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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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Sanofi Pasteur Initiates Phase III Study of Investigational Clostridium difficile Vaccine in the United States

August 6, 2013 1:00 am / 2 Comments on Sanofi Pasteur Initiates Phase III Study of Investigational Clostridium difficile Vaccine in the United States

Cdiffense trial to evaluate vaccine against a leading cause of life-threatening, healthcare-associated infections worldwide

SWIFTWATER, Pa., Aug. 5, 2013 /PRNewswire/ — Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: SAN and NYSE: SNY), announced today the initiation of its Phase III clinical program called Cdiffense to evaluate the safety, immunogenicity and efficacy of an investigational vaccine for the prevention of primary symptomatic Clostridium difficile infection (CDI). Clostridium difficile (C. diff) is a potentially life-threatening, spore-forming bacterium that causes intestinal disease. The risk of C. diff increases with age, antibiotic treatment and time spent in hospitals or nursing homes, where multiple cases can lead to outbreaks. The investigational vaccine is designed to help protect at-risk individuals from C. diff, which is emerging as a leading cause of life-threatening, healthcare-associated infections (HAIs)worldwide, read all at…………….

http://www.pharmalive.com/sanofi-starts-phase-iii-trial-for-clostridium-difficile-vaccine

…

New Findings Could Influence Development of Therapies to Treat Dengue Disease

August 5, 2013 3:02 pm / 1 Comment on New Findings Could Influence Development of Therapies to Treat Dengue Disease

Bristol, UK (Scicasts) – New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.

The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry August 2 show that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.

read all at scicasts

http://scicasts.com/proteomics/2043-protein-functions/6391-new-findings-could-influence-development-of-therapies-to-treat-dengue-disease

Dengue from Siddharth Goyal

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Dengue Fever Power Point from orlandito12

World Drug Tracker: Korean Cuisine to Burn Fat and Cholesterol

August 5, 2013 12:58 pm / 1 Comment on World Drug Tracker: Korean Cuisine to Burn Fat and Cholesterol

World Drug Tracker: Korean Cuisine to Burn Fat and Cholesterol.

Health Animation – Patent Ductus Arteriosus (PDA) » All About Drugs

August 5, 2013 12:45 pm / Leave a comment

Health Animation – Patent Ductus Arteriosus (PDA) » All About Drugs.

7 Ways of Boosting Your Metabolism » All About Drugs

August 5, 2013 12:43 pm / Leave a comment

7 Ways of Boosting Your Metabolism » All About Drugs.

The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight

August 5, 2013 7:00 am / 56 Comments on The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight


Kokum fruits, seeds, pulp and rinds.jpg

The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight. The Department of Physiology researchers at the Georgetown University Medical Center in Washington DC, called Vrikshamla a safe, natural supplement for normal weight support. In an eight-week study of 60 volunteers, they reported Vrikshamla’s effectiveness in supporting normal weight, cholesterol, triglyceride and serum lipid levels.

hydroxycitric acid (HCA)

Vrikshamla grows in India the evergreen forests of the Western Ghats, the Southern Konkan region and in Goa. It is also cultivated in the Southern districts of Maharashtra and on the lower slopes of the Nilgiris mountains.

Active constituents:

The active constituent in this herb, HCA, helps weight loss by promoting normal appetite levels and by reducing the body’s ability to form adipose (fatty) tissue. HCA also reduces blood lipid levels and naturally lowers cholesterol. Other useful phytochemicals in Vrikshamla are garcinol, isogarcinol, xanthochymol and isoxanthochymol.

Herb Functions:

Weight management: The herb known to slow down the body’s ability to store fat, potentially enabling more fat from foods to pass through the body without being stored. Additionally, HCA blocks the production and storage of fat and cholesterol when calorie consumption exceeds healthy levels. The herb is also known to reduce blood lipid levels and to naturally lower cholesterol.

read at

http://www.himalayahealthcare.com/products/pharmaceuticals/vrikshamla.htm

Garcinia indica, a plant in the mangosteen family (Clusiaceae), commonly known askokum, punar puli (tulu language), is a fruit-bearing tree that has culinary, pharmaceutical, and industrial uses.

The genus Garcinia, belonging to the family Clusiaceae, includes about 200 species found in the Old World tropics, mostly in Asia and Africa. Garcinia indica is indigenous to theWestern Ghats region of India located along the western coast of the country. Of the 35 species found in India, 17 are endemic. Of these, seven are endemic to the Western Ghats, six in the Andaman and Nicobar Islands and four in the northeastern region of India.

Garcinia indica is found in forest lands, riversides and wastelands. These plants preferevergreen forests, but sometimes they also thrive in areas with relatively low rainfall. It is also cultivated on a small scale. It does not require irrigation, spraying of pesticides or fertilizers.

Garcinia indica is known by various names across India, including aamsol, aamsul, bindin, biran, bhirand,bhrinda, brinda, bin’na, kokum (alternate spellings kokam and cocum), katambi, looikya, sour apple, panarpuli, ratamba, thekera (in Assam) and many others.

The dried skin of kokum fruits

The outer cover of fruit is dried in the sun to get aamsul or kokam. It is used as a slightly sour spice in recipes from Maharashtra. Kokum yields a peculiar flavour and blackish red colour. It is a preferred substitute for tamarind in curries and other dishes from the Konkanregion. It is also used in cuisine from Gujarat, where it is frequently used to add flavor and tartness to dal (lentil soup) for flavor balance, and parts of South India.

