Chemical structure of ganetespib and its co-crystal structure with Hsp90 N-terminal.
A, chemical structure of ganetespib.
B, crystallographic complex of ganetespib in the Hsp90 N-terminal.
C, hydrogen bond interactions between ganetespib with amino acid residues in the Hsp90 N-terminal ATP-binding pocket.
Synta Pharmaceuticals has opened a ClinicalTrials.gov listing for their much discussed GALAXY-2 phase 3 trial of their HSP90 inhibitor ganetespib in second-line non-small cell lung cancer (NSCLC), in combination with docetaxel. For the moment at least, the phase 2b GALAXY-1 trial is still listed as enrolling patients, but that would be expected to complete soon.
- CAS Number:
- Molecular Structure:
- Formula: C20H20N4O3
Hsp90, a chaperone essential for the folding of JAK2, is the target of Synta Pharmaceuticals’ ganetespib.