DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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![N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide](https://i2.wp.com/pic3.molbase.net/molpic/02/47/2473420.png)
| N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide | |
| CAS No.: | 739366-20-2 |
|---|---|
| Synonyms: |
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| Formula: | C19H25N7O2 |
| Exact Mass: | 383.20700 |
Anagliptin chemically known as N-[2-[2-[2(S)-cyanopyrrolidin-l-yl]-2-oxoethylamino]- 2-methylpropyl]-2-methylpyrazolo[l,5-a]pyrimidine-6-carboxamide is represented by the structural formula:
Anagliptin is a dipeptidyl peptidase IV- inhibitor. United States Patent No 7345 1 80- (IJS’ 180) discloses anagliptin.
![N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide NMR spectra analysis, Chemical CAS NO. 739366-20-2 NMR spectral analysis, N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide H-NMR spectrum](https://i2.wp.com/pic11.molbase.net/nmr/nmr_image/2014-11-28/002/473/2473420_1h.png)
![N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide NMR spectra analysis, Chemical CAS NO. 739366-20-2 NMR spectral analysis, N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide C-NMR spectrum](https://i2.wp.com/pic11.molbase.net/nmr/nmr_image/2014-11-28/002/473/2473420_13c.png)
Example 5: Synthesis of N-[2-2[2(S)-Cyano pyrrolidin-l-yl]-2-oxoethyIamino]-2- methyIpropyl]-2-methyaIpyrazoIo [1, 5-a] pyrimidine-6-carboxamide (I, anagliptin).
1H NMR (300 MHz, CDC13): δ 1.16 (s, 6H), 2.23(m, 4H), 2.54(s, 3H), 3.25-3.51 (m, 6H), 4.78 (m, 1H), 6.53 (s, 1H), 8.05 (s, 1H), 8.93 (s, 1H), 9.22(s, 1H)
HPLC Purity: 99.71%, Chiral purity: 100%………WO2014147640A2
Kato, M.; Oka, M.; Murase, T.; Yoshida, M.; Sakairi, M.; Yamashita, S.; Yasuda, Y.; Yoshikawa, A.; Hayashi, Y.; Makino, M.; Takeda, M.; Mirensha, Y.;
Kakigami, T. Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-
2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective
DPP-IV inhibitor. Bioorg. Med. Chem. 2011, 19, 7221–7227.
http://www.sciencedirect.com/science/article/pii/S0968089611007784
LATUR, MAHARASHTRA, INDIA
http://en.wikipedia.org/wiki/Latur
| Latur लातूर Lattalur, Ratnapur |
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|---|---|
| City | |
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 Latur
Location in Maharashtra, India |
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| Coordinates: 18.40°N 76.56°ECoordinates: 18.40°N 76.56°E | |
| Country |  India |
| State | Maharashtra |
| Region | Aurangabad Division |
| District | Latur |
| Settled | Possibly 7th century AD |
| Government | |
| • Body | Latur Municipal Corporation |
| • Mayor | Akhtar Shaikh |
| Area[1] | |
| • Total | 117.78 km2(45.48 sq mi) |
| Area rank | 89 |
| Elevation | 515 m (1,690 ft) |
| Population (2011) | |
| • Total | 382,754 |
| • Rank | 89th |
| • Density | 3,200/km2(8,400/sq mi) |
| Demonym | Laturkar |
| Languages | |
| • Official | Marathi |
| Time zone | IST (UTC+5:30) |
| PIN |
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| Telephone code | 91-2382 |
| Vehicle registration | MH-24 |
| Sex ratio | 923.54 ♀/1000 ♂ |
| Literacy | 89.67 |
| Distance from Mumbai | 497 kilometres (309 mi) E (land) |
| Distance fromHyderabad | 337 kilometres (209 mi) NW (land) |
| Distance fromAurangabad, Maharashtra | 294 kilometres (183 mi) SE (land) |
| Climate | BSh (Köppen) |
| Precipitation | 666 millimetres (26.2 in) |
| Avg. summer temperature | 41 °C (106 °F) |
| Avg. winter temperature | 13 °C (55 °F) |
| http://www.citypopulation.de/world/Agglomerations.html | |
his Is The Famous ‘Ganj-Golai’ As The Central Place Of The Latur City. There Are 16 Roads Connecting To This Place And Seperate Markets i.e. Jewellers …
लातूर जिल्हयातील चित्र संग्रह
LATUR AIRPORT
LATUR AIRPORT
2012 Navratri Mahotsav in Latur
SOS Children’s Village Latur
Latur, India: Carnival Resort
Ausa Near Latur
Chakur near Latur
Vilasrao Deshmukh’s ancestral home at Babhalgaon village in Latur. Machindra Amle
UDGIR: Udgir is one of the most important towns of Latur district. Udgir has a great historical significance. It has witnessed the war between the Marathas …
The city of Latur is located in India’s welathiest state, Maharashtra. Together with many of the surrounding villages, Latur was all but destroyed in the
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