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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 36Yrs Exp. in the feld of Organic Chemistry,Working for AFRICURE PHARMA as ADVISOR earlier with GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, NO ADVERTISEMENTS , ACADEMIC , NON COMMERCIAL SITE, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution, ........amcrasto@gmail.com..........+91 9323115463, Skype amcrasto64 View Anthony Melvin Crasto Ph.D's profile on LinkedIn Anthony Melvin Crasto Dr.

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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Recent Posts

Impotence: When You Can’t Get It Up is Getting You Down


neilbaum's avatarDr. Neil Baum's Urology Blog

Probably nothing devastates a man more than having a failure in the bedroom. Impotence or erectile dysfunction affects nearly 33 million men in the United States. You are not alone. Help is available for nearly every man who has erectile dysfunction.
Diet
According to the Urology Channel’s “Erectile Dysfunction: Natural/Alternative Treatments,” erectile dysfunction can be treated by eating right, drinking plenty of water and avoiding sugar, dairy and caffeine. They recommend to eat whole, fresh, unrefined and unprocessed foods, including vegetables, whole grains, soy, beans, seeds, nuts, olive oil and cold-water fish such as salmon and tuna.
Taking your vitamins can also help; the Urology Channel suggests supplements such as flaxseed, and in particular vitamins C, E and the mineral zinc. These vitamins and supplements help bolster the vascular system, which is an important part of good sexual health.


Exercise
Since sexual health relies on the vascular system, a strong heart…

View original post 638 more words

Ayurvedic Management of Chronic Colds, Flu, Ear Nose & Throat Problems


Alex Duncan's avatarAlex's Ayurveda & Life Blog

This protocol assumes that you do not have access to Ayurvedic clinical treatments. Please also note that this article may be too complex for the general public. If you have studied Ayurveda, you will be more familiar with the terms and basic concepts.

The main treatments are dietary, lifestyle and herbal. Treatment should begin with Langhana (reducing) then move towards Brimhana (nourishing).

FOUNDATION (DOSHA/AGNI/AMA)

#1 Balance the Doshas

Reduce causal Dosha accumulation in inner pathway + reduce/balance Bodaka/Avalabbaka.

Start with diet & lifestyle.

Dietshould have most offending Kapha aggravating foods removed but also adapt to causal Dosha if it is not Kapha.

  • All animal and dairy foods should be stopped along with wheat and all sweeteners.
  • Any Ama forming food should be avoided.
  • Eat lightly. Fast if possible (if not too weak), otherwise cooked whole grains and steamed vegetables with spices is perfect.
  • Foods that are helpful: Cabbage, Garlic…

View original post 1,673 more words

Joint Pain: Medicine Kit of the Lower Pecos, Part II


Mary S. Black's avatarMary S. Black

Human beings have been plagued with joint pain throughout the history of mankind.  Arthritis, the condition caused by the wearing down of beneficial cartilage in the joints, affects over 27 million people in the United States today, according to the Arthritis Foundation

(www.arthritistoday.org). I don’t know enough about the skeletal evidence from the Lower Pecos of Texas to do more than speculate, but at least some people in the region 4000-6000 years ago must have worn out a knee or two climbing up and down steep canyons and running over rough stone outcroppings in the uplands. In other words, they probably had  their share of  “archaic arthritis.”

Ow! Even that phrase hurts!  Osteoarthritis produces stinging pain and can cause swelling and stiffness in the joints affected. Generally, the older you are, the more wear and tear you have on your joints.  A stiff knee could make a thirty-year-old adult from the archaic period feel…

View original post 703 more words

Benefits of Nettle plant


Drug development can be a gas


Pharmaceutical and biotech industries are heavily dependent on gas mixtures to grow biological cultures

The pharmaceutical and biotech industries rely heavily on industrial gases for applications such as supercritical fluid chromatgraphy and lyophilisation. Gas supply systems theefore need to offer high purity and traceability through the supply chain

http://www.manufacturingchemist.com/technical/article_page/Drug_development_can_be_a_gas/87137

Novartis Japan Achieves Primary Endpoint In HER2 Positive Advanced Breast Cancer Phase III Afinitor Trials


Everolimus

Novartis announced it achieved its primary endpoint of significantly extending progression-free survival with Afinitor (everolimus) in Phase III trials of patients with HER2 positive advanced breast cancer.

read all at

http://www.bioportfolio.com/news/article/1492876/Novartis-Japan-Achieves-Primary-Endpoint-In-HER2-Positive-Advanced-Breast-Cancer-Phase.html

Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR).

It is currently used as an immunosuppressant to prevent rejection of organ transplants and treatment of renal cell cancer and other tumours. Much research has also been conducted on everolimus and other mTOR inhibitors for use in a number of cancers.

It is marketed by Novartis under the tradenames Zortress (USA) and Certican (Europe and other countries) in transplantation medicine, and Afinitor in oncology.

GSK’s Votrient meets primary objective in Phase III ovarian cancer trial


pazopanib

GlaxoSmithKline’s (GSK) Votrient (pazopanib) has met the primary objective of a statistically significant improvement in the time to disease progression or death that is the progression-free survival (PFS) against placebo in Phase III ovarian cancer..

http://clinicaltrials.pharmaceutical-business-review.com/news/gsks-votrient-meets-primary-objective-in-phase-iii-ovarian-cancer-trial-030613

Pazopanib (trade name Votrient) is a potent and selective multi-targeted receptortyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. It has been approved for renal cell carcinoma and soft tissue sarcoma by the U.S. Food and Drug Administration.Pazopanib may also be active in ovarian cancer Pazopanib also appears effective in the treatment of non-small cell lung carcinoma.

 

New Drug Target Identified For Treating Deadly Form Of Leukemia


Dr Sharon Lim (left), first author of the study published in PNAS, with Prof Ong Sin Tiong, principal investigator.

A research team in Singapore has identified a promising drug target for the treatment of patients with terminal-stage chronic myeloid leukemia (CML).

AsianScientist (Jun. 4, 2013) – A research team in Singapore has identified ways to inhibit the function of a key protein linked to stem cell-like behavior in terminal-stage chronic myeloid leukemia (CML). The discovery makes it possible to develop drugs that may extend the survival of patients suffering from this deadly form of leukemia.read all this at

http://www.asianscientist.com/in-the-lab/new-drug-target-deadly-form-leukemia-2013/

New Rule on Importing Active Pharmaceutical Ingredients (API) to the EU


READ ALL AT

http://ec.europa.eu/health/files/documents/active_pharmaceutical_

ingredients_leaflet_en.pdf

 

by WORLD DRUG TRACKER

DR ANTHONY CRASTO

 

New Drug Ganetespib May Help Fight Certain Advanced Lung Cancers


ganetespib

STA 9090, cas no 888216-25-9

read all at

http://www.drugs.com/news/new-may-help-fight-certain-advanced-lung-cancers-44819.html

 

by

WORLD DRUG TRACKER

DR ANTHONY CRATO

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ORGANIC SPECTROSCOPY

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 

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I , Dr A.M.Crasto is writing this blog to share the knowledge/views, after reading Scientific Journals/Articles/News Articles/Wikipedia. My views/comments are based on the results /conclusions by the authors(researchers). I do mention either the link or reference of the article(s) in my blog and hope those interested can read for details. I am briefly summarising the remarks or conclusions of the authors (researchers). If one believe that their intellectual property right /copyright is infringed by any content on this blog, please contact or leave message at below email address amcrasto@gmail.com. It will be removed ASAP