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Barley Grass Inhibits 73% of Leukemia Cells in Vitro

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Barley Grass Inhibits 73% of Leukemia Cells in Vitro: An extract of green barley grass (Hordeum vlgare L.) powder was shown to inhibit the proliferation of human leukemia cells (Nalm-6) by up to 73% in vitro, and killed 62% of the cancer cells outright via apoptosis and necrosis. The barley grass extract also potently inhibited three other types of leukemia cells, while leaving healthy non-cancerous cells alone. What’s really interesting with this study is that the extract was prepared from a common green barley powder supplement which was purchased at an online supplement retailer in the USA. This was the first-ever study to show the anti-leukemia activity of green barley. Barley contains several unique compounds with potent anti-cancer effects such as the peptide lunacin, immune-stimulating glucans, and ribosome inactivating protein conjugates. Past studies have shown mature barley to be active against melanoma and cancers of the breast, skin, colon, liver, and lung. While mature barley contains gluten (albeit less than wheat), barley grass should be gluten-free if harvested before any seeds are produced. And since younger plants often contain much higher concentrations of healthy phytochemicals and enzymes than the mature versions, barley grass might be a highly beneficial superfood for reducing cancer risk and supporting overall health.<br /><br />
#Barley #Leukemia #Lymphoma<br /><br />
http://www.ncbi.nlm.nih.gov/pubmed/24039967

Barley Grass Inhibits 73% of Leukemia Cells in Vitro: An extract of green barley grass (Hordeum vlgare L.) powder was shown to inhibit the proliferation of human leukemia cells (Nalm-6) by up to 73% in vitro, and killed 62% of the cancer cells outright via apoptosis and necrosis.

The barley grass extract also potently inhibited three other types of leukemia cells, while leaving healthy non-cancerous cells alone. What’s really interesting with this study is that the extract was prepared from a common green barley powder supplement which was purchased at an online supplement retailer in the USA. This was the first-ever study to show the anti-leukemia activity of green barley.

Barley contains several unique compounds with potent anti-cancer effects such as the peptide lunacin, immune-stimulating glucans, and ribosome inactivating protein conjugates. Past studies have shown mature barley to be active against melanoma and cancers of the breast, skin, colon, liver, and lung. While mature barley contains gluten (albeit less than wheat), barley grass should be gluten-free if harvested before any seeds are produced.

And since younger plants often contain much higher concentrations of healthy phytochemicals and enzymes than the mature versions, barley grass might be a highly beneficial superfood for reducing cancer risk and supporting overall health.

http://www.ncbi.nlm.nih.gov/pubmed/24039967

 

 

What is Lunasin?

Lunasin is a soy peptide that exhibits health promoting characteristics. Scientific evidence indicates that Lunasin is a key component in soy protein responsible for its cholesterol-lowering properties. Lunasin is a unique, 43 chain amino acid peptide found within soybeans. Recent research and development surrounding this soy peptide focuses on promotion of healthy cholesterol levels. In addition to lunasin exhibiting cholesterol lowering properties, research shows it also has cancer preventive properties.

 

Abstract 10693: Identification of Lunasin as the Active Component in Soy Protein Responsible for Reducing LDL Cholesterol and Risk of Cardiovascular Disease by Alfredo F Galvez, Missouri Plant Science Center, Mexico, MO

In the above referenced report, published by the American Heart Association, Dr Galvez notes that the FDA had originally approved the health claim that soy reduced LDL cholesterol and CVD risk, and then recinded part of that claim.  The confusion, he notes, came from the lack of understanding at the time about what in the soy created the benefits the original research had shown.  In the intervening years, he and his team had tested the hypothesis that the lunasin peptide was the active component in soy protein responsible for lowering LDL cholesterol.

What he found was that lunasin lowers LDL cholesterol levels by stopping the gene  responsible from being active – it covers it over, and opens the genes that cover cholesterol management in the liver that had gotten covered by environmental and lifestyle-induced damage.

The lunasin soy peptide binds specifically to histone H3 and inhibits H3-Lysine 14 acetylation by PCAF histone acetylase enzyme. Transcriptional activation of HMG Co-A reductase, the rate-limiting enzyme for cholesterol biosynthesis requires the specific acetylation of histone H3 by PCAF. By inhibiting PCAF acetylation of H3-Lysine 14, lunasin was show to significantly reduce HMG Co-A reductase expression in HepG2 liver cells grown in cholesterol-free media. Westerns and RT-PCR experiments also revealed that the presence of lunasin increases LDL receptor expression, which can be attributed to the coordinate increase in expression of SP1 co-transcriptional activator.

Based on these results, his team found a way to extract the active lunasin from the rest of the soy.  This lunasin-enriched soy extract (LSE) contained 100-200 fold more bioactive lunasin than soy protein isolates.  Then they tested the LSE pigs bred to have high LDL cholesterol due to mutations in their LDL receptor genes. The pigs were fed casein-based diets and after two weeks their casein diet was supplemented with 250 mg LSE everyday for eight weeks. Results showed that casein diet increased LDL cholesterol levels in the LDL-R mutant pigs by an average of 6.7%. The addition of 250 mg of LES in casein diet reduced LDL cholesterol by 8.6% and and 6.4% after 4 and 8 weeks of treatment, respectively.

These results prove that lunasin is the active nutrient in soy protein responsible for LDL cholesterol lowering and its mechanism of action is by reducing cholesterol biosynthesis in the liver.

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DR ANTHONY CRASTO

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 30 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. Radhakrishnan and Dr B. K. Kulkarni, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 30 year tenure till date Dec 2017, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 50 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 19 lakh plus views on New Drug Approvals Blog in 216 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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