-pound canine, but a smaller dog could easily die after ingesting far less (perhaps as few as two sticks of gum).

If you suspect that your pet has eaten a xylitol-containing product, please contact your veterinarian or Pet Poison Helpline (800-213-6680) immediately. Do not induce vomiting or give anything orally to your dog unless specifically directed to do so by your veterinarian. It is important to get treatment for your dog as quickly as possible.  As some dogs may already be hypoglycemic, inducing vomiting can make them worse!

Xylitol & Dogs: Symptoms

Symptoms of xylitol toxicity develop rapidly, usually within 15-30 minutes of consumption. Signs of hypoglycemia may include any or all of the following:

  • Vomiting
  • Weakness
  • Incoordination or difficulty walking or standing (walking like drunk)
  • Depression or lethargy
  • Tremors
  • Seizures
  • Coma

In severe cases, the dog may develop seizures or liver failure. Dogs that develop liver failure from xylitol poisoning often show signs of hypoglycemia.

Xylitol & Dogs: Diagnosis

A presumptive diagnosis of xylitol poisoning is made if there is a known or possible history that the dog ate something containing xylitol, coupled with symptoms of hypoglycemia. Since toxicity develops rapidly, your veterinarian will not wait for a confirmed diagnosis before beginning treatment. There is no antidote for xylitol toxicity, although treatment with sugar supplementation, IV fluids, and liver protective drugs are beneficial.

Xylitol & Dogs: Treatment

Fast and aggressive treatment by your veterinarian is essential to effectively reverse any toxic effects and prevent the development of severe problems. If your dog has just eaten xylitol but has not yet developed any clinical signs, your veterinarian may induce vomiting to prevent further absorption, depending on what your dog’s blood glucose level is. If clinical signs have developed, treatment will be based on the symptoms that are being shown.

Since xylitol toxicity can cause both low blood glucose and low potassium levels, your veterinarian will perform blood work to determine whether these problems need to be treated. In all cases, your dog will require hospitalization for blood sugar monitoring, dextrose administration, intravenous fluids, liver protectants, and any other supportive care that may be needed. Blood work should be monitored frequently to make sure that blood sugar and liver function remain normal.

Xylitol & Dogs: Prognosis

The prognosis is good for dogs that are treated before symptoms develop, or for dogs that develop uncomplicated hypoglycemia that is reversed rapidly. If liver failure or a bleeding disorder develops, the prognosis is generally poor. If the dog lapses into a coma, the prognosis is very poor. If you personally use products containing xylitol, make sure they are stored safely, out of reach of your pets. Do not share any food that may contain xylitol with your pets. Only use pet toothpaste for pets, never human toothpaste. Keep in mind that there are some veterinary products that contain small amounts of xylitol (e.g., gabapentin medication, mouthwashes). At prescribed doses, these should not result in xylitol poisoning; however, if ingested in large amounts, can potentially result in poisoning.

Xylitol In Products

Many people start a new year with a plan to live a healthier life. But, unbeknownst to some dog owners, a common sugar additive that is used in reduced sugar and diet products has the ability to be lethal to their pup. That sugar additive is called xylitol.

Xylitol is a sugar alcohol commonly used in candy and chewing gum (and some other products, such as peanut butter.) It is also found in some pharmaceuticals and oral health products such as chewable vitamins and throat lozenges.

While Xylitol is safe for humans, it can be harmful to dogs!!

Here is a list of the known products that contain xylitol.

Xylitol In Products: Peanut Butter

Xylitol product list sorted alphabetically by company or distributor
Go Nuts, Co.
Almond Butter
Almond Butter – Chocolate Almond Butter
Peanut Butter – Dark Chocolate Mint
Peanut Butter – Natural Chocolate Flavor
Peanut Butter – Natural Flavor
Peanut Butter – Organic Maple Flavor
Krush Nutrition
Nutty By Nature Peanut Butter Brownie Batter
Nutty By Nature Peanut Butter Cookie Dough
Nutty By Nature Peanut Butter Snickerdoodle Cookie
Nutty By Nature Peanut Butter Thick & Creamy
Nuts ‘N More®
Almond Spread – Almond Butter
High Protein + Almond Spread – Almond Butter
High Protein + Almond Spread – Chocolate Almond
High Protein + Almond Spread – Cinnamon Raisin
High Protein + Peanut Spread – Chocolate Peanut
High Protein + Peanut Spread – Peanut Butter Flavor
High Protein + Peanut Spread – Pumpkin Spice
High Protein + Peanut Spread – Toffee Crunch
Peanut & Protein Spread – Sesame Cranbutter
Peanut Spread – Peanut Butter Flavor
Peanut Spread – Toffee Crunch
P28 Foods
High Protein Spread – Almond Butter
High Protein Spread – Banana Raisin
High Protein Spread – Peanut Spread
High Protein Spread – Signature Blend
Protein Plus PB
Hank’s Protein Plus – Almond Butter
Hank’s Protein Plus – Banana
Hank’s Protein Plus – Caramel Pretzel
Hank’s Protein Plus – Chocolate Chip
Hank’s Protein Plus – Coconut
Hank’s Protein Plus – Honey Maple
Hank’s Protein Plus – Plain
Hank’s Protein Plus – Snickerdoodle

Xylitol In Products: Chocolate

Xylitol product list sorted alphabetically by company or distributor
 Avalon Select
Tru Chocolate – Assorted Flavors
Bulletproof™ 
Chocolate Fuel Bars – Assorted Flavors
Truffled Chocolate Coffee Beans
Dr. John’s
Gourmet Chocolates: Cool Mint, Creamy Peanut Butter, Exotic Coconut, Pecan Caramel Perfection Bars, Pecan Caramel Perfection Clusters, Raspberry Rapture, Sea Salt Caramel, Signature Sampler Collection, Toasted Toffee with Almonds
Healthy Chocolate Co, Inc
Health 4Living™ Xylitol COQ10 Chocolate
Healthy Chocolate – Dark Assorted, Dark Coffee, Dark Coconut, Dark Mint, Dark Orange, Dark Plain, Dark Raspberry
The Raw Chocolate Co
Mint Raw Chocolate
Orange Raw Chocolate

 Xylitol In Products: Cookies, Desserts, Mixes, Ice Cream & Yogurt

Xylitol product list sorted alphabetically by company or distributor

Barry Farm
Sugar Free Pie Filling – Assorted Flavors

Clemmy’s™ Ice Cream
Clemmy’s Rich and Creamy Ice Cream – Chocolate, Chocolate Chip, Orange Creme, Toasted Almond, Vanilla Bean, Coffee
Clemmy’s Rich and Creamy Bars – Cherry Vanilla, Chocolate Fudge, Orange Creme, Strawberries ‘N Creme
Health Garden
Kosher Choc-Oh-Chip Cookies
Jell-O
Jell-O – Boston Cream Pie Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Dulce de leche Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Chocolate Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Chocolate Vanilla Swirls Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Dark Chocolate Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Double Chocolate Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Chocolate Indulgence Mousse Sugar Free
Jell-O – Dark Chocolate Decadence Mousse Sugar Free
Jell-O – Creme Brûlée Rice Pudding Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Rice Pudding Sugar Free / Reduced Calorie Pudding Snacks
Jell-O – Vanilla Sugar Free / Reduced Calorie Pudding Snacks
Sophie Yogurt
Non-Fat Greek Yogurt – Assorted Flavors
SweetDeliverance™
B-Sugarless – Diabetic Cake Mixes – Assorted Flavors
Wegmans
Sugar Free Pudding: Chocolate, Chocolate Vanilla Swirl
Sugar Free Pudding with Calcium : Dark Chocolate
Wheyhey 
Protein Ice Cream – Assorted Flavors

Xylitol In Products: Jams & Syrups

Xylitol product list sorted alphabetically by company or distributor

Focus Nutrition
XyloBurst Sugar-Free Jam: Apricot, Blueberry, Mountain Berry, Peach, Raspberry, Strawberry
Nature’s Hollow
Apricot Sugar-Free Jam Preserves
Blueberry Sugar-Free Jam Preserves
Mountain Berry Sugar-Free Jam Preserves
Peach Sugar-Free Jam Preserves
Raspberry Sugar-Free Jam Preserves
Strawberry Sugar-Free Jam Preserves
Wild Blueberry Sugar-Free Jam Preserves
Maple Sugar-Free Syrup
Raspberry Sugar-Free Syrup
Xylabrands
Xyla Jam – Apricot, Blueberry, Mountain Berry, Peach, Raspberry, Strawberry

