Hi Everyone, I have really been appreciating the visits to my blog. I had resurrected this dormant site blog a while ago and hoped I could get a fair number of visits. I have been overwhelmed with the response. Some of the posts were clear winners, like the Revlimid case, for sure. I, recently, came across this review in Organic Process Research & Development and realized there probably would be two sides to this argument.
Late-stage fluorination. The current review in OPRD can be found at Michael G. Campbell and Tobias Ritter*, “Late-Stage Fluorination: From Fundamentals to Application”, Org. Process Res. Dev. 2014, 18, 474−480
I remember, many years ago, discussing this with a colleague about adding a fluorine group to a molecule. We both agreed that it would be far better to add a fluorine early on the synthesis, so if there were side-products, you would…
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