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Debiopharm and Aurigene dual c-src / jak inhibitors

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STR3str4

Debio 1142

Jak2 tyrosine kinase inhibitor; Src tyrosine kinase inhibitor

N-[4-methyl-3-[2-[4-(4-methylpiperazin-1-yl)anilino]-5-oxo-7,8-dihydropyrido[4,3-d]pyrimidin-6-yl]phenyl]-3-(trifluoromethyl)benzamide

Molecular Formula: C33H32F3N7O2
Molecular Weight: 615.64809 g/mol
1332328-01-4
Benzamide, N-​[3-​[7,​8-​dihydro-​2-​[[4-​(4-​methyl-​1-​piperazinyl)​phenyl]​amino]​-​5-​oxopyrido[4,​3-​d]​pyrimidin-​6(5H)​-​yl]​-​4-​methylphenyl]​-​3-​(trifluoromethyl)​-

Debiopharm S.A., Aurigene Discovery Technologies Ltd.

ALLISTER Andrès MC, Maximilien Murone,Saumitra Sengupta, Shankar Jayaram Shetty

https://www.google.co.in/patents/WO2011101806A1?cl=en

Bicyclic compounds and their uses as dual c-src / jak inhibitors

STR3

Apr. 14 /PR Newswire/ –Debiopharm and Aurigene Sign Agreement for the Development and Commercialisation of Debio 1142, a Novel Inhibitor of an Undisclosed Oncology Pathway

LAUSANNE, Switzerland and BANGALORE, India, April 14, 2011 /PRNewswire/ — Debiopharm Group(TM) (Debiopharm), a global biopharmaceutical development specialist that focuses on serious medical conditions and particularly oncology, and Aurigene Discovery Technologies Ltd (Aurigene), a Bangalore-based drug discovery company, signed on March 23, 2011 an option and exclusive worldwide license agreement concerning the development and commercialisation of Debio 1142, a novel inhibitor of an undisclosed oncology pathway.

“We are very excited about this new collaboration with Aurigene. Their business model offers a one stop solution for structure guided drug design, lead optimisation and preclinical work. The Debio 1142 project aims at developing inhibitors targeting a key oncology pathway, which plays essential roles in various solid tumours, including resistance to chemotherapy” said Dr Rolland-Yves Mauvernay, president and founder of Debiopharm S.A.

“Coming as it does after a successful collaboration programme we already had with Debiopharm, and as a continuation of our close to 5 year association, the relationship between Debiopharm and Aurigene demonstrates the strategic fit between organisations with complimentary scientific skills. We are happy that we have the opportunity to continue to work with Debiopharm, in a unique business model that has been tailor-made to meet each partners’ needs” added CSN Murthy, CEO of Aurigene.

About Debiopharm Group

Debiopharm Group(TM) (Debiopharm) is a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs. The group in-licenses, develops and/or co-develops promising biological and small molecule drug candidates having reached clinical development phases I, II or III as well as earlier stage candidates. It develops its products for global registration and maximum commercial potential. The products are out-licensed to pharmaceutical partners for sales and marketing. Debiopharm Group is also active in the field of companion diagnostics with a view to progressing in the area of personalised medicine. Debiopharm independently funds the worldwide development of all of its products while providing expertise in pre-clinical and clinical trials, manufacturing, drug delivery and formulation, and regulatory affairs. For more information on Debiopharm Group(TM), please visit: http://www.debiopharm.com.

About Aurigene

Aurigene Discovery Technologies Limited is a Bangalore-based biotech focused on collaborative drug discovery with pharmaceutical and biotech companies on a risk-sharing basis. Aurigene has fully integrated drug discovery infrastructure, from Target to IND, along with strong in house structural biology and fragment based drug design capabilities. The company is engaged in over 20 discovery collaborations with US and European large and mid-pharma companies in Oncology, Inflammatory disorders and anti-infectives. For more information on Aurigene, please visit: http://www.aurigene.com.

PATENT

WO 2011101806

http://www.google.co.in/patents/WO2011101806A1?cl=en

PAPER

Journal of Chemical and Pharmaceutical Research (2014), 6(4), 1146-1152

http://jocpr.com/vol6-iss4-2014/JCPR-2014-6-4-1146-1152.pdf

REFERENCES

INDIAN PATENTS

7554/CHENP/2012

415/CHE/2010

https://www.debiopharm.com/our-business/pipeline.html

http://www.giiresearch.com/report/labd315710-debiopharm-international-sa-product-pipeline.html

Patent ID Date Patent Title
US2013143895 2013-06-06 BICYCLIC COMPOUNDS AND THEIR USES AS DUAL C-SRC / JAK INHIBITORS
US8440679 2013-05-14 Bicyclic compounds and their uses as dual c-SRC / JAK inhibitors

///////////Debio 1142, Jak2 tyrosine kinase inhibitor,  Src tyrosine kinase inhibitor, Debio-1142, Debiopharm S.A.Aurigene Discovery Technologies Ltd, 1332328-01-4

c21cnc(nc1CCN(C2=O)c3c(ccc(c3)NC(=O)c4cc(ccc4)C(F)(F)F)C)Nc5ccc(cc5)N6CCN(CC6)C


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DR ANTHONY CRASTO

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 29 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 29 year tenure till date Aug 2016, Around 30 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 25 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 13 lakh plus views on New Drug Approvals Blog in 212 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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