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DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

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ORGANIC SPECTROSCOPY

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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Alcon announces FDA approval of Simbrinza(TM) Suspension


20/04/2013

Alcon, the global leader in eye care and a division of Novartis, announces US FDA approval for Simbrinza(TM) Suspension, indicated for the reduction of elevated intraocular pressure (IOP) in patients with primary open-angle glaucoma or ocular hypertension.

Elevated IOP is the only modifiable risk factor for glaucoma. Glaucoma is a group of eye diseases that lead to progressive damage of the optic nerve[5] and can result in gradual, irreversible loss of vision, and eventually blindness, if left untreated. Glaucoma affects more than 2.2 million Americans and is the second-leading cause of preventable blindness worldwide, according to Novartis AG.
Simbrinza is a fixed-dose combination medication that offers a wide range of treatment possibilities due to its strong efficacy and ability to decrease elevated IOP by 21- 35%. In addition, it is the only available, fixed-dose combination therapy for glaucoma in the US without a beta blocker.

read all at

http://www.informazione.it/c/0143881B-8C8A-4886-B9CC-D6352299B0B4/Alcon-announces-FDA-approval-of-SimbrinzaTM-Suspension-a-new-beta-blocker-free-fixed-combination-therapy-for-glaucoma-patients

COMPANIES – India’s Orchid links up with new antibiotics firm Allecra


Indian drugmaker Orchid Pharma has bought a stake in a newly-formed European firm, Allecra Therapeutics, which has been set up to develop novel antibiotics…………………READ MORE AT PHARMATIMES

http://www.pharmatimes.com/Article/13-04-19/India_s_Orchid_links_up_with_new_antibiotics_firm_Allecra.aspx

Links

www.allecra.com
www.orchidpharma.com

The Chennai-based pharmaceuticals major, Orchid Chemicals & Pharmaceuticals Ltd,  With exports spanning more than 75 countries, it is the largest manufacturer-exporter of cephalosporin bulk actives in India and is ranked amongst the top 5 cephalosporin-producers globally.

Orchid is a first-generation enterprise founded in 1992 by K Raghavendra Rao, who is also the firm’s managing director.——- READ MORE

http://www.rediff.com/money/2004/apr/07spec.htm

Orchid Pharma MD K Raghavendra Rao

HOMEOPATHY- BOTHROPS for thrombosis


Bothrops

 

Yellow pit viper / Fer de lance

Bothrops lanceolatus / Lachesis lanceolatus

 

The homeopathic remedy bothrops is prepared using the freshly obtained venom of bothrops lanceolatus and it is mainly used to cure thrombosis (intravascular coagulation of blood in any part of the circulatory system) and hemorrhages.

 

Belonging to a genus of venomous pit vipers that are found in Central and South America, Bothrops contains a heat-sensitive pit on both sides of its head. The generic name bothrops has its origin in the Greek words bothrops denoting ‘pit’ and ‘ops’ meaning ‘eye’ or ‘face’ – a reference to the heat-sensitive organs on its head. Compared to any other group of venomous snakes, members of this genus are liable for more number of snake-bite deaths in the Americas. As of date, 32 species of snakes in this genus have been identified.

 

It may be noted that the yellow pit viper is a highly poisonous snake and its bite may prove to be fatal for humans. This species is distinguished by its gray or brown color and a series of black-edged diamonds, which usually have a paler shade along the border. Anyone suffering a yellow pit viper bite on a limb experiences rapid swelling of the part, so much so that it becomes enormous in size. At the same time, the limb is infected along with the formation of gangrene.

 

The yellow pit viper is a very violent and extremely poisonous snake that is indigenous to the island of Martinique. The highly poisonous snake, which belongs to the family of Crotalidae, is commonly known as the Martinique lance head or fer-de-lance.

 

Usually, a large, semi-arborial and heavy-bodied Martinique lance head adult is about 150 cm to 200 cm, however, there have been instances when snakes as long as 300 cm too have been sighted. The color of this species body ranges from gray to brown to yellowish tan and usually has marked darker patterns on the back as well as laterally. The top of the lance head’s head generally has a darker color. The color of the belly region of the snake varies from a paler yellowish-gray to grayish-brown. In the case of some snakes, the belly region is also freckled with small, relatively darker grayish marks.

 

The yellow pit viper or bothrops lanceolatus is mainly found in humid tropical forests as well as tropical soggy forest in the highlands. Sometimes, this species is also found inhabiting the stony hillsides. Previously, this species was found in a number of other Caribbean islands, but now it is only found on Martinique island, on land ranging from the sea level to about 1,300 m height.

 

Although the yellow pit viper is generally a nocturnal species and primarily land-dwelling, some members of this species have also been found living at a height of 20 meters above the ground. As mentioned before, the yellow pit viper or bothrops lanceolatus is a very aggressive snake and has the ability to attack swiftly when it is taken aback or endangered. This species is known to be ovoviviparous (producing eggs and hatching them inside the body), but the size of the litter has not yet been reported. This species of snakes mainly feeds of birds, lizards, small mammals that are available to it and also frogs.