 Xylitol in Products- Condiments & Sauces

Xylitol product list sorted alphabetically by company or distributor

Health Garden
Sugar-Free Tomato Ketchup
Nature’s Hollow
Sugar Free Hickory Maple BBQ Sauce
Sugar Free Honey Mustard BBQ Sauce
Sugar-Free Ketchup
Xylabrands
Xyla BBQ Sauce – Original
Xyla Buffalo Wing Sauce
Xyla Chipotle BBQ Sauce
Xyla Ketchup
Xyla Sesame Teriyaki Sauce

Xylitol In Products: Water & Drink Powders

Xylitol product list sorted alphabetically by company or distributor
Designs For Health 
Electrolyte Synergy Grape Flavor
Natural Factors®
SlimStyles® Weight Loss Drink with PGX® – Assorted Flavors
NOW® Foods
Berry Lemonade Slender Sticks
Berry Energy Tea Slender Sticks
Effer-C™ Acai Berry Sticks
Effer-C™ Cranberry Pomegranate Packets
Effer-C™ Elderberry Packets
Grape Slender Sticks
Pomegranate Berry Slender Sticks
Natural Max (no website found)
Skinny Fast Hunger Rescue Chocolate Fix
xyWater
xyWater Nutritional Drink – Assorted Flavors
ZipFizz®
Energy Drink Mix – Assorted Flavors
Immune Fizz – Fruit Punch

Xylitol In Products: Power & Protein Bars, and Powders

Xylitol product list sorted alphabetically by company or distributor

Betty Lou’s™
Low Glycemic Protein Shake: Chocolate, Orange Cream, Vanilla

Designs For Health
PaleoBar Chocolate Coated

Life Extension® 
Pure Plant Protein

NOW® Foods
Berry Lemonade Slender Sticks
Berry Energy Tea Slender Sticks
Effer-C™ Acai Berry Sticks
Effer-C™ Cranberry Pomegranate Packets
Effer-C™ Elderberry Packets
Grape Slender Sticks
Pomegranate Berry Slender Sticks

Natural Max (no website found)
Skinny Fast Hunger Rescue Chocolate Fix

Protocol For Life Balance® 
Plant Protein Complete

Renew Life 
FitSMART Shake – Assorted Flavors
FitSMART Vegan Shake – Assorted Flavors

Xylitol In Products: Candies, Gum & Mints

Xylitol product list sorted alphabetically by company or distributor

Bach Flower
Rescue® Chewing Gum – Orange & Elderflower
Rescue® Pastilles – Assorted Flavors

B Fresh®
B Fresh Energy Mints – Assorted Flavors
B Fresh® Gum – Assorted Flavors

Branam™
Branam™ Xylitol Gum – Hot Cha Cha Cinnamon, Snappy Apple

Designs For Health
Brain Power Sours

Camellix™
MighTeaFlow® Dry Mouth Chewing Gum
MighTeaFlow® Dry Mouth Gel
MighTeaFlow® Dry Mouth Moisturizing Lozenges
MighTeaFlow® Dry Mouth Moisturizing Oral Rinse
MighTeaFlow® Dry Mouth Moisturizing Oral Spray
MighTeaFlow® Green Tea Lozenges

Carifree®
CTx1 Lollies
CTx2 Xylitol Gum

Cleure™
Cleure Fresh Fruit Gum
Cleure Lemon Drops

Cracked Candy™
Cracked Candy – Assorted Flavors

CVS Pharmacy®
CVS Sugar Free Breath Strips Blue Mint

Dentyne®
Dentyne Pure Mint With Citrus Accents
Dentyne Pure Mint With Herbal Accents
Dentyne Pure Mint With Melon Accents

Dr. John’s
Hard Candy: Butterscotch Bliss, Cafe Caramel, Cherry Blossom, Classic Fruits Collection, Cream Soda, Creamsicle Swirl Collection, Fresh Fruits Collection, Luscious Licorice, Mighty Mango, Peppermint Pop, Perfect Pear, Pink Grapefruit, Radiant Rainbow, Signature Sours Collection, Sour Cherry, Sour Lemon, Strawberry Cheesecake, Sunkissed Fruits Collection, Ultimate Hard Candy Collection, Ultimate Sweets Collection

Lollipops: Blue Raspberry Blast, Butterscotch Bliss, Cheeky Cherry, Classic Fruits Collection, Classic Fruits Collection, Creamsicle Swirl Collection, Fresh Fruits Collection, Juicy Grape, Peppermint Pop, Pomegranate Punch, Proudly Patriotic, Radiant Rainbow, Signature Sours Collection, Sunkissed Fruits Collection, Ultimate Lollipop Collection, Ultimate Sweets Collection, Whimsical Watermelon

Soft Candies: Butter Crunch Caramels, Butterscotch Bliss Caramels, Cafe Caramel Caramels, Caramel Lovers Collection, Chocolate Caramel Swirls, Luscious Licorice Taffy, Peppermint Pop Taffy, Ultimate Sweets Collection, Vanilla Caramel Swirls

Sweet Advantage™ Gum – Fruit Punch
Sweet Advantage™ Gum – Peppermint Pop
Sweet Advantage™ Tablet: Peppermint Pop™
Sweet Advantage™ Tablet: Tangy Melon™

Eco-Dent®
Between! Dental Gum – Assorted Flavors

Epic Dental
Xylitol Gum: Cinnamon, Fresh Fruit, Peppermint, Spearmint
Xylitol Mints: Peppermint, Fresh Fruit, Cinnamon

Extra Ice (Wrigley’s)
Extra® Ice – Spearmint
Extra® Ice – Peppermint

Focus Nutrition
XyloBurst Gum: Cinnamon, Fruit, Green Tea, Peppermint, Spearmint,
XyloBurst Xylitol Mints: Berry, Cinnamon, Ginger, Lemon, Licorice, Peppermint, Wintermint
XyloBurst Xylitol Fruit Sours: Cherry, Grape, Orange Citrus, Lemon Lime, Peach Sour, Watermelon
XyloBurst Sugar Free Lollipops with Xylitol: Apple, Orange, Raspberry, Strawberry

Glee Gum
Sugar-Free Glee Gum: Lemon-Lime, Refresh-Mint, Wild Watermelon

Hager Pharma
Hager Pharma Miradent Chewing Gum: Cinnamon, Cranberry, Fresh Fruit, Green Tea, Peppermint, Spearmint

Healthy Grid
Tooth Friendly Xylitol Candies – Assorted Flavors

Hersheys®
Ice Breakers® – Cool Blasts Gum – Assorted Flavors
Ice Breakers® – Ice Cubes Gum – Assorted Flavors

Ice Chips Candy
Ice Chips – Assorted Flavors

Juicy Fruit (Wrigley’s)
Juicy Fruit Fruity Chews – Original

Lotte Confectionery
Lotte Xylitol Gum – Assorted Flavors
Lotte Xylitol Alpha Project Gum – Assorted Flavors
Anytime Candy – Assorted Flavors

Melaleuca
Exceed™ Gum – Assorted Flavors
Exceed™ Mints – Assorted Flavors

Mentos®
Mentos® Pure Gum – Assorted Flavors
Mentos® SugarFree Gum – Assorted Flavors
Mentos® Gum UP2U – Assorted Flavors

Nature’s Stance (XyliChew)
XyliChew Gum: Black Licorice, Cinnamon, Fruit, Peppermint, Spearmint

Nicorette®
Nicorette Stop Smoking Aid – Coated Gum: Cinnamon Surge, Fruit Chill, Mint

Nutraceutical
Zylicious™ Xylitol gum
XyliVita™ Gum

Orbit®
Orbit Gum – Assorted Flavors

Peelu
Cinnamon Sass Chewing Gum with Xylitol
Citrus Breeze Chewing Gum with Xylitol
Peppermint Blast Chewing Gum with Xylitol
Spearmint Chewing Gum with Xylitol

Peppersmith™
Chewing Gum – Assorted Flavors
Fresh Mints – Assorted Flavors

Pür
Pür Gum – Assorted Flavors
Pür Mints – Assorted Flavors

Rainbow Light®
MintAsure™

Rite Aid
Rite Aid Pharmacy Stop Smoking Aid – Sugar Free, Coated Gum: Cinnamon, Mint

Scandinavian Formulas
Salivasure™ Lozenges

Seroyal
Homeofresh Chewing Gum

Starbucks®
Gum
Mints

Stevita
SteviaDent™ Gum: Cinnamon, Peppermint

Stride Gum – Mondalez International
Stride Gum – NonStop Mint, Spark Kinetic Fruit, Spark Kinetic Mint, Spearmint

Supersmile®
Professional Whitening Gum

TheraBreath®
Professional Formula Sugar Free Chewing Gum
TheraBreath® Mouth-Wetting Lozenges
Zox Breath Mints

