DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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NEVIRAPINE
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Nevirapine (NVP), also marketed under the trade name Viramune (Boehringer Ingelheim), is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
As with other antiretroviral drugs, HIV rapidly develops resistance if nevirapine is used alone, so recommended therapy consists of combinations of three or more antiretrovirals.
Nevirapine was discovered by Hargrave et al. at Boehringer Ingelheim Pharmaceuticals, Inc., one of the Boehringer Ingelheim group of companies. It is covered by U.S. Patent 5,366,972 and corresponding foreign patents. Nevirapine was the first NNRTI approved by the U.S. Food and Drug Administration (FDA). It was approved June 21, 1996 for adults and September 11, 1998 for children. It was also approved in Europe in 1997.
Inspired by genericsweb
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Nevirapine, anti-AIDS drugs, 1996 FDA clearance to market under the trade name Viramune (Boehringer Ingelheim)
Nevirapine has the [6,7,6] tricyclic structure, in which A and C ring is the starting material is introduced and finally with two equivalents of NaH double anion formed in pyridine, and then ring closure reaction by SnAr (JMC, 1991, 2231 ).
New Drug Approvals 
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