 

The venom of bothrops lanceolauts is basically hemotoxic (a poison that results in hemolytic reactions), usually with cytotoxic (a substance poisonous to living cells) aspects. Envenomation or the injection of this snake’s venom is likely to cause regular internal bleeding and at the same time, damage the local tissues. Several deaths of humans owing to bites by bothrops lanceolauts (B. lanceolauts) have been kept in details.

 

Parts used

 

The homeopathic remedy bothrops is prepared from the freshly obtained venom of the poisonous snake bothrops lanceolauts or the yellow pit viper found in the South and Central America. Although this homeopathic medication is prepared from deadly snake venom, it does not retain any of the toxic or poisonous attributes of the substance it is made from and is absolutely safe for human use.

 

Uses

 

Unlike most other homeopathic medications, bothrops has limited therapeutic uses. This homeopathic remedy is primarily used to treat thrombosis or hemorrhaging. In addition, bothrops may also be given to patients who have suffered strokes on the left side along with paralysis on the right side and enduring incapability to be eloquent or memorize the right words. Generally, individuals needing this homeopathic medication are somewhat slow or tired and they also experience trembling due to nervousness.

 

There are no specific factors that are known to make people bitten by the yellow pit viper feel better or improve their symptoms. On the other hand, they feel worse or their symptoms deteriorate when they are walking, on their right side or taking a deep breath. In addition, their condition worsens after midnight and also at sunrise.

 

Source

 

The yellow pit viper or bothrops lanceolatus, whose venom forms the basis of the homeopathic remedy bothrops, is found on the Martinique Island in the Caribbean. Earlier, this species was also found on several other islands of the Caribbean. This species is an Ophidian belonging to the Crotalidae family. Bothrops lanceolatus is a highly aggressive snake and its venom is extremely poisonous.

HOMEOPATHY-REVIEW


Samuel Hahnemann, the founder of homeopathy

Homeopathy uses very dilute substances to stimulate the body’s healing power. Its basic principle is treat ‘like with like’. This involves treating a patient’s symptoms with minute amounts of a substance that would cause similar symptoms in a healthy person. This practice contrasts with conventional allopathic medicine, in which treating ‘like with opposite’ prevails; that is, a disease is treated with a substance that opposes it.

The first person to practise the healing principle of treating ‘like with like’ was Greek physician Hippocrates (c.460-377BCE). His method went against the thinking of the time, which held that the gods were the main force behind a disease, and that a cure could be found by treating with a substance that had an opposite effect in a healthy person.

German doctor Samuel Hahnemann (1755-1843) was the modern-day founder of homeopathy. He proved the principle of ‘like curing like’ with his experiments with quinine, known to be an effective treatment for malaria. He found he developed malarial symptoms after taking doses of quinine (he was otherwise in good health). These effects lasted hours after each dose.

He tested other substances in the same way, in a process known as ‘proving’. He ‘proved’ more than 100 homeopathic remedies in his lifetime, publishing his findings in ‘The Organon of Rational Medicine’ in 1811. He believed that the remedies worked by activating a person’s ‘vital force’, that is, the body’s own healing potential. Having conducted tests on many volunteers, he came to realise the importance of taking into account the personality traits of each person receiving the treatment. He found that particular ‘types’ of people manifested different symptoms to the same disease and so required treatment with different remedies in accordance with their ‘type’.

American doctor James Tyler Kent (1849-1943) furthered Hahnemann’s work on the different ‘types’ of people and the matching of a remedy to their emotional and physical characteristics. These ‘types’ became known as ‘constitutional types’.

Homeopathic remedies

Remedies can be made from many different substances. The most common sources are flowers, plants, roots, trees, poisons, minerals and metals. Certain insects are also used. Hahnemann used the smallest possible amount of a substance to trigger a healing effect. This was to minimise side effects. He realised that the more a substance was diluted, the better the results, provided it was also vigorously shaken (in a process known as succussion) at each stage of dilution. Counter­intuitive though it seems, the less of the original substance that remained in the remedy, the greater its potency and effectiveness. The process of diluting a remedy to render it effective is called potentisation. First an alcohol/water extract is made from the substance. This is the mother tincture. The extract is diluted to the required potency.

Old homeopathic belladonna remedy.

The main potencies are denoted by x, c and m: x means the remedy has been diluted one part mother tincture in 9 drops of water; c means one part of mother tincture in 99 drops of water; and m means one part of mother tincture in 999 drops of water. A 1c potency is one part in 99 parts of water. A 2c potency is created by taking one part of the previous dilution (i.e., the 1c potency) and diluting it in 99 parts of water. The most common potencies used are 6c, 12c and 30c.

Once the required potency is reached, a few drops of the substance are applied to lactose (milk sugar) tablets. The tablets must be kept dry and away from direct sunlight. For the purposes of self-treatment as detailed here, it is suggested that the 30c potencies are used, as these are commonly available. To obtain the best results, consult a homeopath. They may prescribe higher potencies depending on the initial consultation and the presenting problem. This is particularly the case if the ailment has a strong emotional or mental aspect.