TheraMints™
100% Xylitol Lozenges

Trident® – Mondalez International
Trident Gum: Blueberry Twist®, Bubblegum, Cinnamon, Minty Sweet Twist, Original Flavor, Passionberry Twist®, Spearmint, Splashing Fruit™, Splashing Mint, Strawberry Twist, Tropical Twist®, Watermelon Twist®, Wintergreen

Walgreens
Walgreens Breath Strips Mint

Xlear®
SparX Candy: Berry, Citrus, Fruit
Spry Dental Defense Gum: Cinnamon, Fresh Fruit, Green Tea, Peppermint, Spearmint, Strawberry
Spry Gem Mints: Berry, Cinnamon, Lemon Creme, Peppermint, Spearmint
Spry Mints: BerryBlast, Cinnamon, Green Tea, Power Peppermint, Spearmint

Xylabrands
Xyla Ballpop Lollipops
Xyla Brand Xylitol Candy: Cherry, Citrus, Grape, Key Lime, Raspberry, Watermelon
Xyla Gum: Cinnamon, Fruit Punch, Peppermint, Spearmint,
Xyla Mints: Cocoa Mint, Fruit Punch, Lemon Lime, Licorice, Peppermint, Wintermint
Xyla Taffy: Assorted Flavors
Xyla Assorted 100% Natural Hard Candies

XyliChew
See Nature’s Stance above for product details

Zellie’s
Zellie’s Naturally Sugar Free Gum: Cinnamon, Fresh Fruit, Peppermint, Spearmint
Zellie’s Naturally Sugar Free Mints: Cool Fruit, Cool Mint, Cinnamon, Spearmint
Zellie’s Polar Bears: Cherry, Tropical Fruit

Zollipops®
Zollipops® Lollipops

Xylitol In Products: Honey, Raw Xylitol & Sweeteners

Xylitol product list sorted alphabetically by company or distributor

Designs For Health
Xylitol Powder 500 gms

Dr. John’s
Simply Xylitol Sweetener

Epic Dental
Xylitol Sweetener

Focus Nutrition
XyloBurst All-Natural Xylitol Sweetener Granuals
XyloBurst All-Natural Xylitol Sweetener Packets

Global Sweet
Smart Sweet Xylitol Granules
Smart Sweet Xylitol Honey

Hager Pharma
Hager Pharma Xylitol Sweetener

Health Garden
Real Birch Xylitol
Real Birch Xylitol Vanilla Sweetener

Jarrow Formulas Inc.
XyliPure Powder
Lo Han Sweet Powder

Life Enhancement
Sugar XE™ Sweetener

Nature’s Hollow
Sugar-Free Honey

NOW® Foods
Now Real Food – Xylitol
Now Real Food – Pure Xylitol Packets

NuNaturals
Sweet X™ Crystals

Nutraceutical
Kal® Xylitol Sweetener

Piping Rock
100%Pure Xylitol Natural Sweetener

Puritan’s Pride
Xylitol Powder

Source Naturals
XyliSmart® Sweetener

Swanson Health Products
Swanson Premium – 100% Pure Non-GMO Xylitol Granules
Swanson Premium – Xylitol Packets

Xlear®
Lite & Sweet
Xylo-Sweet

Xylabrands
Xyla Xylitol Packets
Xyla Xylitol Bulk
Xyla Powdered Xylitol

Zellie’s
Zellie’s Granular Xylitol
Zellie’s Pure Xylitol Packets

 Xylitol in Products: Dental & Nasal: Toothpaste, Floss, Mouthwash & Rinses

Xylitol product list sorted alphabetically by company or distributor

ACT®
Act Advanced Care™ Plaque Guard™ Mouthwash
Act Braces Care™ Mouthwash
Act Dry Mouth Lozenges
Act Dry Mouth Mouthwash
Act Dry Mouth Toothpaste
Act Total Care™ Sensitive Formula Mouthwash

American Biotech Labs
SilverSol Tooth Gel

Aquafresh® – GSK
Aquafresh Training Fluoride-Free Toothpaste

Auromere®
Ayurvedic Mouthwash

Babyganics®
Fluoride Free Toothpaste – Assorted Flavors

Biotene®
Dry Mouth Oral Rinse
Moisturizing Mouth Spray
Oral Balance Gel
PBF Oral Rinse

Branam™
All Natural Xylitol Tooth Gel – Assorted Flavors

Carifree®
CTx2 Spray
CTx3 Gel
CTx3 Rinse
CTx4 Gel 1100
CTx4 Treatment Rinse

Cleure™
Cleure Toothpaste – Assorted Flavors
Cleur Mouthwash – Assorted Flavors

Coral LLC
Coral Kids Toothpaste

Davids
Davids Premium Natural Toothpaste

Dentiste’
Dentiste’ Plus White Nighttime Toothpaste

doTERRA®
On Guard Toothpaste

Dr. Brown’s™
Nose & Face Wipes
Tooth & Gum Wipes

Dr. Collins
All White Toothpaste
Natural Toothpaste

Eco-Dent®
Res-Q-Dent Gel Toothpaste

Epic Dental
Fluoride & Xylitol Toothpaste
Spearmint Xylitol Mouthwash

Grants of Australia
Natural Toothpaste – Assorted Flavors
Natural Toothpaste Single Use Sachets
Xylitol Mint Natural Toothpaste
Xylitol Natural Mouthwash

H2Ocean®
H2Ocean Mouthwash – Assorted Flavors
Nasalzyme Maximum Strength Nasal Spray

Hager Pharma
Hager Pharma Dry Mouth Drops
Hager Pharma Happy Morning Xylitol Disposable Toothbrushes
Hager Pharma Xyli-Spray Sugar Free Fresh Breath Spray

Halo™
Halo Oral Antiseptic, Berry, Citrus

Healing Scents 
Tooth Gel – Assorted Flavors

Hello® 
Breath Spray – Assorted Flavors
Fluoride Toothpaste – Assorted Flavors
Kids Fluoride Toothpaste – Assorted Flavors
Mouthwash – Assorted Flavors

Heritage Store
Hydrogen Peroxide Tooth Powder
Hydrogen Peroxide Mouthwash + White
Hydrogen Peroxide Mouthwash Wintermint
Ipsab Tooth Powder, Cinnamon
Ipsab Whitening Toothpaste

IntelliWHiTE™
IntelliFRESH Breath Gel
IntelliFRESH Oral Rinse Fusion
IntelliWHiTE® CoolBlue Amplifier Gel Pen
IntelliWHiTE® Power Booster & Toothpaste Duo
PM Restore Night Serum
Power Boost Whitening Gel
PRO WhiTE Professional Toothpaste

Jack n’ Jill 
Natural Calendula Toothpaste – Assorted Flavors

Jason®
Healthy Mouth® Tartar Control Anti-Cavity Toothpaste
Healthy Mouth® Tartar Control Cinnamon Clove Mouthwash
Kids Only! Toothpaste – Assorted Flavors
Nutrismile® Enamel Defense Mouthwash
Nutrismile® Enamel Defense Anti-Cavity Toothpaste
Oral Comfort® Soothing Toothpaste
Powersmile® Moutwash: Brightening Peppermint, Strengthening Sea Spearmint, Super Refreshing Cinnamon Powermint
Powersmile® Whitening Anti-Cavity Toothpaste
Sea Fresh® Strengthening Anti-Cavity CoQ10 Gel Toothpaste

Kiss My Face
Obsessively Natural Kids™ Toothpaste – Berry Smart
Obsessively Natural Kids™ Fluoride Free Toothpaste – Berry Smart
Sensitive Fluoride Free Gel
Triple Action Fluoride Free Gel
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Triple Action Anticavity Fluoride Toothpaste
Whitening Gel – Anticavity Fluoride
Whitening Gel – Fluoride Free

Life Extension®
Florassist® Throat Health
Florassist® Oral Hygiene
Life Extension Toothpaste

Logona Naturkosmetik
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Melaleuca
Cool Shot® Breath Spray – Fresh Mint
Koala Pals® Tooth Gel – Assorted Flavors
Mouth Rinse – Assorted Flavors
Sensitive Tooth Polish
Whitening Tooth Polish – Assorted Flavors

MedActive®
Oral Relief Spray
Oral Relief Lozenges

Nature’s Answer 
PerioBrite® Natural Mouthwash – Assorted Flavors

Nature’s Gate
Toothpaste Gel – Cherry, Cool Mint, Wintergreen

NaturallyTaylored
Organic Toothpaste Remineralizing Toothpaste

NOW® Foods
Now Solutions – Activated Nasal Mist
Now Solutions – Xyliwhite™ Mouthwash: Cinnafresh, Neem & Tea Tree, Refreshmint
Now Solutions – Xyliwhite™ Toothpaste Gel: Bubblegum Splash, Cinnafresh, Orange Splash, Neem & Tea Tree, Refreshmint, Strawberry Splash
Now Solutions – Xyliwhite™ Plantinum Mint Toothpaste Gel w/ Baking Soda

