

Elsovaptan
CAS 2296801-25-5
MFC19H20ClN5O2 MW385.8 g/mol
[(3S)-7-chloro-3-methyl-2,3-dihydro-1,4-benzoxazin-4-yl]-(6-pyrimidin-2-yl-2,6-diazaspiro[3.3]heptan-2-yl)methanone
[(3S)-7-chloro-3-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl][6-(pyrimidin-2-yl)-2,6-diazaspiro[3.3]heptan-2-yl]methanone
vasopressin receptor antagonist, Alzheimer disease, T206306, Y2Z74WGU3J
Elsovaptan is a selective vasopressin receptor antagonist. It is primarily used in scientific research to study the modulation of vasopressin action, particularly in the context of neurodegenerative conditions like Alzheimer’s disease
- Primary Mechanism: Blocks the binding of vasopressin to its receptors, which typically disrupts fluid volume regulation and can lead to vasodilation.
Research Applications
Currently, Elsovaptan is designated as a research-use-only compound and is not approved for human therapeutic or veterinary use.
Its study is often linked to research on:
- Neurodegenerative Diseases: Investigating the role of the vasopressin system in the progression of Alzheimer’s disease.
- Fluid Regulation: Understanding how antagonizing vasopressin affects vascular resistance and blood pressure.
The compound has been listed in recent International Nonproprietary Names (INN) proposals by the World Health Organization (WHO) for pharmaceutical substances, indicating it is an active subject of pharmacological study
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