1857 painting by Alexander Beydeman showing historical figures and personifications of homeopathy observing the brutality of medicine of the 19th century

Homeopathic pills, homeopathic remedy oscillococcinum

Historical context

Hippocrates, in about 400 BC, perhaps originated homeopathy when he prescribed a small dose of mandrake root – which in larger doses produced mania – to treat mania itself; in the 16th century the pioneer of pharmacology Paracelsus declared that small doses of “what makes a man ill also cures him.” Samuel Hahnemann (1755–1843) gave homeopathy its name and expanded its principles in the late 18th century. At that time, mainstream medicine used methods like bloodletting and purging, and administered complex mixtures, such as Venice treacle, which was made from 64 substances including opium, myrrh, and viper’s flesh. These treatments often worsened symptoms and sometimes proved fatal. Hahnemann rejected these practices – which had been extolled for centuries as irrational and inadvisable; instead, he advocated the use of single drugs at lower doses and promoted an immaterial, vitalistic view of how living organisms function, believing that diseases have spiritual, as well as physical causes.

Homeopathic remedy Rhus toxicodendron, derived from poison ivy.

Lilly’s diabetes drug dulaglutide shines again in Phase III


Lilly's diabetes drug dulaglutide shines again in Phase III

STRUCTURAL FORMULA OF DULAGLUTIDE
Monomer
HGEGTFTSDV SSYLEEQAAK EFIAWLVKGG GGGGGSGGGG SGGGGSAESK 50
YGPPCPPCPA PEAAGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSQEDP 100
EVQFNWYVDG VEVHNAKTKP REEQFNSTYR VVSVLTVLHQ DWLNGKEYKC 150
KVSNKGLPSS IEKTISKAKG QPREPQVYTL PPSQEEMTKN QVSLTCLVKG 200
FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT VDKSRWQEGN 250
VFSCSVMHEA LHNHYTQKSL SLSLG 275
Disulfide bridges location
55-55′ 58-58′ 90-150 90′-150′ 196-254 196′-254′
MOLECULAR FORMULA C2646H4044N704O836S18
MOLECULAR WEIGHT 59.67 kDa

MANUFACTURER Eli Lilly and Company
CODE DESIGNATION LY2189265
CAS REGISTRY NUMBER 923950-08-7

http://www.ama-assn.org/resources/doc/usan/dulaglutide.pdf      FOR ALL DATA

Dulaglutide

APRIL 17, 2013

Eli Lilly has presented more promising late-stage data on its investigational long-acting diabetes drug dulaglutide.

The US major has presented top-line results from two Phase III studies from the five-trial AWARD programme. The first showed that dulaglutide demonstrated statistically superior reduction in HbA1c (blood sugar) levels compared to Sanofi’s Lantus (insulin glargine) at 52 weeks in patients with type 2 diabetes who were on metformin and glimeperide (AWARD-2). The second trial demonstrated that the drug, a once-weekly glucagon-like peptide 1 (GLP-1) receptor agonist, in combination with Lilly’s own Humalog (insulin lispro) was more effective than a Lantus/Humalog combo.

In October, Lilly posted impressive data from three other AWARD trials which showed that dulaglutide controlled HbA1c levels better than Byetta (exenatide), a drug Lilly helped develop before ending a collaboration with Amylin (since bought by Bristol-Myers Squibb and AstraZeneca), metformin and Merck & Co’s Januvia (sitagliptin).

Lilly stated that it expects to submit dulaglutide to regulatory authorities this year and present detailed data from the AWARD studies at scientific meetings in 2013 and 2014.

DRUG SPOTLIGHT- EXENATIDE, BYETTA


EXENATIDE

ACETATE CAS NO 141732-76-5

Exenatide, derived from a compound found in the saliva of the Gila monster, a large lizard native to the southwestern US, is a functional analog of Glucagon-Like Peptide-1 (GLP-1), a naturally occuring peptide.

Exenatide (INN, marketed as ByettaBydureon) is a glucagon-like peptide-1 agonist(GLP-1 agonist) medication approved in April 2005 for the treatment of diabetes mellitus type 2. It belongs to the group of incretin mimetics and is manufactured by Amylin Pharmaceuticals. Exenatide in its Byetta form is administered as a subcutaneous injection (under the skin) of the abdomen, thigh, or arm, any time within the 60 minutes before the first and last meal of the day. A once-weekly injection has been approved as of January 27, 2012 under the trademark Bydureon

Exenatide is a synthetic version of exendin-4, a hormone found in the saliva of the Gila monster that was first isolated by Dr. John Eng in 1992 while working at the Veterans Administration Medical Center in the Bronx, New York. It displays biological properties similar to human glucagon-like peptide-1 (GLP-1), a regulator of glucose metabolism andinsulin secretion. According to the package insert, exenatide enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying, although the mechanism of action is still under study.

Exenatide is a 39-amino-acid peptide, an insulin secretagogue, with glucoregulatory effects. Exenatide was approved by the FDA on April 28, 2005 for patients whose diabetes was not well-controlled on other oral medication. The medication is injected subcutaneously twice per day using a filled pen-like device. The abdomen is a common injection site, after the area is cleaned with an alcohol pad. A new pen must first be tested to see if the medicine is flowing.

