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Sotradecol, Sodium tetradecyl sulfate



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Sodium 7-ethyl-2-methyl-4-undecanyl sulfate.svg
ChemSpider 2D Image | sodium tetradecyl sulfate | C14H29NaO4S


Sodium tetradecyl sulfate

cas 139-88-8, Na FORM

free form  300-52-7

  • Molecular FormulaC14H29NaO4S
  • Average mass316.432 Da

139-88-8 [RN], cas 1191-50-0,

4-Undecanol, 7-ethyl-2-methyl-, hydrogen sulfate, sodium salt (1:1)
7-Ethyl-2-methyl-4-undecyl sulfate sodium salt
натрия тетрадецилсульфат [Russian] [INN]
تتراديسيل سولفات صوديوم [Arabic] [INN]
十四烷硫酸钠 [Chinese] [INN]
CAS Registry Number: 139-88-8 
CAS Name: 7-Ethyl-2-methyl-4-undecanol hydrogen sulfate sodium salt 
Additional Names: 7-ethyl-2-methyl-4-hendecanol sulfate sodium salt; sodium 2-methyl-7-ethyl-4-undecyl sulfate; sodium 7-ethyl-2-methylundecyl-4-sulfate 
Trademarks: Sotradecol (Elkins-Sinn); Tergitol 4; Trombavar; Trombovar 
Molecular Formula: C14H29NaSO4, Molecular Weight: 316.43 
Percent Composition: C 53.14%, H 9.24%, Na 7.27%, S 10.13%, O 20.22% 
Properties: White, waxy solid. Sol in water, alcohol, ether. The pH of a 5% soln is from 6.5 to 9.0. Surface tension (dynes/cm) of aq soln at 25°: 56.5 dynes/cm (0.05% w/w); 52 (0.10%); 47 (0.20%); 40 (0.50%); 35 (1.0%). LD50 orally in rats: 4.95 g/kg, H. F. Smyth, C. P. Carpenter, J. Ind. Hyg. Toxicol.30, 63 (1948). 
Toxicity data: LD50 orally in rats: 4.95 g/kg, H. F. Smyth, C. P. Carpenter, J. Ind. Hyg. Toxicol.30, 63 (1948) 
Use: Wetting agent. 
Therap-Cat: Sclerosing agent., Keywords: Sclerosing Agent.

Synonyms of Sodium Tetradecyl Sulfate [INN]

  • 4-Ethyl-1-isobutyloktylsiran sodny
  • EINECS 205-380-3
  • Natrii tetracylis sulfas
  • Natrii tetradecylis sulfas
  • Natrii tetradecylis sulfas [Latin]
  • Natrii tetradecylsulfas
  • NSC 755887
  • Obliterol
  • Sodium sotradecol
  • Sodium tetradecyl sulfate
  • Sotradecol
  • Tergitol
  • Tergitol 4
  • Tergitol anionic 4
  • Tergitol penetrant 4
  • Tetradecilsulfato sodico
  • Tetradecilsulfato sodico [Spanish]
  • Tetradecyl sulfate de sodium
  • Trombovar
  • Varicol

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.


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Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. The structural formula is as follows:

SOTRADECOL (Sodium Tetradscyl Sulfate) structural formula illustration

C14H28NaS04       7-Ethyl -2-methyl -4-hendecanol sulfate sodium salt       MW 316.44Sotradecol® (sodium tetradecyl sulfate injection) is a sterile nonpyrogenic solution for intravenous use as a sclerosing agent.

1% (10 mg/mL): Each mL contains sodium tetradecyl sulfate 10 mg, benzyl alcohol 0.02 mL and dibasic sodium phosphate, anhydrous 4.0 mg in Water for Injection. pH 7.9; monobasic sodium phosphate and/or sodium hydroxide added, if needed, for pH adjustment.

3% (30 mg/mL): Each mL contains sodium tetradecyl sulfate 30 mg, benzyl alcohol 0.02 mL and dibasic sodium phosphate, anhydrous 9.0 mg in Water for Injection. pH 7.9; monobasic sodium phosphate and/or sodium hydroxide added, if needed, for pH adjustment.

Sodium tetradecyl sulfate (STS) is a commonly used synonym for 7-ethyl-2-methyl-4-undecanyl sulfate sodium salt[1] which is anionicsurfactant that is the active component of the sclerosant drug Sotradecol. It is commonly used in the treatment of varicose and spider veins of the leg, during the procedure of sclerotherapy.[2] Being a detergent, its action is on the lipid molecules in the cells of the vein wall, causing inflammatory destruction of the internal lining of the vein and thrombus formation eventually leading to sclerosis of the vein. It is used in concentrations ranging from 0.1% to 3% for this purpose. It is occasionally used for the treatment of stabilisation of joints that regularly dislocate, particularly in patients with Ehlers-Danlos syndrome.[3] In the UK, Ireland, Italy, Australia, New Zealand and South Africa, it is sold under the trade-name Fibro-Vein in concentrations of 0.2%, 0.5%, 1.0%, and 3%.[4]


It may be prepared by the aldol condensation of methyl isobutyl ketone and 2-ethylhexanal (which is itself formed by the aldol self-concensation of butyraldehyde), followed by sulfonation of the resulting alcohol.


RSC Advances, 10(22), 12788-12799; 2020


CN 106278961

CN 106278958

 U.S.S.R., 1051067,


Compound name:Sodium Tetradecyl Sulfate
Spectrum type:1H NMR Spectrum (1D, 400 MHz, DMSO-d6, experimental)


  1. ^ “SOTRADECOL® (Sodium tetradecyl sulfate)” (PDF). Retrieved 29 August 2014.
  2. ^ Jenkinson HA, Wilmas KM, Silapunt S (November 2017). “Sodium Tetradecyl Sulfate: A Review of Clinical Uses”. Dermatologic Surgery43 (11): 1313–1320. doi:10.1097/DSS.0000000000001143PMID 28430735.
  3. ^ Burling F (2019). “Comparison of tetradecyl sulfate versus polidocanol injections for stabilisation of joints that regularly dislocate in an Ehlers-Danlos population”BMJ Open Sport & Exercise Medicine5 (1): e000481. doi:10.1136/bmjsem-2018-000481PMC 6350757PMID 30792884.
  4. ^ Fibro-Vein history and details
Clinical data
Other names7-Ethyl-2-methyl-4-hendecanol sulfate sodium salt
AHFS/Drugs.comConsumer Drug Information
Routes of
Intravenous injection
ATC codeC05BB04 (WHO)
Legal status
Legal statusIn general: ℞ (Prescription only)
showIUPAC name
CAS Number139-88-8 
CompTox Dashboard (EPA)DTXSID3041530 
ECHA InfoCard100.004.892
Chemical and physical data
Molar mass316.43 g·mol−1
3D model (JSmol)Interactive image
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///////Sodium tetradecyl sulfate, sotradecol, Sclerosing Agent, varicose veins






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DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries...... , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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