Nuk – Gerber®
Grins & Giggles® Gum & Tooth Wipes

Nutraceutical
XyliVita™ Mouthwash
XyliVita™ Toothpaste – Assorted Flavors
XyliVita™ Sensitive Whitening Toothpaste – Cool Mint Chia

Oasis Dry Mouth
Oral Demulcent Moisturizing Spray

OraCoat / OraHealth
Avamin Melts – Healthy Mouth Lining
XyliMelts for Dry Mouth, Regular or Mint-Free
XyliGel with H-B12 for Dry Mouth and Mucositis

Organix South
TheraNeem Naturals – Neem Tooth & gum Powder
TheraNeem Naturals – Tea Tree Toothpaste

Parnell Pharmaceuticals
Mouth Kote Dry Mouth Spray

Peelu
Cinnamon Fluoride
Mint Free Fluoride
Peppermint Fluoride
Spearmint Fluoride

Radius
Cranberry Floss with Natural Xylitol
Vegan Xylitol Mint Floss

Redmond Trading Company
Earthpaste – Assorted Flavors

Seroyal
Homeofresh TP Anisum
Homeofresh TP Chlorophyllum
Homeofresh TP Citrus

Solay Wellness
Solay Smile Natural Tooth Powder – Assorted Flavors

Spiffies®
Lusterbrush Xylitol and Fluoride Tooth Gel
Spiffies Tooth Wipes – Assorted Flavors
Spiffies Tooth Gel – Assorted Flavors
Xyliclean Xylitol Oral Cleansing Solution

Squigle
Squigle Toothpaste
Tooth Builder Toothpaste

Starbrite
Whitening Toothpaste

Swanson Health Products
Swanson Ultra – Tea Tree Mouthwash Peppermint
Swanson Ultra – Whitening Toothpaste with Xylitol, Peelu and Tea Tree Oil
Swanson Ultra – Dry Mouth Relief

Tanner’s Tasty Paste®
Tasty Paste Toothpaste – Assorted Flavors

The Natural Dentist™
All in One Fluoride Toothpaste
Cavity Zapper Fluoride Rinse – Assorted Flavors
Fluoride-Free Toothpaste
Healthy Balance All-Purpose Rinse
Healthy Breath Antiseptic Rinse
Healthy Teeth Fluoride Rinse
Healthy White Pre-Brush Whitening Rinse
Whitening Fluoride Toothpaste

TheraBreath® 
Periotherapy Oral Rinse
Periotherapy Toothpaste
TheraBreath® Plus Oral Rinse
TheraBreath® Icy Mint Oral Rinse
TheraBreath® Soothing Oral Rinse
TheraBrite Plus® Toothpaste

Tom’s of Maine®
Antiplaque & Whitening Toothpaste – Fluoride-Free – Fennel, Peppermint, Spearmint
Antiplaque & Whitening Toothpaste Gel – Fluoride-Free – Spearmint
Cavity Protection Toothpaste – Peppermint Baking Soda, Spearmint
Children’s Anticavity Fluoride Rinse – Juicy Mint
Clean & Gentle Toothpaste – Peppermint
Enamel Strength® Toothpaste – Peppermint
Fluoride-Free Botanically Bright™ Toothpaste – Peppermint, Spearmint
Fluoride-Free Propolis Myrrh Toothpaste – Cinnamint, Fennel, Gingermint Baking Soda, Peppermint Baking Soda, Spearmint
Fluoride-Free Sensitive Toothpaste – Wintermint
Fluoride-Free Travel Natural Toothpaste – Fresh Mint
Maximum Strength Sensitive Toothpaste – Soothing Mint
Simply White Toothpaste – Clean Mint
Simply White Toothpaste Gel – Sweet Mint
Toddler Training Toothpaste – Mild Fruit
Travel Natural Toothpaste – Fresh Mint
Whole Care Toothpaste – Cinnamon Clove, Peppermint, Spearmint, Wintermint
Whole Care Toothpaste Gel – Peppermint
Wicked Fresh™ Mouthwash – Cool Mountain Mint, Peppermint Wave
Wicked Fresh™ Toothpaste – Spearmint Ice, Cool Peppermint

Walgreens®
Walgreens Dry Mouth Mouthwash

Vita-Myr
Children’s Toothpaste with Xylitol & Natural Orange Flavor
Zinc-Plus XTRA Toothpaste with Xylitol & Co Q 10

VMV Hypoallergenics
Essence Skin-Saving Toothpaste

Xlear®
Kid’s Xlear Saline Nasal Spray
Spry Bubble Gum Tooth Gel
Spry Floss with Xylitol
Spry Toothpaste- Cinnamon
Spry Toothpaste- Cinnamon Fluoride
Spry Coolmint Oral Rinse
Spry Spearmint Oral Rinse
Spry Whitening Kit
Spry Wintergreen Oral Rinse
Xlear Saline Nasal Spray with Xylitol
Xlear Sinus Care Rinse

Young Living™ 

Thieves® AromaBright™ Toothpaste
Thieves® Dentarome® Ultra Toothpaste
Thieves® KidScents® Slique™ Toothpaste

Xylitol In Products: Cosmetics & Hair Care

Xylitol product list sorted alphabetically by company or distributor

ApothecaryMuse
Chocolate Lavender Fields Forever Lip Balm

Aroma Naturals®
Therapeutic Lip Care – Assorted Flavors

Bain de Terre
Purité Healthy Color Protect Shampoo
Purité Healthy Moisture Repair Shampoo

Bioderma
Nodé Fluide Shampoo

Etude House
Dear My Jelly Lips-Talk
Sweet Recipe Candy Stick Lip Gloss – Assorted Colors

GlyMed Plus®
Cell Science Lip Science

Holistic Momma Organics
Mauve Melody Shimmer Lip Balm

Laura Mercier
Tinted Moisturizer – Illuminating Broad Spectrum SPF 20 Sunscreen

Lorac
Natural Performance Foundation

Missha
The Style Beautiful Lip Tint – Assorted Colors

NaturallyTaylored
Love Story Wedding Favor Lip Balm
Mason Jar Wedding Favor Lip Balm

True Natural
Natural Liquid Foundation – Assorted Colors

 Xylitol In Products: Final Thoughts

In the past 5 years, Pet Poison Helpline, an animal poison control based out of Minneapolis, MN, has had over 1500 calls for xylitol poisoning, due to the growing awareness of this common kitchen toxin.

If you suspect that your pet has eaten a xylitol-containing product, please contact your veterinarian or Pet Poison Helpline (800-213-6680) immediately.

Do not induce vomiting or give anything orally to your dog unless specifically directed to do so by your veterinarian. It is important to get treatment for your dog as quickly as possible.

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Chelsea Rivera
VP, Content & Media Relations
SimpleWag

OUR MISSION

SimpleWagTo promote all-natural methods to raise your pet in a healthy manner.

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Chelsea Rivera founded SimpleWag with one goal in mind: to help pet owners ensure their pets live the healthiest lives possible! SimpleWag offers its audience access to loads of great content, including expert information provided by staffed vets, trainers, and behavioral specialists. Additionally, SimpleWag offers a pet food alert that notifies you if your pet’s food has been recalled.There is so information out there that it can be overwhelming for well-intentioned pet owners but SimpleWag’s goal is to do the research so you don’t have to! In addition to working for SimpleWag, Chelsea spends her days getting bossed around by her 5 lb. Maltipoo, Baby Rose, in Los Angeles, CA.

Follow SimpleWag on Facebook or Instagram @simplewag.

Sreeni Labs Private Limited, Hyderabad, India ready to deliver New, Economical, Scalable Routes to your advanced intermediates & API’s in early Clinical Drug Development Stages


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Sreeni Labs Private Limited, Hyderabad, India is ready to take up challenging synthesis projects from your preclinical and clinical development and supply from few grams to multi-kilo quantities. Sreeni Labs has proven route scouting ability  to  design and develop innovative, cost effective, scalable routes by using readily available and inexpensive starting materials. The selected route will be further developed into a robust process and demonstrate on kilo gram scale and produce 100’s of kilos of in a relatively short time.