Gila monster

GILA MONSTER

Indication Indicated as adjunctive therapy to improve glycemic control in patients with Type 2 diabetes mellitus who are taking metformin, a sulfonylurea, or a combination of both, but have not achieved adequate glycemic control.
Pharmacodynamics Exenatide is an incretin mimetic, which has glucoregulatory effects. While it is has blood-sugar lowering actions alone, it can also be combined with other medications such as pioglitazone, metformin, sulfonylureas, and/or insulin to improve glucose control. The approved use of exenatide is with either sulfonylureas, metformin and thiazolinediones. The medication is injected twice per day using a pre-filled pen device. Typical human responses to exenatide plus eating include improvements in the initial rapid release of endogenous insulin, suppression of glucagon release by the pancreas, regulation of gastric empyting and reduced appetite; all behaviors more typical of individuals without blood sugar control problems. Exenatide is self-regulating in that in lowers blood sugar when levels are elevated but does not continue to lower blood sugar when levels return to normal, unlike with sulfonylureas or insulins.
Mechanism of action Exenatide is a functional analog of the human incretin Glucagon-Like Peptide-1 (GLP-1). Incretins enhance glucose-dependent insulin secretion and exhibit other antihyperglycemic actions following their release into the circulation from the gut. The GLP-1 system increases insulin secretion only in the presence of elevated plasma glucose levels, avoiding inappropriately high insulin levels during fasting. The drug also moderates peak serum glucagon levels during hyperglycemic periods following meals, but does not interfere with glucagon release in response to hypoglycemia. Secondary effects of drug administration reduces the rate of gastric emptying and decreases food intake, mitigating the potential severity of hyperglycemic events after meal
Following subcutaneous administration to patients with type 2 diabetes, exenatide reaches median peak plasma concentrations in 2.1 hours.

ARAB MEDICINE- Alyeadah (Teucrium Stocisianum Bois)


Tree Germander (Teucrium fruticans)

This plant is used in folk medicine for treating diarrhea, cough, jaundice and abdominal pain

Medicinal plants are used for the treatment of different diseases in almost all cultures. Teucrium species grow wildly at different geographical locations around the world. Teucrium stocksianum is used in folk medicine for the treatment of diarrhea, cough, jaundice and abdominal pain. Scientific study on Teucrium stocksianum shows that it possesses anthelmintic, cytotoxic and antispasmodic activity. The aim of our present study is to identify the chemical composition and antinociceptive potential of the essential oil extracted from Teucrium stocksianum bioss.

Teucrium is a genus of perennial plants in the family Lamiaceae. The name is believed to refer to King Teucer of Troy. Members of the genus are commonly known as germanders. These species are herbs, shrubs or subshrubs. They are most common in Mediterranean climates.

An unusual feature of this genus compared with other members of Lamiaceae is that the flowers completely lack the upper lip of the corolla, although it is somewhat reduced also in other genera (Ajuga among them).

Several species are used as food plants by the larvae of some Lepidoptera species including the Coleophora case-bearers Coleophora auricella and Coleophora chamaedriella. The latter is only known from Wall Germander (T. chamaedrys).

Teucrium species are rich in essential oils. They are valued as ornamental plants and a pollen source, and some species have culinary and/or medical value.

CHINESE HERBS-Ginkgo biloba for libido


Ginkgo biloba Ginkgo biloba L.

Ginkgo biloba L.
Ginkgo leaves
Common Names
Ginkgo biloba
Botanical Name
Ginkgo biloba L.
Family
GINKGOACEAE The Ginkgo family

Traditional Chinese Medicine traditional Chinese medicine The earliest know reference to ginkgo is in the Chinese Materia Medica, in apx 2,800 B.C and the seeds and root have been used in TCM for thousands of years to combat mental decline. (Ginkgo Biloba Leaf)

Ginkgo (Ginkgo biloba; in Chinese and Japanese 銀杏, pinyin romanization: yín xìng, Hepburn romanization: ichō or ginnan), also spelled gingko and known as the maidenhair tree, is a unique species of tree with no close living relatives. The ginkgo is a living fossil, recognisably similar to fossils dating back 270 million years. Native to China,the tree is widely cultivated and was introduced early to human history. It has various uses in traditional medicine and as a food.

Sexual function and responsiveness are very dependent on the supply of blood to the genital organs. In particular, enhanced blood flow to the penis can do much to improve a man’s ability to attain and maintain an erection. In this respect, the herb ginkgo biloba has much to offer.

Renowned as a circulation enhancer, ginkgo biloba was found in one study to benefit 78 per cent of men with impotence. The dose used in this study was 80mg of ginkgo biloba extract, three times a day. The beneficial effects of ginkgo biloba may take three or more months to become apparent.

Ginkgo biloba may have significant benefits for women too. There is growing awareness that improved blood supply to the female sexual organs can do much to enhance sexual sensation. While this has not been studied specifically, I have seen several patients who have experienced a subjective enhancement in sexual pleasure on taking ginkgo biloba in the long term.

The ginkgo is the oldest living tree species, geological records indicate this plant has been growing on earth for 150 – 200 million years. Chinese monks are credited with keeping the tree in existence, as a sacred herb. It was first brought to Europe in the 1700’s and it is now a commonly prescribed drug in France and Germany. It is one of the most well-researched herbs in the world.
The oldest tree species in the world, dating from the time of the dinosaurs, Ginkgo biloba (bi-loba, two sided leaf) is the last remaining species of the Ginkgoales order. Fossil records show the species was once widespread in Asia and North America, and it is speculated that it was saved from extinction by monks in the far east who cultivated it secretly as a sacred tree.

