Process Development for Low Cost Manufacturing on 23-24 nov 2015 , Hyderabad, INDIA
- 23.11.2015 – 24.11.2015
- Hotel Green Park – Hyderabad, India
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Chemical process research and development is recognised as a key function during the commercialisation of a new product particularly in the generic and contract manufacturing arms of the chemical, agrochemical and pharmaceutical industries.
The synthesis and individual processes must be economic, safe and must generate product that meets the necessary quality requirements.
This 2-day course presented by highly experienced process chemists will concentrate on the development and optimisation of efficient processes to target molecules with an emphasis on raw material cost, solvent choice, yield improvement, process efficiency and work up, and waste minimisation.
Process robustness testing and reaction optimisation via stastical methods will also be covered.
A discussion of patent issues and areas where engineering and technology can help reduce operating costs.
The use of engineering and technology solutions to reduce costs will be discussed and throughout the course the emphasis will be on minimising costs and maximising returns.
- Young Chemists who have just started work in industry as development chemists
- Organic Chemists/Medicinal Chemists in Research and Development who would like to gain an appreciation of development and scale up and who are perhaps contemplating moving into chemical development.
- Development and Production Chemists in industry who would like to improve their efficiency and gain an insight into alternative approaches to chemical development.
- Chemical Engineers who wish to understand a chemist’s approach to chemical development of batch processes. (Engineers would, however, need a good grounding in organic chemistry)
- Students who are about to enter the industry and can obtain company sponsorship.
- Experienced Chemists looking to refresh and/or augment their knowledge of chemical development
- Analytical Chemists who wish to gain a broader appreciation of process chemistry
- Managers who might benefit from a comprehensive and up to date overview of chemical development
Route selection, raw material choice
• Choosing the best route
• Using the cheapest raw materials and reagents, back integration of raw material supply
• Reducing the number of steps vs. reagent choice / yield and cost
• Solvent cost, recyclability
• Solvent reactivity and solvent swapping
• Solvent choice for reaction and work up
• Reaction understanding
• Improving conversion, selectivity
• Reaction quench
• Work up
• Product isolation (crystallisation, filtration and drying)
Statistical methods of optimisation
• Design of experiments
• Factorial and fractional factorial design
• Response surface analysis
• Robustness testing
Regulatory and Quality issues
• Impurity control and tracking
• Process validation and QbD
• Vessel cleaning
• Patents basics
• Patent definition
• Where patents are in force
• How to work around patents
Use of technology and engineering
• Flow chemistry
• SMB chromatography
• Separation technologies
At the end of the course participants will have gained:
• A logical investigative approach to chemical development and optimisation
• An insight into the factors involved in development and scaleup
• A preliminary knowledge of statistical methods of optimisation
• Improved ability to decide which parts of the chemical process to examine in detail.
• Ideas for efficient resource allocation
• Improved troubleshooting and problem solving ability
• A basic outline of the patent system
• An appreciation of how to assess the main cost contributors in a process