Accelerate your early development at competitive price by taking your route selection, process development and material supply challenges (gram scale to kilogram scale) to Sreeni Labs…………

INTRODUCTION

Sreeni Labs based in Hyderabad, India is working with various global customers and solving variety of challenging synthesis problems. Their customer base ranges from USA, Canada, India and Europe. Sreeni labs Managing Director, Dr. Sreenivasa Reddy Mundla has worked at Procter & Gamble Pharmaceuticals and Eli Lilly based in USA.

The main strength of Sreeni Labs is in the design, development of innovative and highly economical synthetic routes and development of a selected route into a robust process followed by production of quality product from 100 grams to 100s of kg scale. Sreeni Labs main motto is adding value in everything they do.

They have helped number of customers from virtual biotech, big pharma, specialty chemicals, catalog companies, and academic researchers and drug developers, solar energy researchers at universities and institutions by successfully developing highly economical and simple chemistry routes to number of products that were made either by very lengthy synthetic routes or  by using highly dangerous reagents and Suzuki coupling steps. They are able to supply materials from gram scale to multi kilo scale in a relatively short time by developing very short and efficient synthetic routes to a number of advanced intermediates, specialty chemicals, APIs and reference compounds. They also helped customers by drastically reducing number of steps, telescoping few steps into a single pot. For some projects, Sreeni Labs was able to develop simple chemistry and avoided use of palladium & expensive ligands. They always begin the project with end in the mind and design simple chemistry and also use readily available or easy to prepare starting materials in their design of synthetic routes

Over the years, Sreeni labs has successfully made a variety of products ranging from few mg to several kilogram scale. Sreeni labs has plenty of experience in making small select libraries of compounds, carbocyclic compounds like complex terpenoids, retinal derivatives, alkaloids, and heterocyclic compounds like multi substituted beta carbolines, pyridines, quinolines, quinolones, imidazoles, aminoimidazoles, quinoxalines, indoles, benzimidazoles, thiazoles, oxazoles, isoxazoles, carbazoles, benzothiazoles, azapines, benzazpines, natural and unnatural aminoacids, tetrapeptides, substituted oligomers of thiophenes and fused thiophenes, RAFT reagents, isocyanates, variety of ligands,  heteroaryl, biaryl, triaryl compounds, process impurities and metabolites.

Sreeni Labs is Looking for any potential opportunities where people need development of cost effective scalable routes followed by quick scale up to produce quality products in the pharmaceutical & specialty chemicals area. They can also take up custom synthesis and scale up of medchem analogues and building blocks.  They have flexible business model that will be in sink with customers. One can test their abilities & capabilities by giving couple of PO based (fee for service) projects.

Some of the compounds prepared by Sreeni labs;

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See presentation below

LINK ON SLIDESHARE

Sreeni Labs Profile from Sreenivasa Reddy

Managing Director at Sreeni Labs Private Limited\

 

Few Case Studies : Source SEEENI LABS

QUOTE………….

One virtual biotech company customer from USA, through a common friend approached Sreeni Labs and told that they are buying a tetrapeptide from Bachem on mg scale at a very high price and requested us to see if we can make 5g. We accepted the challenge and developed solution phase chemistry and delivered 6g and also the process procedures in 10 weeks time. The customer told that they are using same procedures with very minor modifications and produced the tetrapeptide ip to 100kg scale as the molecule is in Phase III.

 

One East coast customer in our first meeting told that they are working with 4 CROs of which two are in India and two are in China and politely asked why they should work with Sreeni Labs. We told that give us a project where your CROs failed to deliver and we will give a quote and work on it. You pay us only if we deliver and you satisfy with the data. They immediately gave us a project to make 1.5g and we delivered 2g product in 9 weeks. After receiving product and the data, the customer was extremely happy as their previous CRO couldn’t deliver even a milligram in four months with 3 FTEs.

 

One Midwest biotech company was struggling to remove palladium from final API as they were doing a Suzuki coupling with a very expensive aryl pinacol borane and bromo pyridine derivative with an expensive ligand and relatively large amount of palldium acetate. The cost of final step catalyst, ligand and the palladium scavenging resin were making the project not viable even though the product is generating excellent data in the clinic. At this point we signed an FTE agreement with them and in four months time, we were able to design and develop a non suzuki route based on acid base chemistry and made 15g of API and compared the analytical data and purity with the Suzuki route API. This solved all three problems and the customer was very pleased with the outcome.

 

One big pharma customer from east coast, wrote a structure of chemical intermediate on a paper napkin in our first meeting and asked us to see if we can make it. We told that we can make it and in less than 3 weeks time we made a gram sample and shared the analytical data. The customer was very pleased and asked us to make 500g. We delivered in 4 weeks and in the next three months we supplied 25kg of the same product.

 

Through a common friend reference, a European customer from a an academic institute, sent us an email requesting us to quote for 20mg of a compound with compound number mentioned in J. med. chem. paper. It is a polycyclic compound with four contiguous stereogenic centers.  We gave a quote and delivered 35 mg of product with full analytical data which was more pure than the published in literature. Later on we made 8g and 6g of the same product.

 

One West coast customer approached us through a common friend’s reference and told that they need to improve the chemistry of an advanced intermediate for their next campaign. At that time they are planning to make 15kg of that intermediate and purchased 50kg of starting raw material for $250,000. They also put five FTEs at a CRO  for 5 months to optimize the remaining 5 steps wherein they are using LAH, Sodium azide,  palladium catalyst and a column chromatography. We requested the customer not to purchase the 50kg raw material, and offered that we will make the 15kg for the price of raw material through a new route  in less than three months time. You pay us only after we deliver 15 kg material. The customer didn’t want to take a chance with their timeline as they didn’t work with us before but requested us to develop the chemistry. In 7 weeks time, we developed a very simple four step route for their advanced intermediate and made 50g. We used very inexpensive and readily available starting material. Our route gave three solid intermediates and completely eliminated chromatographic purifications.

 

One of my former colleague introduced an academic group in midwest and brought us a medchem project requiring synthesis of 65 challenging polyene compounds on 100mg scale. We designed synthetic routes and successfully prepared 60 compounds in a 15 month time.  

UNQUOTE…………

 

The man behind Seeni labs is Dr. Sreenivasa Reddy Mundla 

Sreenivasa Reddy

Dr. Sreenivasa Reddy Mundla.

Managing Director at Sreeni Labs Private Limited

Sreeni Labs Private Limited

Road No:12, Plot No:24,25,26

  • IDA, Nacharam
    Hyderabad, 500076
    Telangana State, India

Links

LINKEDIN https://in.linkedin.com/in/sreenivasa-reddy-10b5876

FACEBOOK https://www.facebook.com/sreenivasa.mundla

RESEARCHGATE https://www.researchgate.net/profile/Sreenivasa_Mundla/info

EMAIL mundlasr@hotmail.com,  Info@sreenilabs.com, Sreeni@sreenilabs.com

Dr. Sreenivasa  Reddy Mundla

Dr. M. Sreenivasa Reddy obtained Ph.D from University of Hyderabad under the direction Prof Professor Goverdhan Mehta in 1992. From 1992-1994, he was a post doctoral fellow at University of Wisconsin in Professor Jame Cook’s lab. From 1994 to 2000,  worked at Chemical process R&D at Procter & Gamble Pharmaceuticals (P&G). From 2001 to 2007 worked at Global Chemical Process R&D at Eli Lilly and Company in Indianapolis. 

In 2007  resigned to his  job and founded Sreeni Labs based in Hyderabad, Telangana, India  and started working with various global customers and solving various challenging synthesis problems. 
The main strength of Sreeni Labs is in the design, development of a novel chemical route and its development into a robust process followed by production of quality product from 100 grams to 100’s of kg scale.
 

They have helped number of customers by successfully developing highly economical simple chemistry routes to number of products that were made by Suzuki coupling. they are able to shorten the route by drastically reducing number of steps, avoiding use of palladium & expensive ligands. they always use readily available or easy to prepare starting materials in their design of synthetic routes.

