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Dimeric Thymosin beta-4……..accelerates the rate of wound healing

October 3, 2013 3:45 am


Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains

http://www.dovepress.com/a-novel-dimeric-thymosin-beta-4-with-enhanced-activities-accelerates-t-peer-reviewed-article-DDDT

Thymosin beta 4 (Tβ4) is a peptide with 43 amino acids that is critical for repair and remodeling tissues on the skin, eye, heart, and neural system following injury

Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene.

The protein consists (in humans) of 43 amino acids (msdkpdmaei ekfdksklkk tetqeknplp sketieqekq ages) molWt 4921

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NMR structure of a β-thymosin. Both thymosin α1  and β-thymosins areintrinsically unstructured proteins, i.e. they lack a stable fold when free in aqueous solution. This structure, mostly alpha helix, was artificially stabilised by an organic solvent. The thymosin illustrated, originally named β9 is the cow orthologue of human β10

Beta thymosins are a family of proteins which have in common a sequence of about 40 amino acids similar to the small protein thymosin β4. They are found almost exclusively in multicellular animals. Thymosin β4 was originally obtained from the thymus in company with several other small proteins which although named collectively “thymosins” are now known to be structurally and genetically unrelated and present in many different animal tissues.

It has been studied in a number of clinical trials.

The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiacprogenitor cells to repair damaged heart tissue.

Doping in Sports

Thymosin beta-4 was allegedly used by some players in various Australian football codes and is under investigation by the Australian Sports Anti-Doping Authority for anti-doping violations (Feb/Mar 2013):

https://theconversation.edu.au/cronulla-sharks-and-thymosin-beta-4-is-it-doping-12694

 

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Posted by DR ANTHONY MELVIN CRASTO Ph.D

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4 Responses to “Dimeric Thymosin beta-4……..accelerates the rate of wound healing”

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