Ginkgo leaves in summer

Each tree can live for more than a thousand years, immune to bugs, disease and pollution. The tree grows to 100 feet tall and has fan-like leaves and yellow-green fetid smelling fruits. If you are lucky enough to have access to a mature tree, take advantage of the fresh leaves, which contain the broadest spectrum of medicinal properties. In the last 30 years, more that 300 studies have given clinical evidence that ginkgo prevents and benefits many problems throughout the entire body. Ginkgo is gaining recognition as a brain tonic that enhances memory because of its positive effects on the vascular system, especially in the cerebellum. It is also used as a treatment for vertigo, tinnitus (ringing in the ears) and a variety of neurological disorders and circulation problems. Ginkgo may help to counteract the effects of aging, including mental fatigue and lack of energy.

Pollen cones
Ovules

The use of the ginkgo leaf is recent, and has been studied for its cardiovascular benefits. Today ginkgo biloba is one of the most commonly prescribed herbs and is a great example of a tonic herb – one that balances whatever is going on in your system; if you are tired it can energize you, if you are stressed it will relax you.

The bilobalides, ginkgolides, flavonoids, and other substances unique to the tree restore better blood flow to all parts of the body but particularly to the brain, allowing improved use of oxygen. Ginkgo’s antioxidant actions also stabilize the structure of brain and nerve cells and protect them from oxidative attacks from free radicals. Research indicates ginkgo action of supporting healthier circulation in the eyes, make it an herb of choice for natural treatment eye health and macular degeneration.

Ginkgo works by increasing blood flow to the brain and throughout the body’s network of blood vessels that supply blood and oxygen to the organ systems. It increases metabolism efficiency, regulates neurotransmitters, and boosts oxygen levels in the brain which uses 20% of the body’s oxygen.


Benefits of enhanced circulation in the brain include improved short and long term memory, increased reaction time and improved mental clarity. Ginkgo is often used to treat elderly persons with Alzheimer’s and other symptoms of cerebral insufficiency. Cerebral insufficiency is a general term for a collection of symptoms that include difficulties of concentration and memory, absentmindedness, confusion, lack of energy, depressive mood, anxiety, dizziness, tinnitus, and headache.
Ginkgo constituents are beneficial for a variety of imbalances and deterioration in the brain and body. Standardized ginkgo extract inhibits platelet activity factor (PAF), which is a common allergen in the body. Physical stress, and poor quality food can overstimulate PAF production; in other words, blood clotting. Excessive PAF can help cause cardiovascular disease, brain damage, hearing disorders and other immune and inflammatory diseases.


Ginkgo has been used to relieve tension and anxiety and improve mental alertness, elevate mood and restore energy.
Ginkgo has two groups of active substances, flavonoids and terpene lactones, including ginkgolides A, B, and C, bilobalide, quercetin, and kaempferol. The ginkgolides have been shown to control allergic inflammation, anaphylactic shock and asthma.
Ginkgo also acts as a powerful antioxidant and contributes to the oxidation of free radicals which are believed to contribute to premature aging and dementia. Antioxidants also protect the eyes, cardiovascular system and central nervous system.
Ginkgo may also help control the transformation of cholesterol to plaque associated with the hardening of arteries, and can relax constricted blood vessels.
The herb has been used in treatment of other circulation-related disorders such as diabetic peripheral vascular disease, Raynaud’s syndrome, hemorrhoids and varicose veins. It can also aid in the treatment of insufficient circulation and complications from stroke and skull injuries. Ginkgo’s beneficial effects on the circulatory system also can be of benefit in the treatment of eye and ear disorders.
Studies have confirmed that ginkgo increases blood flow to the retina, and can slow retinal deterioration resulting in an increase of visual acuity. In clinical tests ginkgo has improved hearing loss in the elderly. It also improves circulation in the extremities relieving cold hands and feet, swelling in the limbs and chronic arterial blockage. Among other things, ginkgo is being investigated as a potential treatment to prevent the rejection of transplanted organs, as a treatment for asthma and for toxic shock syndrome.
Parts Used: Dried leaf.
Common Use: Ginkgo has been shown to be nutritional support for mental alertness, enhanced vitality level, circulatory health and blood vessel health. Its high antioxidant activity is valuable for fighting age related conditions. All over the world, people have claimed Ginkgo to be beneficial in the fight against the gradual erosion of energy associated with aging.
Care: The ginkgo tree thrives in full sun and average soil. It is very resistant to infection and pollution and can grow up to 120 feet. The small yellow fruit that falls from the female tree has a strong rancid odor

ARAB MEDICINE- REVIEW


Arab medicine

In the history of medicine, Islamic medicine, Arabic medicine, Greco-Arabic and Greco-Islamic refer to medicine developed in the Islamic Golden Age, and written in Arabic, the lingua franca of Islamic civilization. The emergence of Islamic medicine came about through the interactions of the indigenous Arab tradition with foreign influences.Translation of earlier texts was a fundamental building block in the formation of Islamic medicine and the tradition that has been passed down.

Latin translations of Arabic medical works had a significant influence on the development of medicine in the high Middle Ages and early Renaissance, as did Arabic texts which translated the medical works of earlier cultures.

