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Valdetamide

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CAS Registry Number: 512-48-1

CAS Name: 2,2-Diethyl-4-pentenamide

Additional Names: diethylallylacetamide

Trademarks: Novonal (Hoechst)

Molecular Formula: C9H17NO

Molecular Weight: 155.24

Percent Composition: C 69.63%, H 11.04%, N 9.02%, O 10.31%

Literature References: Description: Bockmühl, Schaumann, Dtsch. Med. Wochenschr. 54, 270 (1928). Pharmacokinetics and metabolism: H. Uehleke, M. Brinkschulte-Freitas, Arch. Pharmacol. 302, 11 (1978). TLC determn in urine: E. Klug, P. Toffel, Arzneim.-Forsch. 29, 1651 (1979).

Properties: White powder, mp 75-76°. Sol in 120 parts water; freely sol in alcohol, ether.

Melting point: mp 75-76°

Therap-Cat: Sedative, hypnotic.

Keywords: Sedative/Hypnotic; Amides.

Valdetamid (Valdetamide)

Structural formula

UV – spectrum

Conditions : Concentration – 50 mg / 100 ml
The solvent designation schedule methanol

Water

0.1 M HCl

0.1M NaOH

maximum absorption
ε

IR – spectrum

Wavelength (μm)
Wave number (cm -1 )

Range
10 largest peaks:
Peak 53 55 57 67 69 81 112 126 127 140
Value 152 848 115 141 929 156 286 999 338 238

References

  • UV and IR Spectra. H.-W. Dibbern, RM Muller, E. Wirbitzki, 2002 ECV

  • NIST / EPA / NIH Mass Spectral Library 2008

  • Handbook of Organic Compounds. NIR, IR, Raman, and UV-Vis Spectra Featuring Polymers and Surfactants, Jr., Jerry Workman.Academic Press, 2000.

  • Handbook of ultraviolet and visible absorption spectra of organic compounds, K. Hirayama. Plenum Press Data Division, 1967.

Brief background information

Salt ATC Formula MM CAS
N05C 9 H 17 NO 155.24 g / mol 512-48-1

Using

  • hypnotic

Classes substance

  • Amides

Synthesis Way

Synthesis of a)

Trade names

A country Tradename Manufacturer
Germany Arantxa Hoechst
Betadorm-H Woelm
insomnia ICN
Nokturetten Starke
New Dolestan Much
Ukraine no no

Formulations

  • dragees 50 mg;

  • 300 mg Tablets

References

  • DRP 473 329 (IG Farben; appl 1925.).

  • DRP 616 876 (IG Farben; appl 1930.).

  • DRP 622 875 (IG Farben; appl 1931.).

  • GB 253,950 (IG Farben; appl 1926;.. D-prior 1925).

1H NMR PREDICT

13C NMR PREDICT

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DR ANTHONY CRASTO

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 29 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 29 year tenure till date Aug 2016, Around 30 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 25 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 13 lakh plus views on New Drug Approvals Blog in 212 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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