Sreeni Labs is Looking for any potential opportunities where people need development of cost effective scalable routes followed by quick scale up to produce quality products in the pharmaceutical & specialty chemicals area. They have flexible business model that will be in sink with customers. One can test their abilities & capabilities by giving PO based projects

Experience

Founder & Managing Director

Sreeni Labs Private Limited

August 2007 – Present (8 years 11 months)

Sreeni Labs Profile

Sreeni Labs Profile

View On SlideShare

Principal Research Scientist

Eli Lilly and Company

March 2001 – August 2007 (6 years 6 months)

Senior Research Scientist

Procter & Gamble

July 1994 – February 2001 (6 years 8 months)

Education

University of Hyderabad

Doctor of Philosophy (Ph.D.), 
1986 – 1992

 

PUBLICATIONS

Article: Expansion of First-in-Class Drug Candidates That Sequester Toxic All-Trans-Retinal and Prevent Light-Induced Retinal Degeneration

Jianye Zhang · Zhiqian Dong · Sreenivasa Reddy Mundla · X Eric Hu · William Seibel ·Ruben Papoian · Krzysztof Palczewski · Marcin Golczak

Article: ChemInform Abstract: Regioselective Synthesis of 4Halo ortho-Dinitrobenzene Derivative

Sreenivasa Mundla

Aug 2010 · ChemInform

Article: Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Factor-β Receptor Type I Inhibitor as Antitumor Agent

Hong-yu Li · William T. McMillen · Charles R. Heap · Denis J. McCann · Lei Yan · Robert M. Campbell · Sreenivasa R. Mundla · Chi-Hsin R. King · Elizabeth A. Dierks · Bryan D. Anderson · Karen S. Britt · Karen L. Huss

Apr 2008 · Journal of Medicinal Chemistry

Article: ChemInform Abstract: A Concise Synthesis of Quinazolinone TGF-β RI Inhibitor Through One-Pot Three-Component Suzuki—Miyaura/Etherification and Imidate—Amide Rearrangement Reactions

Hong-yu Li · Yan Wang · William T. McMillen · Arindam Chatterjee · John E. Toth ·Sreenivasa R. Mundla · Matthew Voss · Robert D. Boyer · J. Scott Sawyer

Feb 2008 · ChemInform

Article: ChemInform Abstract: A Concise Synthesis of Quinazolinone TGF-β RI Inhibitor Through One-Pot Three-Component Suzuki—Miyaura/Etherification and Imidate—Amide Rearrangement Reactions

Hong-yu Li · Yan Wang · William T. McMillen · Arindam Chatterjee · John E. Toth ·Sreenivasa R. Mundla · Matthew Voss · Robert D. Boyer · J. Scott Sawyer

Nov 2007 · Tetrahedron

Article: Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

Hong-yu Li · Yan Wang · Charles R Heap · Chi-Hsin R King · Sreenivasa R Mundla · Matthew Voss · David K Clawson · Lei Yan · Robert M Campbell · Bryan D Anderson · Jill R Wagner ·Karen Britt · Ku X Lu · William T McMillen · Jonathan M Yingling

Apr 2006 · Journal of Medicinal Chemistry

Read full-textSource

Article: Studies on the Rh and Ir mediated tandem Pauson–Khand reaction. A new entry into the dicyclopenta[ a, d]cyclooctene ring system

Hui Cao · Sreenivasa R. Mundla · James M. Cook

Aug 2003 · Tetrahedron Letters

Article: ChemInform Abstract: A New Method for the Synthesis of 2,6-Dinitro and 2Halo6-nitrostyrenes

Sreenivasa R. Mundla

Nov 2000 · ChemInform

Article: ChemInform Abstract: A Novel Method for the Efficient Synthesis of 2-Arylamino-2-imidazolines

Read at

[LINK]

Patents by Inventor Dr.Sreenivasa Reddy Mundla

  • Patent number: 7872020

    Abstract: The present invention provides crystalline 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)-5,6-dihydro -4H-pyrrolo[1,2-b]pyrazole monohydrate.

    Type: Grant

    Filed: June 29, 2006

    Date of Patent: January 18, 2011

    Assignee: Eli Lilly and Company

    Inventor: Sreenivasa Reddy Mundla

  • Publication number: 20100120854

    Abstract: The present invention provides crystalline 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole monohydrate.

    Type: Application

    Filed: June 29, 2006

    Publication date: May 13, 2010

    Applicant: ELI LILLY AND COMPANY

    Inventor: Sreenivasa Reddy Mundla

  • Patent number: 6066740

    Abstract: The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by further reacting yields this isolated derivative with the appropriate amine or its salts in the presence of a proton source. The present process allows for the preparation of 2-amino-2-imidazolines, quanidines, and 2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that eliminate the need for lengthy, costly, or multiple low yielding steps, and highly toxic reactants. This process allows for improved yields and product purity and provides additional synthetic flexibility.

    Type: Grant

    Filed: November 25, 1997

    Date of Patent: May 23, 2000

    Assignee: The Procter & Gamble Company

    Inventors: Michael Selden Godlewski, Sean Rees Klopfenstein, Sreenivasa Reddy Mundla, William Lee Seibel, Randy Stuart Muth

TGF-β inhibitors

US 7872020 B2

Sreenivasa Reddy Mundla

The present invention provides 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl) -5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole monohydrate, i.e., Formula I.

Figure US07872020-20110118-C00002

EXAMPLE 1 Preparation of 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl-5,6-dihydro-4H -pyrrolo[1,2-b]pyrazole monohydrate

Figure US07872020-20110118-C00008

Galunisertib

1H NMR (CDCl3): δ=9.0 ppm (d, 4.4 Hz, 1H); 8.23-8.19 ppm (m, 2H); 8.315 ppm (dd, 1.9 Hz, 8.9 Hz, 1H); 7.455 ppm (d, 4.4 Hz, 1H); 7.364 ppm (t, 7.7 Hz, 1H); 7.086 ppm (d, 8.0 Hz, 1H); 6.969 ppm (d, 7.7 Hz, 1H); 6.022 ppm (m, 1H); 5.497 ppm (m, 1H); 4.419 ppm (t, 7.3 Hz, 2H); 2.999 ppm (m, 2H); 2.770 ppm (p, 7.2 Hz, 7.4 Hz, 2H); 2.306 ppm (s, 3H); 1.817 ppm (m, 2H). MS ES+: 370.2; Exact: 369.16

ABOVE MOLECULE IS

https://newdrugapprovals.org/2016/05/04/galunisertib/

Galunisertib

Phase III

LY-2157299

CAS No.700874-72-2

 

 

READ MY PRESENTATION ON

Accelerating Generic Approvals, see how you can accelerate your drug development programme

Accelerating Generic Approvals by Dr Anthony Crasto

KEYWORDS   Sreenivasa Mundla Reddy, Managing Director, Sreeni Labs Private Limited, Hyderabad, Telangana, India,  new, economical, scalable routes, early clinical drug development stages, Custom synthesis, custom manufacturing, drug discovery, PHASE 1, PHASE 2, PHASE 3,  API, drugs, medicines

Kiran Mazumdar Shaw Conferred with ‘The Global Leadership in Engineering 2016’ Award by USC


KMS-ON-USC-VITERBI-AWARD.png.

 

http://societyofwomenengineers.swe.org/awards/individual-awards/4153-global-leadership

Society of Women Engineers

The Global Leadership Award honors a person with at least fifteen (15) years professional experience who has worked in and led an internationally based engineering, scientific or technology-based business or organization, and in doing so, serves as a role model to women engineers and technologists worldwide. A maximum of three (3) awards may be presented annually.

 

 

Biocon

“This award is a recognition of Biocon’s significant role in harnessing the potential of Biotechnology to provide affordable access to highly complex bio-pharmaceuticals like Insulins and monoclonal antibodies for the benefit of patients the world over.” – Kiran Mazumdar-Shaw

Kiran Mazumdar-Shaw

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

//////Kiran Mazumdar Shaw,  ‘The Global Leadership in Engineering 2016’ , Award by USC

I (Anthony Crasto) am Editorial Board member for our Journal of Analytical & Pharmaceutical Research


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Dear Readers
I am on  editorial board ……… Editorial Board member for our Journal of Analytical & Pharmaceutical Research………http://medcraveonline.com/JAPLR/editorial-board

This is possible with your cooperation and support

SOME PAPERS

read…….http://medcraveonline.com/JAPLR/JAPLR-02-00010.pdf
http://medcraveonline.com/JAPLR/JAPLR-02-00011.pdf

Tackling the Challenges with Poorly Soluble Drugs
http://medcraveonline.com/JAPLR/JAPLR-01-00001.pdf

New Drug Approvals Blog has 2 lakh plus viewers in USA alone


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New Drug Approvals Blog has 2 lakh plus viewers in USA alone

that is 200 thousand viewers

A record 1170135 views (11 lakh plus)all over the world in 211 countries

that is 1100 thousand plus views on this blog

I suffered a paralytic stroke in dec 2007 and bound to a wheelchair, this seems to have injected feul in me to help chemists around the world, I am more active than before and  pushing boundaries, I have 2,5 lakh connections on all networking sites, I am available to all, contact me on +91 9323115463, amcrasto@gmail.com, Twitter @amcrasto

 

 

 

My son lionel was only in first standard in school when I was hit by a deadly one in a million spine stroke called acute transverse mylitis, it made me 90% paralysed and bound to a wheel chair, He cried bitterly and we had never seen him so depressed

Now I keep Lionel as my source of inspiration and helping millions, thanks to millions of my readers who keep me going and help me to keep my son and family happy.

success

 

////////////

Zydus Cadila’s, Lipaglyn (Saroglitazar) won a lot of support at the 75th Anniversary Conference of the American Diabetes Association


Lipaglyn (Saroglitazar) won a lot of support at the 75th Anniversary Conference of the American Diabetes Association. Lipaglyn is currently under Phase III clinical development for treatment of Non Alcoholic SteatoHepatitis (NASH), a serious liver disease and an unmet healthcare need, globally. There is currently no drug approved for treating NASH. Lipaglyn is already approved in India for the treatment of diabetic dyslipidemia

Zydus Group

20160215_115547.jpg

Speaking on the development, Mr. Pankaj R. Patel, Chairman and Managing Director, Zydus Cadila said, “These new robust scientific data on the safety and efficacy of Lipaglyn
(Saroglitazar) being presented at the 75th Annual Scientific Sessions of the American Diabetes Association (ADA) reflect our continued commitment to millions of patients living with Diabetes, Dyslipidemia, Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic steatohepatitis (NASH).”