In the early Islamic and Mack’s period (661–750 AD), Muslims believed that Allah provided a treatment for every illness.Around the ninth century, the Islamic medical community began to develop and utilize a system of medicine based on scientific analysis. The importance of the health sciences to society was emphasized, and the early Muslim medical community strived to find ways to care for the health of the human body. Medieval Islam developed hospitals, expanded the practice of surgery.

Important medical thinkers and physicians of Islam were Al-Razi and Ibn Sina. Their knowledge on medicine was recorded in books that were influential in medical schools throughout Muslim history, and Ibn Sina in particular (under his Latinized name Avicenna) was also influential on the physicians of later medieval Europe. Throughout the medieval Islamic world, medicine was included under the umbrella of natural philosophy, due to the continued influence of the Hippocratic Corpus and the ideas of Aristotle and Galen. The Hippocratic Corpus was a collection of medical treatises attributed to the famous Greek physician Hippocrates of Cos (although it was actually composed by different generations of authors). The Corpus included a number of treatises which greatly influenced medieval Islamic medical literature

The first encyclopedia of medicine in Arabic language] was Persian scientist Ali ibn Sahl Rabban al-Tabari‘s Firdous al-Hikmah (“Paradise of Wisdom”), written in seven parts, c. 860. Al-Tabari, a pioneer in the field of child development, emphasized strong ties between psychology and medicine, and the need for psychotherapy and counseling in the therapeutic treatment of patients. His encyclopedia also discussed the influence of Sushruta and Chanakya on medicine, including psychotherapy

Medical contributions made by Medieval Islam not only involved the development and expansion of the human anatomy, but also included the use of plants as a type of remedy or medicine. Medieval Islamic physicians used natural substances as a source of medicinal drugs—including Papaver somniferum Linnaeus, poppy, and Cannabis sativa Linnaeus, hemp. In pre-Islamic Arabia, neither poppy nor hemp was known. Hemp was introduced into the Islamic countries in the ninth century from India through Persia and Greek culture and medical literature. Dioscorides, who according to the Arabs is the greatest botanist of antiquity, recommended hemp’s seeds to “quench geniture” and its juice for earaches.[27] Beginning in 800 and lasting for over two centuries, poppy use was restricted to the therapeutic realm. However, the dosages often exceeded medical need and was used repeatedly despite what was originally recommended. Poppy was prescribed by Yuhanna b. Masawayh to relieve pain from attacks of gallbladder stones, for fevers, indigestion, eye, head and tooth aches, pleurisy, and to induce sleep. Although poppy had medicinal benefits, Ali al-Tabari explained that the extract of poppy leaves was lethal, and that the extracts and opium should be considered poisons

The way early Arab medicine developed should be contrasted to how medicine evolved in Christianity up until the Renaissance. While Christian Rome and Byzantium inherited the rich Graeco-Roman medical legacy of thinkers like Hippocrates and Galen, after the fall of Rome in 476, Dark Age Europe increasingly tended towards a fatalistic view of suffering and disease, further tempered by superstition about curses and God’s punishment for man’s sins sent down in the form of disease and affliction.

Many historians point to the explicit tradition of fact-based, scientific medicine as articulated by the Prophet himself (pbuh). First, the concept of ‘sinful’ mankind seems not as strong in Islam as in early Christianity. Disease was seen by Arabs and other Muslims as one more problem to be solved, not a curse from God or a trial to be endured so one would be assured of entering Paradise.

Consider these statements on health and medicine attributed to the Prophet (pbuh):

“There is no disease that Allah has created, except that He also has created its treatment.”

“Make use of medical treatment, for Allah has not made a disease without appointing a remedy for it, with the exception of one disease, namely old age.”

The Prophet (pbuh) was also credited with articulating several specific medical treatments, including the use of honey, cupping, and cauterisation. He spoke about the contagious nature of leprosy, sexually transmitted disease, and the animal disease known as the mange. But most importantly, whereas other societies usually stigmatised and feared the sick and afflicted, at best isolating them and at worst leaving them somewhere to die, the Prophet (pbuh) and early Islam had a very compassionate and forgiving view of the sick.

As in other fields, the earliest Arab-Muslim medical efforts were devoted to translating the medical wisdom of older civilisations, beginning in the late 700s in Baghdad with the works of the Roman physician Galen as well as advanced medical writings from Persia, including the great pre-Islamic medical centre at Gundishapur.

Gundishapur is credited with having developed the first truly modern hospital, where patients actually went to be healed and cured, rather than prayed over as they suffered a slow and inevitable death as in Dark Age Europe.

The first major Arab-Muslim healer was the chemist Al Razi, who turned to medicine at about age 30, perhaps to find cures for his injuries suffered during alchemical experiments, especially eye ailments. His first inspiration was the Roman physician Galen.

Galen had pushed Roman medical knowledge as far as it could go in that time, undertaking innumerable vivisections of live animals to see how their organs functioned, as well as dissections of human cadavers.

