July 8 2013 | By Márcio Barra
Novartis announced today that their experimental psoriasis drug secukinumab was more effective in a Phase III trial than Pfizer’s and Amgen’s Enbrel (Etarnacept) in clearing the skin of patients with moderate to severe plaque-type psoriasis.
The trial, called FIXTURE, is a pivotal trial intended for registration, where secukinumab was compared to both placebo and Enbrel. While final results will only be released later this year, secukinumab met all primary and secondary endpoints on the drug’s safety, tolerability and short term and long term efficacy parameters. Whether the findings will give secukinumab sufficient differentiation over the anti-TNF drugs – its ability to reduce the risk of severe infections compared with the anti-TNFs will be crucial – will become clearer when the data is released, possibly at the American College of Rheumatology in October
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