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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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Enrupatinib

January 20, 2026 2:32 am / Leave a comment


Enrupatinib

CAS 2222689-47-4

MF C27H26N6O3 MW 482.5 g/mol

6-[3-methoxy-4-[(6-methyl-3-pyridinyl)methoxy]anilino]-3-morpholin-4-ylquinoxaline-5-carbonitrile

colony-stimulating factor 1 receptor (CSF1R) inhibitor, antineoplastic, EI 1071, EI-1071, 9L35RVQ9J6

ENRUPATINIB is a small molecule drug with a maximum clinical trial phase of II and has 1 investigational indication.

EI-1071 is a selective Colony Stimulating Factor-1 Receptor kinase inhibitor.

  • A Study to Evaluate the Safety, Tolerability and Amount of EI-1071 in Blood in Healthy VolunteersCTID: NCT04238364Phase: Phase 1Status: CompletedDate: 2025-02-25
  • A Phase 2 Study to Assess the Safety of EI-1071 and the Effects of EI-1071 on Neuroinflammation in Alzheimer’s Disease PatientsCTID: NCT06745583Phase: Phase 2Status: RecruitingDate: 2025-07-28
  • OriginatorElixiron Immunotherapeutics
  • Developer4B Technologies; Elixiron Immunotherapeutics
  • ClassAntidementias; Antineoplastics; Small molecules
  • Mechanism of ActionMacrophage colony-stimulating factor receptor antagonists
  • Phase IIAlzheimer’s disease
  • Phase IAmyotrophic lateral sclerosis; Giant cell tumour of tendon sheath
  • No development reportedBreast cancer; Colorectal cancer
  • 27 Jul 2025Pharmacodynamics data from preclinical studies in Alzheimer’s disease presented at the Alzheimer’s Association International Conference 2025 (AAIC-2025)
  • 20 Dec 2024Phase-II clinical trials in Alzheimer’s disease (Treatment-experienced) in Taiwan (PO) (NCT06745583)
  • 28 Jul 2024Adverse event data from a phase I trial in Alzheimer’s disease presented at the Alzheimer’s Association International Conference 2024 (AAIC-2024)

SYN

PAT

https://patentscope.wipo.int/search/en/detail.jsf;jsessionid=FF56F70B79B734C8ED557D6943D76B2E.wapp1nC?docId=WO2025067450&_cid=P12-MKLYYQ-95450-1

PAT

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018071348&_cid=P12-MKLZ1L-03304-1

PAT

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////////enrupatinib, ANAX, colony-stimulating factor 1 receptor (CSF1R) inhibitor, antineoplastic, EI 1071, EI-1071, 9L35RVQ9J6