Al Razi was especially troubled by Galen’s theory of the humours, which just didn’t hold up to examination. There seemed a lot more going on inside the human body than those four humours. And so he would write around 865:

“I prayed to God to direct and lead me to the truth in writing this book. It grieves me to oppose and criticise the man Galen from whose sea of knowledge I have drawn much. Indeed, he is the Master and I am the disciple. Although this reverence and appreciation will and should not prevent me from doubting, as I did, what is erroneous in his theories. I imagine and feel deeply in my heart that Galen has chosen me to undertake this task, and if he were alive, he would have congratulated me on what I am doing. I say this because Galen’s aim was to seek and find the truth and bring light out of darkness. I wish indeed he were alive to read what I have published.”

Al Razi would write as many as 184 papers and articles on subjects ranging from his doubts about Galen to the first known distinction between smallpox and measles, the discovery of allergic asthma, the discovery of fever as the body’s defence mechanism, medical ethics, using opium as a treatment for depression, the first medical handbook for common people, and paediatrics.

Al Razi would also theorise about the connection of the soul and state of mind to the physical health of the body, suggesting that someone with mental and emotional disturbances would be more vulnerable to infection and chronic ailments.

Al Razi’s medical insights would be translated into Latin several centuries after his death. By the late 1200s, mediaeval Europeans were beginning to stir out of their long Dark Age sleep and for a century were captivated by the writings of Al Razi – who by then had been given the Latin name Rhazes.

About eight decades after Al Razi, a brilliant healer named Al Zahrawi laid the foundation of modern surgery while working in the Umayyad imperial compound outside Cordoba.

Because all records were destroyed in the civil wars that marked the end of the Umayyad reign in Spain, hardly any facts about Al Zahrawi’s personal life remain. What does survive is his 30-chapter Kitab al Tasrif, a compendium of this man’s medical knowledge and genius. A century and a half after his death, it would be translated into Latin and have even more impact than the work of Rhazes. Al Zahrawi’s Latin name was Albucasis.

His discoveries would continue to resonate into the 21st century, first for his invention of about 200 medical instruments, many of which are still in use – such as the obstetrical forceps, scalpel, surgical needle, surgical retractor, specula, and the use of catgut for internal suturing. But he was also exceptional for innovating surgical procedures like mastectomies, orthodontia, repairing fractures, and using ligature for suturing arteries instead of cauterising them.

Another Muslim healer would follow in the Arabic tradition and even eclipse the great Al Zahrawi, this one a Persian working exclusively in Persia. This man was Ibn Sina. Europe and the Arab world would come to know him as Avicenna, the Prince of Medicine, and the single most important influence on Islamic and Western medicine for about 500 years.

Ibn Sina was consummately gifted. He is reputed to have memorised the Qur’an by age 10, Aristotle’s Metaphysics several years later (he claimed to have read it 40 times), and had become a practising physician by age 16.

Ibn Sina’s greatest motivation was his burning intellectual curiosity for the world, and the world beyond, not social status or financial security. By the age of 20, he had turned down his ruler’s offer to become court physician, preferring only the right to study as much as he wanted in the ruler’s royal library.

A political upheaval overthrew the ruler and Ibn Sina began a long life of wandering Persia in search of a secure patron who would allow him to indulge in his medical and scientific research. Unfortunately, political instability and Ibn Sina’s harshly arrogant manner meant he was constantly changing jobs.

But despite his unending struggle, he was able to gradually systemise Islamic understanding of the medical sciences in such a way that not only was the Arab and Islamic world forever indebted, so also was Europe and the West.

Although Ibn Sina is credited with writing as many as 450 papers and books in a dozen fields, the work that continued to resonate most powerfully was his Canon of Medicine written around 1025, a 14-volume work that was for 500 years Europe’s most influential medical source book. The Canon was a combination both of the collected medical wisdom of other writers as well as his own observations and research. Although it provided a window into forgotten Greek medicine, its greatest value was in the modernistic approach it took to a field riddled with false theory and ignorance.

It could be argued that Ibn Sina was the first to formally explain the experimental method in medicine, the spread of contagious diseases, the use of quarantine, clinical trials, psychiatry, and psychotherapy. He also seems to be the first to show that tuberculosis was a contagious disease, as well as to identify diabetes.

According to some sources, the Canon was the first documented explanation of modern medical methods like the randomised clinical trial, and the first modern set of comprehensive rules for testing new drugs.

His deeper research into the mind-body connection, and the mental or spiritual source of physical ailments, was built on the first intuitive work of men like Al Razi. But Ibn Sina went further, beginning the first documented forays into what we today would call psychotherapy, 900 years before Sigmund Freud.

One account says that a young man had come to him with a condition that looked very much like consumption. He was literally wasting away. But Ibn Sina could find no signs of a cancer or other disease that would indicate some physical explanation.

He conducted a series of interviews or conversations with the young man. As Ibn Sina spoke certain key words and phrases, he was also checking the man’s pulse and found it became elevated around certain terms. Thus it gradually emerged that the patient was in love with a woman back in his home village. For whatever reason he had never expressed this to her, and the unfulfilled desire was sapping him of his energy.

Ibn Sina gradually concluded that the source of the young man’s physical condition was his unexpressed love. He suggested that the patient go to the object of his affections and profess his love to her. The young man did this, the girl agreed to marry him, and the patient swiftly recovered his vitality.

As far as we know this was the earliest documented account of the use of word association in psychoanalysis, which modern medicine credits to Carl Jung 900 years later.

