A VAPOURTEC POST
http://www.vapourtec.co.uk/products/eseriessystem/pumping/organometallic
| Philip R D Murray 1 Duncan L Browne 1 Julio C Pastre 1,2 Chris Butters 3 Duncan Guthrie 3 Steven V Ley 1 |
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1 Department of Chemistry, University of Cambridge, UK
2 Instituto de Química, University of Campinas, Brazil
3 Vapourtec Ltd, UK
http://www.vapourtec.co.uk/products/eseriessystem/pumping/organometallic
A new enabling-technology for the pumping of organometallic reagents such as n-butyllithium, Grignard reagents and DIBAL-H is reported, which utilizes a newly developed chemically-resistant peristaltic pumping system. Several representative examples of its use in common transformations using these reagents, including metal-halogen exchange, addition, addition-elimination, conjugate addition and partial reduction are reported, along with examples of telescoping of the anionic reaction products. This platform allows for truly continuous pumping of these highly reactive substances and examples are demonstrated over periods of several hours, to generate multi-gram quantities of products. This work culminates in an approach to the telescoped synthesis of (E/Z)-Tamoxifen using continuous-flow organometallic reagent mediated transformations………..http://www.vapourtec.co.uk/products/eseriessystem/pumping/organometallic.
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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