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Process Development for Low Cost Manufacturing



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Process Development for Low Cost Manufacturing on 23-24 nov 2015 , Hyderabad, INDIA

23.11.2015 – 24.11.2015


Hotel Green Park – Hyderabad, India
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Chemical process research and development is recognised as a key function during the commercialisation of a new product particularly in the generic and contract manufacturing arms of the chemical, agrochemical and pharmaceutical industries.

The synthesis and individual processes must be economic, safe and must generate product that meets the necessary quality requirements.

This 2-day course presented by highly experienced process chemists will concentrate on the development and optimisation of efficient processes to target molecules with an emphasis on raw material cost, solvent choice, yield improvement, process efficiency and work up, and waste minimisation.

Process robustness testing and reaction optimisation via stastical methods will also be covered.

A discussion of patent issues and areas where engineering and technology can help reduce operating costs.

The use of engineering and technology solutions to reduce costs will be discussed and throughout the course the emphasis will be on minimising costs and maximising returns.


    • Young Chemists who have just started work in industry as development chemists
    • Organic Chemists/Medicinal Chemists in Research and Development who would like to gain an appreciation of development and scale up and who are perhaps contemplating moving into chemical development.
    • Development and Production Chemists in industry who would like to improve their efficiency and gain an insight into alternative approaches to chemical development.
    • Chemical Engineers who wish to understand a chemist’s approach to chemical development of batch processes. (Engineers would, however, need a good grounding in organic chemistry)
    • Students who are about to enter the industry and can obtain company sponsorship.
    • Experienced Chemists looking to refresh and/or augment their knowledge of chemical development
    • Analytical Chemists who wish to gain a broader appreciation of process chemistry
    • Managers who might benefit from a comprehensive and up to date overview of chemical development

    • Introduction
      Route selection, raw material choice
      • Choosing the best route
      • Using the cheapest raw materials and reagents, back integration of raw material supply
      • Reducing the number of steps vs. reagent choice / yield and cost

      Solvent selection
      • Solvent cost, recyclability
      • Solvent reactivity and solvent swapping
      • Solvent choice for reaction and work up

      Reaction optimisation
      • Reaction understanding
      • Improving conversion, selectivity
      • Telescoping

      Process optimisation
      • Reaction quench
      • Work up
      • Product isolation (crystallisation, filtration and drying)

      Statistical methods of optimisation
      • Design of experiments
      • Factorial and fractional factorial design
      • Response surface analysis
      • Robustness testing

      Regulatory and Quality issues
      • Impurity control and tracking
      • Process validation and QbD
      • Vessel cleaning

      Patent issues
      • Patents basics
      • Patent definition
      • Where patents are in force
      • How to work around patents

      Use of technology and engineering
      • Flow chemistry
      • SMB chromatography
      • Separation technologies

      At the end of the course participants will have gained:

      • A logical investigative approach to chemical development and optimisation
      • An insight into the factors involved in development and scaleup
      • A preliminary knowledge of statistical methods of optimisation
      • Improved ability to decide which parts of the chemical process to examine in detail.
      • Ideas for efficient resource allocation
      • Improved troubleshooting and problem solving ability
      • A basic outline of the patent system
      • An appreciation of how to assess the main cost contributors in a process



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DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK LIFE SCIENCES LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 30 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. Radhakrishnan and Dr B. K. Kulkarni, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 30 PLUS year tenure till date June 2021, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 90 Lakh plus views on dozen plus blogs, 233 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 33 lakh plus views on New Drug Approvals Blog in 233 countries...... , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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