While medical thinkers like Al Razi, Al Zahrawi and Ibn Sina are closely tied to their innovations through their writings, many of the great breakthroughs of Arab medicine were collective undertakings and are difficult to identify with any single author or inventor.

This is particularly true with key Arab-Muslim institutions like the modern insane asylum, the public hospital, free medical care, and the pharmacy. The modern hospital itself was not an Arab invention, but Arabs and their partners made it a public institution and spread it around the world.

Isolated healing temples and places for the sick had existed in many older cultures including around the Mediterranean and across Asia. But with few exceptions they were unable to offer real cures in the modern sense. Often their method was a mixture of magic or religion with means of making one feel better, if only briefly.

But in 6th century pre-Islamic Persia, a true hospital called a bimaristan or ‘sick place’ was built in the city of Gundishapur, complete with surgery, pharmacy, and outpatient treatments. This came to the attention of the Arabs, in particular Caliphs Harun Al Rashid and his half-Persian son Al Mamun, and they set about replicating these institutions across their realm.

Harun invited a doctor from the bimaristan in Gundishapur to open the first bimaristan in Baghdad. Al Razi was later commissioned with overseeing the Audidi Hospital in Baghdad, in the mid 800s. He applied his evolving understanding of sanitation and infection to find the best location possible. He hung raw meat in various parts of the city to see comparative rates of decay, and where the meat lasted longest, there he put the hospital.

Audidi had more than two dozen doctors including surgeons, eye specialists, and physiologists.

By the year 1000, Baghdad alone would number five public hospitals when there were none in all of Europe. Hospitals would also be found in Cairo, Damascus, Aleppo, North Africa, and Al Andalus. These centres would offer surgery, outpatient clinics, mental wards, convalescent centres, and even nursing homes.

One of the greatest hospitals would be Al Mansuri in Cairo, which was reported to have as many as 8,000 beds and annual revenues of one million dirhams. Al Mansuri was a true public hospital because it was charged with offering treatment to anyone, rich or poor, including the indigent who could not pay at all.

The Arab establishment of humane mental wards and insane asylums was especially futuristic and important. The Arab world, in line with the teachings of the Prophet (pbuh) and others, never stigmatised the mentally afflicted, seeing mental illness as one more disease that might be cured. Europe and the West did not develop a modern non-judgmental view of mental illness until the 19th and 20th centuries.

Arab pharmacies were another important invention. Although other cultures offered various potions and herbs for sale, it was rare to find cures that really worked. People were just as inclined to faith healing and magic as to ‘healing’ substances, because they were all equally ineffective. But the evolution of modern evidence-based pharmacology under thinkers like Al Razi, Al Kindi and Ibn Sina created a new class of substances that really worked.

Arab pharmacies were known as saydala, and the first one seems to have been at Harun al Rashid’s hospital in Baghdad built in the late 700s. Within half a century saydala were spreading throughout the caliphate. These remedies were often fabricated right on the spot at in-house laboratories. More importantly, they were overseen by government inspectors to make sure they were pure, not out of date, measured in verified scales, and correctly identified.

Al Razi would even introduce the concept of generic drugs for the poor, while Al Kindi would also seek to identify cheaper alternative treatments for those who could not afford expensive drugs.

The same kind of modern pharmacies selling remedies that really worked would only begin to appear in Italy in about the 12th century, fuelled largely by the growing trade between Arabs and Europeans.

READ A GREAT ARTICLE AT

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297506/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475945/

Aqrabadhin of Al-Kindi. Translated by Martin Levey. Madison: The University of Wisconsin Press, 1966.

Kamal, Hassan. Encyclopedia of Islamic Medicine. Cairo: General Egyptian Book Organization, 1975.

Levey, Martin. Early Arabic Pharmacology. Leiden, Netherlands: E. J. Brill, 1973.

Savage-Smith, Emilie. Islamic Culture and the Medical Arts. Bethesda, Md.: National Library of Medicine, 1994.

Siddiqi, Muhammad Zubayr. Studies in Arabic and Persian Medical Literature. Calcutta: Calcutta University Press, 1959.

Usama, Ibn Shuraik. Sunna Abu-Dawud, Book 28, No. 3846 (part of the hadith, a narrative record of the sayings of Mohammed and his companions).

FDA Advisory Committee Recommends Approval of BREO(TM) ELLIPTA(TM) for the Treatment of COPD


04/17/13

GlaxoSmithKline plc  and Theravance, Inc. today announced that the Pulmonary-Allergy Drugs Advisory Committee (PADAC) to the US Food and Drug Administration (FDA) voted that the efficacy and safety data provide substantial evidence to support approval of BREO™ ELLIPTA™ as a once-daily inhaled treatment for the long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD) (9 for, 4 against) and also for the reduction of COPD exacerbations in patients with a history of exacerbations (9 for, 4 against)*.
BREO™ ELLIPTA™, is the proposed proprietary name for FF/VI 100/25 mcg, a combination of the inhaled corticosteroid (ICS) fluticasone furoate “FF”and the long acting bronchodilator (LABA) vilanterol “VI” (FF/VI)……………….read more at pharmalive

http://www.pharmalive.com/fda-panel-backs-glaxos-breo-ellipta

fluticasone furoate

vilanterol