Zydus Cadila, a leading global healthcare provider, today announced that new scientific and clinical data on Saroglitazar will be presented at the 75th Annual Scientific Sessions of the American Diabetes Association (ADA) in Boston, Massachusetts, USA from 5thto 9th June, 2015. Several analyses of real-world patient data of Saroglitazar will also be presented. The abstracts are available on theADA website.

Lipaglyn – The world’s first drug for treating Diabetic Dyslipidemia combines lipid and glucose lowering effects in one single molecule.

Pankaj Patel, chairman and MD, Cadila Healthcare Ltd

 

 

 

Zydus is an innovation-led global healthcare provider that discovers, manufactures and markets a broad range of healthcare therapies. The group employs over 19,000 people worldwide including over 1200 scientists engaged in research and is dedicated to creating healthier communities globally.

With a strong research pipeline of NCEs, biologics and vaccines, the group became India’s first pharmaceutical company to launch its own indigenously researched therapy Lipaglyn which is also the world’s first approved therapy for diabetic dyslipidaemia. Exemptia, the world’s first biosimilar of Adalimumab is also a product of Zydus innovation. Zydus also collaborates with partners to support and make therapies affordable and accessible to communities across the world.

As a leading healthcare provider, it aims to become a global research-based pharmaceutical company by 2020.

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Zydus Group

 

Pankaj R. Patel (left), Chairman & Managing Director, Zybus Cadila,

Ganesh Nayak, Chief Operating Officer and Executive Director, Zydus Cadila

 

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Zydus Cadila has announced a breakthrough in the anti-diabetic drug Lipaglyn. Lipaglyn – The world’s first drug for treating Diabetic Dyslipidemia combines lipid and glucose lowering effects in one single molecule.

The Zydus Group announced a breakthrough in its research efforts with Lipaglyn (Saroglilazar), a novel drug targeted at bridging an unmet healthcare need for treating Diabetic Dyslipidemia or Hypertriglyeeridemia in Type II diabetes, not controlled by statins alone. The drug has been approved for launch in India by the Drug Controller General of India (DCGI). With a novel action that offers lipid and glucose lowering effects in one molecule, Lipaglyn is the first Glitazar to be approved anywhere in the world.
“Lipaglyn provides patients suffering from diabetic dyslipidemia the option of a once-daily oral therapy that has a beneficial effect on both lipid parameters as well as glycemic control,” said Pankaj R. Fatel, Chairman and Managing Director, Zydus Cadila. “It has always been our dream to take a molecule right from the concept stage up to its launch. Today, we have realized this dream. It is an important breakthrough and I would like to dedicate this to all the Indian research scientists in the Held of drug discovery,” Patel added,
Diabetic Dyslipidemia is a condition where a person is diabetic and has elevated levels of the total cholesterol, the “bad” low-density lipoprotein (LDL) cholesterol and the triglycerides and a decrease in the “good” high-density lipoprotein (HDL) cholesterol concentration in the blood. Optimal LDL cholesterol levels ibr adults with diabetes are less than 100 mg/dh, optimal HDL cholesterol levels are equal to or greater than 40 mg/dL, and desirable triglycerides levels are less than 150 mg/dLT LipaglynrM, a non-thiazoKdinedione, is the first therapy to be approved for this condition,
World over, it is estimated that 30% of all deaths occur due lo cardiovascular diseases (CVD). In India, one out of every five persons is at serious risk of developing CVD, Research has shown that diabetes is one of the major risk factors of CVD. India has a population of nearly 65 million diabetics and 77 million prc-diabctics, 85 – 97% of the diabetes patients suffer from dyslipidemia or lipid abnormalities. Hence, addressing the problem of diabetes and dyslipidemia is crucial in tackling the health risk posed by CVD.
Discovered by the Zydus Research Centre, the dedicated NCE research arm of the Zydus group, LipaglynrM is a best-in-class innovation, designed to have a unique cellular mechanism of action following an extensive structure-activity relationship study initiated in the year 2000, Lipaglyn1M has a predominant affinity to PPAR alpha isoform and moderate affinity to PPAR gamma isoform of PPAR nuclear receptor subfamily. The molecule has shown beneficial effects on lipids and glyeemic control without side effects. This molecule underwent extensive pre-clinical characterisation and the I.ND was submitted in the year 2004,
As a part of the clinical development programme, extensive Phase-I, Phase-II and Phase-Ill clinical trials were conducted to evaluate the phamacokinetics, pharmacodynamics, efficacy and safety of Lipaglyn. The new drug application for Lipaglyn1 was based on a comprehensive clinical development programme spanning eight years.
Results from the first Phase III programme with Pioglitazone as a comparator drug in diabetes patients showed that the 4 mg dose of Lipaglyn led to a reduction of triglycerides and LDL (bad) cholesterol, and an increase in HDL (good) cholesterol and also showed a reduction in Fasting Plasma Glucose and glycosylated haemoglobin (HbAlc) thereby confirming its beneficial effects of both lipid and glyeemic control in diabetic patients,
In the second Phase III study, Lipaglyn was studied in diabetic dyslipidemic patients insufficiently controlled with statin therapy. The results from this study confirmed that Lipaglyn had a pronounced beneficial effect on both the lipid and glyeemic parameters in these subjects.
In both the studies, Lipaglyn was well tolerated and had a better safety profile than the comparators. Importantly Lipaglyn1 M has a non-renal route of elimination, and did not show adverse events like edema, weight gain, myopathies or derangement of liver and/or kidney functions, thus making it sale and efficacious. LipaglynIM is recommended for once daily administration as 4 mg tablets.
Zydus will offer a dedicated LipaglynIM support programme to patients and earegivers, The programme shall provide important support and information regarding access, adherence, education and thereby help patients to start and appropriately manage their disease and therapy over time.

About Lipaglyn

Lipaglyn[TM] (Saroglitazar) was launched in September 2013 in India, for treating Hypertriglyceridemia and Diabetic Dyslipidemia in Patients with Type 2 Diabetes not controlled by statins. Since then, more than 80,000 patients are availing this drug with a prescriber base over 3500 diabetologists, cardiologists and physicians. Lipaglyn[TM] helps in a reduction of triglycerides and LDL (bad) cholesterol, and an increase in HDL (good) cholesterol and has also shown a reduction in Fasting Plasma Glucose and glycosylated haemoglobin (HbA1c), thereby confirming its beneficial effects on both lipid and glycemic control in diabetic patients. Lipaglyn[TM] is a prescription medicine, and can be taken only under the advice and guidance of a registered medical practitioner.

About Zydus

Zydus Cadila is an innovative, global pharmaceutical company that discovers, manufactures and markets a broad range of healthcare therapies, including small molecule drugs, biologic therapeutics and vaccines. The group employs over 16,500 people worldwide including over 1200 scientists engaged in R & D and is dedicated to creating healthier communities globally. As a leading healthcare provider, it aims to become a global research based pharmaceutical company by 2020.