The vessel on the left contains syrup which is obtained from the vessel containing kokum rinds, on the right. The syrup is used to make kokum sherbet

Kokum squash or kokum concentrate is used in preparing a drink (sherbet) which is bright red in colour. Kokum sherbet improves digestion and cools the body during summers^{[citation needed]}.

Further, the extract/ concentrate of this fruit is called aagal in Konkani and Marathi. It is to added during the preparation of solkadhi, along with coconut milk.

Industrial uses

The seed of Garcinia indica contains 23–26% oil, which remains solid at room temperature. It is used in the preparation of confectionery, medicines and cosmetics.

Recently, industries have started extracting hydroxycitric acid (HCA) from the rind of the fruit.^{[citation needed]}

The tree is ornamental, with a dense canopy of green leaves and red-tinged, tender, young leaves. The oily extract called kokum tel is used in foot massage.

Vivimed Acquires A US FDA Approved Formulation Manufacturing Facility

August 5, 2013 5:06 am / 1 Comment on Vivimed Acquires A US FDA Approved Formulation Manufacturing Facility

Managing Director and CEO Santosh Varalwar, vivimed labs ltd

Vivimed Labs Ltd, established in 1989, is a diversified global company with a unique portfolio of products in Specialty Chemicals and Pharmaceuticals. Vivimed has gradually increased its portfolio of offerings through product innovations at its Research & Development Center. Some of its reputed clientele includes Unilever, P&G, L’Oreal, ISP, Novartis, Merck, Cipla, Astra Zeneca, BDF, AVON and others. The Product offerings comprises Hair care, Skincare, Oral Care, Antimicrobials & Preservatives, Photo Imaging Chemicals & Photo Chromic, Specialized Formulations such as Opthalamic, Anti Ulcer, Antehelminth and other health care segments

1 aug 2013

Vivimed Labs Ltd., manufacturer of specialty chemicals and pharmaceuticals, announced the signing of an agreement to acquire Actavis Pharma Manufacturing Pvt. Ltd.’s solid oral dosage facility in Alathur in Tamil Nadu for an aggregate consideration of Rs.122 crore.

The facility is being acquired from its parent Actavis Holding Asia B.V., an affiliate of Actavis Inc., a leading global general and specialty pharmaceutical company.

read at

http://pharmadeals.pharmaintellect.com/2013/08/vivimed-acquires-us-fda-approved.html?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+Pharmainvest+%28PharmaInvest%29

Flow synthesis for Novartis anticancer drug, Gleevec, Imatinib

August 5, 2013 4:24 am / 4 Comments on Flow synthesis for Novartis anticancer drug, Gleevec, Imatinib

The flow-based route required minimal manual intervention and was achieved despite poor solubility of many reaction components

21 January 2013Michael Parkin

http://www.rsc.org/chemistryworld/2013/01/flow-synthesis-anticancer-drug

UK chemists have used a combination of flow chemistry methods with solid-supported scavengers and reagents to synthesise the active pharmaceutical ingredient, imatinib, of the anticancer drug Gleevec. The method avoids the need for any manual handling of intermediates and allows the drug to be synthesised in high purity in less than a day.

Gleevec, developed by Novartis, is a tyrosine kinase inhibitor used for the treatment of chronic myeloid leukaemia and gastrointestinal stromal tumours.

READ ALL AT

http://www.rsc.org/chemistryworld/2013/01/flow-synthesis-anticancer-drug



IMATINIB

CREDIT

http://www.veomed.com/va041542042010

‘Wrapping’ Gleevec Fights Drug-Resistant Cancer, Study Shows

http://www.sciencedaily.com/releases/2007/05/070501115127.htm

The anti-cancer drug Gleevec® is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area. This image shows the bandage (black box) on the modified version of the drug, WBZ-7. (Credit: Image courtesy of Rice University)

A new study in Cancer Research finds that the anti-cancer drug Gleevec® is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area.

FDA Grants Priority Review To New Drug Application For MNK-795

August 5, 2013 3:13 am / 3 Comments on FDA Grants Priority Review To New Drug Application For MNK-795

FDA Grants Priority Review To New Drug Application For MNK-795 Submitted By Depomed Licensee Mallinckrodt

Controlled Substance Analgesic Combination Product Uses Depomed’s Proprietary Acuform® Technology

NEWARK, Calif., July 29, 2013 /PRNewswire/ — Depomed, Inc. (NASDAQ:DEPO) announced today that the U. S. Food and Drug Administration (FDA) has accepted for filing a New Drug Application (NDA) from Mallinckrodt (NYSE: MNK) for MNK-795. MNK-795 is a controlled-release oral formulation of oxycodone and acetaminophen that has been studied for the management of moderate to severe acute pain where the use of an opioid analgesic is appropriate. MNK-795 is formulated with Depomed’s Acuform® drug delivery technology.

http://www.pharmalive.com/fda-grants-priority-review-to-new-drug-application-for-mnk-795

Considerations in the clinical development of biotech medicines

August 4, 2013 7:09 am / 1 Comment on Considerations in the clinical development of biotech medicines

DRUG REGULATORY AFFAIRS INTERNATIONAL

http://www.topra.org/sites/default/files/regrapart/1/4844/regrap-january2012-development-biotech-medicines.pdf

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Active constituents:

Herb Functions:

Industrial uses

The tree is ornamental, with a dense canopy of green leaves and red-tinged, tender, young leaves. The oily extract called kokum tel is used in foot massage.

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‘Wrapping’ Gleevec Fights Drug-Resistant Cancer, Study Shows

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