DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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Elfucose
Cas 87-96-7
Chemical Formula: C6H12O5
Exact Mass: 164.07
Molecular Weight: 164.157
L-fucopyranose (6-deoxy-L-galactopyranose)
(3S,4R,5S,6S)-6-methyloxane-2,3,4,5-tetrol
- 6-Deoxy-L-galactose (ACI)
- Fucose, L- (8CI)
- (-)-Fucose
- 46: PN: US20220380460 SEQID: 47 claimed sequence
- 6-Desoxygalactose
- L-(-)-Fucose
- L-Fucose
- L-Galactomethylose
- L-Galactopyranose, 6-deoxy-
- CERC 803
- Elfucose
- Fucose
- NSC 1219
- congenital glycosylation disorders
- 6-Deoxy-L-galactopyranose
- L-galactomethylose
- 87-96-7
- Fucose, L-
- 6-deoxy-galactose
Fucose is under investigation in clinical trial NCT03354533 (Study of ORL-1F (L-fucose) in Patients With Leukocyte Adhesion Deficiency Type II).
L-fucopyranose is the pyranose form of L-fucose. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a L-fucose and a fucopyranose.
SCHEME
PATENT
WO2016150629
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016150629&_cid=P10-MB1MYE-34318-1
Examples
The invention will now be illustrated in more detail by the following non-limiting examples.
Example 1: Production of L-fucose by biocatalytic oxidation of L-fucitol with galactose oxidase in the presence of peroxidase and catalase
A solution of L-fucitol (6.0 mL aqueous solution containing 600 mg L-fucitol, CAS 13074-06-1, Santa Cruz Biotechnology) was added to a round-bottom three-neck bottle (50 mL), followed by the addition of 1.2 mL K2HPO4 / KH2PO4 ( 1000 mM , pH=7.0) and 0.095 mL catalase (from bovine liver, SIGMA, 21,300 U/mg, 34 mg/mL), 0.120 mL peroxidase (from horseradish, 173 U/mg solid, SIGMA ) and 2.218 mL galactose oxidase (38.4 mg/mL, 2,708 U/mL). The resulting solution was purged with O 2 at room temperature until all L-fucitol was converted to L-fucose. The reaction was monitored by HLPC. The final product was isolated and analyzed by 1 H and 13C NMR. The results are summarized in Table 1.
[Table 1]
Reaction time [h] Conversion [%]
0
3,5 54,0
24 95,8
29 96,0
PATENT
WO2010022244
WO2007021879
////////////Elfucose, 6-Deoxy-L-galactose, Fucose, L- , (-)-Fucose, 6-Desoxygalactose, L-(-)-Fucose, L-Fucose, L-Galactomethylose, L-Galactopyranose, 6-deoxy-, CERC 803, Elfucose, Fucose, NSC 1219, congenital glycosylation disorders, 6-Deoxy-L-galactopyranose, L-galactomethylose, 87-96-7, Fucose, L-, 6-deoxy-galactose
New Drug Approvals 