References

Zydus to present new scientific data on Lipaglyn in the US

New Delhi, Jun 8 (UNI) Healthcare services provider, Zydus Cadila today said the new scientific and clinical data on Lipaglyn (Saroglitazar) will be presented at the 75th annual scientific sessions of the American Diabetes Association (ADA) in Boston, Massachusetts, US from 5th to 9th June,2015.
Read more at http://www.uniindia.com/news/business-economy/zydus-to-present-new-scientific-data-on-lipaglyn-in-the-us/84440.html

READ …..https://newdrugapprovals.org/2013/06/07/cadila-banks-on-diabetes-druglipaglynsaroglitazar/

SEE…..https://newdrugapprovals.org/2015/03/09/saroglitazar-magnesium-new-patent-wo-2015029066-cadila-healthcare-ltd/

http://lipaglyn.com/downloads/Lipaglyn_Product_Monograph.pdf

http://www.ijpcs.net/sites/default/files/IJPCS_3_1_02_0.pdf

http://zyduscadila.com/wp-content/uploads/2015/08/Saroglitazar-in-Diabetic-Dyslipidemia-1-Year-Data.pdf

http://onlinelibrary.wiley.com/doi/10.1002/prp2.136/pdf

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Mr. Glenn Saldanha Chairman & and Managing Director, Glenmark Pharmaceuticals Limited, conferred ‘India Pharma Leader Award’ by the Government of India


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Mr. Glenn Saldanha Chairman & and Managing Director, Glenmark Pharmaceuticals Limited, conferred ‘India Pharma Leader Award’ by the Government of India

Indian Ministry for Chemicals and Fertilizers on Thursday conferred 1st India Pharma awards to 12 Indian drug companies under various categories to motivate Indian Pharma and medical devices industries.

As per reports, Union Minister for Chemicals and Fertilizers Ananth Kumar conferred 1st India Pharma awards in Bengaluru on Thursday evening.

Speaking on the occasion, Ananth Kumar said that the Pharma Industry in the country is growing at a higher rate than GDP and needs to be complimented for this.
“Indian government would like domestic Pharma industry to be global leaders,” he said, adding that the government and the Pharma entrepreneurs will work together as team Pharma India, with the aim of serving millions of ailing people. He also assured full support to the industry.

The awards constituted by Department of Pharmaceuticals were given to outstanding Pharma Industries to motivate Indian Pharma and medical devices industries. The winner of the awards are:

CATEGORY OF AWARD NAME OF THE COMPANY
OVERALL INDIA PHARMA EXCELLENCE AWARD CADILA HEALTHCARE LIMITED

INDIA PHARMA LEADER AWARD GLENN SALDANA, CHAIRMAN & MANAGING DIRECTOR, GLENMARK PHARMACEUTICALS LIMITED

INDIA PHARMA COMPANY OF THE YEAR AWARD LUPIN LIMITED

INDIA PHARMA BULK DRUG COMPANY OF THE YEAR AWARD SMS PHARMACEUTICALS LTD

INDIA PHARMA INNOVATION OF THE YEAR AWARD CADILA HEATHCARE LIMITED

INDIA PHARMA RESEARCH AND DEVELOPMENT ACHIEVEMENT AWARD SUN PHARMACEUTICALS INDUSTRIES LTD

INDIA PHARMA CORPORATE SOCIAL RESPONSIBILITY PROGRAMME OF THE YEAR AWARD ABBOTT INDIA LIMTED

INDIA PHARMA MEDICAL DEVICES COMPANY OF THE YEAR AWARD HARSORIA HEALTHCARE PVT LTD

INDIA PHARMA EXPORT COMPANY OF THE YEAR AWARD CAMUS PHARMA PVT LTD

INDIA PHARMA BULK DRUG EXPORT COMPANY OF THE YEAR SMS PHARMACEUTICALS LTD

INDIA PHARMA MEDICAL DEVICES EXPORT COMPANY OF THE YEAR AWARD SCOPE MEDICAL DEVICES PVT LTD

SPECIAL AWARD: PHARMA PSU COMPANY OF THE YEAR AWARD KARNATAKA ANTIBIOTICS AND PHARMACEUTICALS LIMITED, A PSU UNDER DEPARTMENT OF PHARMACEUTICALS

CLIP

India Pharma Awards given by Minister of Chemicals and …

pib.nic.in/newsite/PrintRelease.aspx?relid=134291

Jan 8, 2016 – OVERALL INDIA PHARMA EXCELLENCE AWARD. CADILA HEALTHCARE LIMITED. INDIA PHARMA LEADER AWARD. SHRI GLENN …

Press Information Bureau
Government of India
Ministry of Chemicals and Fertilizers
08-January-2016 12:49 IST

India Pharma Awards given by Minister of Chemicals and Fertilizers

The Union Minister for Chemicals and Fertilizers, Shri Ananth Kumar gave away the 1st India Pharma awards in Bengaluru on Thursday evening. The awards constituted by Department of Pharmaceuticals were given to outstanding Pharma Industries to motivate Indian Pharma and medical devices industries. The winner of the awards are:

CATEGORY OF AWARD NAME OF THE COMPANY
OVERALL INDIA PHARMA EXCELLENCE AWARD CADILA HEALTHCARE LIMITED
INDIA PHARMA LEADER AWARD SHRI GLENN SALDANA, CHAIRMAN & MANAGING DIRECTOR, GLENMARK PHARMACEUTICALS LIMITED
INDIA PHARMA COMPANY OF THE YEAR AWARD LUPIN LIMITED
INDIA PHARMA BULK DRUG COMPANY OF THE YEAR AWARD SMS PHARMACEUTICALS LTD
INDIA PHARMA INNOVATION OF THE YEAR AWARD CADILA HEATHCARE LIMITED
INDIA PHARMA RESEARCH AND DEVELOPMENT ACHIEVEMENT AWARD SUN PHARMACEUTICALS INDUSTRIES LTD
INDIA PHARMA CORPORATE SOCIAL RESPONSIBILITY PROGRAMME OF THE YEAR AWARD ABBOTT INDIA LIMTED
INDIA PHARMA MEDICAL DEVICES COMPANY OF THE YEAR AWARD HARSORIA HEALTHCARE PVT LTD
INDIA PHARMA EXPORT COMPANY OF THE YEAR AWARD CAMUS PHARMA PVT LTD
INDIA PHARMA BULK DRUG EXPORT COMPANY OF THE YEAR SMS PHARMACEUTICALS LTD
INDIA PHARMA MEDICAL DEVICES EXPORT COMPANY OF THE YEAR AWARD SCOPE MEDICAL DEVICES PVT LTD
SPECIAL AWARD: PHARMA PSU COMPANY OF THE YEAR AWARD KARNATAKA ANTIBIOTICS AND PHARMACEUTICALS LIMITED, A PSU UNDER DEPARTMENT OF PHARMACEUTICALS

Speaking on the occasion the Shri Ananth Kumar said that the Pharma Industry in the country is growing at a higher rate than GDP and needs to be complimented for this.  He said that the government would like domestic Pharma industry to be global leaders. He said that the government and the Pharma entrepreneurs will work together as team Pharma India, with the aim of serving millions of ailing people.  Shri Ananth Kumar assured full support to the industry.

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References

http://www.pharmaceuticals.gov.in/sites/default/files/First%20India%20Pharma%20Awards%202015.pdf

http://pib.nic.in/newsite/PrintRelease.aspx?relid=134291

http://www.glenmarkpharma.com/common/pdf/Glenn_Saldanha-Profile.pdf

http://pharmaceuticals.gov.in/sites/default/files/First%20India%20Pharma%20Awards%202015%20%20Final.pdf

http://www.pharmaceuticals.gov.in/sites/default/files/First%20India%20Pharma%20Awards%202015.pdf

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Breaking and Making of Olefins Simultaneously Using Ozonolysis: Application to the Synthesis of Useful Building Blocks and Macrocyclic Core of Solomonamides


Abstract Image

A simple and practical one-pot, two-directional approach to access olefinic esters through simultaneous breaking and making of olefins using ozonolysis of alkenyl aryl selenides is disclosed. The scope of the method with a variety of examples is demonstrated, and the end products obtained here are useful building blocks. As a direct application of the present method, the macrocyclic core of potent anti-inflammatory natural cyclic peptides, solomonamides, is synthesized.

Breaking and Making of Olefins Simultaneously Using Ozonolysis: Application to the Synthesis of Useful Building Blocks and Macrocyclic Core of Solomonamides

CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. Homi Bhabha Road, Pune 411008, India
Org. Lett., 2015, 17 (9), pp 2090–2093
DOI: 10.1021/acs.orglett.5b00637
Publication Date (Web): April 14, 2015
Copyright © 2015 American Chemical Society
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GENERAL METHOD
 

Dr. D. Srinivasa Reddy

New Drug Approvals blog by Dr Anthony Crasto hits ten lakh views in 211 countries


 

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New Drug Approvals hits ten lakh views in 211 countries

https://newdrugapprovals.org/

 

 

 

 

ANTHONY MELVIN CRASTO

THANKS AND REGARD’S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
web link
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Dr. Anthony Melvin Crasto
Principal Scientist, Glenmark Pharma
    

 

 

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