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ORGANIC SPECTROSCOPY

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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FDA May 2014 Products Receiving Orphan Designation


Orphan Druganaut Blog's avatarOrphan Druganaut Blog

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The chart below identifies FDA May 2014 Products Receiving Orphan Designation as of 05/31/14 in ascending “Orphan Drug Designation Date” order.

FDA May 2014 Products Receiving Orphan Designation 

#Generic Name/ODD DateSponsor CompanyIndication
1Filanesib/ 05.06Array BioPharmaMultiple Myeloma
2Autologous dendritic cells pulsed with allogeneic tumor cell lysate/ 05.06Amphera BV (Netherlands)Malignant Mesothelioma
3Ex vivo cultured human mesenchymal stromal cells / 05.08iCell Science AB (Sweden)Prevention of graft rejection following solid organ transplantation
4Adalimumab/ 05.13AbbVieUveitis
5Diazoxide choline / 05.13EssentialisPrader-Willi Syndrome
6Vasoactive intestinal peptide (VIP)-elastin-like peptide (ELP) fusion protein / 05.13PhaseBio PharmaceuticalsPulmonary arterial hypertension
7(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N-(pyrazin-2-yl)acrylohydrazide / 05.14Karyopharm TherapeuticsDiffuse large B-cell lymphoma
8177Lu-tetraxetan-tetulomab / 05.14Nordic Nanovector AS (Norway)Follicular Lymphoma
9Selinexor; (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N-(pyrazin-2-yl)acrylohydrazide / 05.14Karyopharm TherapeuticsAcute myeloid leukemia
10Menadione Sodium Bisulfite/ 05.14

View original post 198 more words

Cocrystals


Abstract Image

 

Active pharmaceutical ingredients (APIs) are frequently delivered to the patient in the solid state as part of such dosage forms as tablets, capsules, etc.In this context the ability to deliver the drug to the patient in a safe, efficacious and cost-effective way depends largely on the physicochemical properties of the APIs in the solid state, and ……..read more

http://www.allfordrugs.com/cocrystals/

API SCALEUP (R AND D)


The ultimate goal of drug synthesis is to scale up from producing milligram quantities in a laboratory to producing kilogram to ton quantities in a plant, all while maintaining

all at

http://www.allfordrugs.com/api-scaleup-r-and-d/

Polymer Nanoflower Encapsulates Two Cancer Drugs to Hit Tumors with More Punch


Lyranara.me's avatarLyra Nara Blog

Many existing anti-cancer drugs can be disappointingly ineffective in clinical practice, but often it is the delivery method and not the medication itself that limits effectiveness. Being able to deliver multiple drugs together, each with a different mechanism of action, to their target can be considerably more powerful than separate administrations. Researchers at North Carolina State University and the University of North Carolina at Chapel Hill have developed a “nanoflower” made out of a hydrophilic polymer that carries camptothecin and doxorubicin directly into cancer cells.

nanoflower Polymer Nanoflower Encapsulates Two Cancer Drugs to Hit Tumors with More Punch

The hydrophobic drugs are encapsulated within the polyethylene glycol structure similarly to how proteins fold in on themselves. At about 50 nanometers in diameter, the nanoflowers can be injected into the bloodstream to seek out cancer cells. In an animal study, the structures stayed together until they penetrated lung cancer cells by taking advantage of “lipid raft and clathrin-mediated endocytotic pathway without premature leakage,” according…

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आयुर्वेद न्यूट्रास्यूटीकल्स ; अधिक गर्मी के कारण होने वाली तकलीफो से बचने के लिये ………


Dr.D.B.Bajpai's avatar**आधुनिक युग आयुर्वेद ** ई०टी०जी० आयुर्वेदास्कैन ** DIGITAL AYURVEDA TRIDOSHO SCANNER**AYURVED H. T. L. WHOLE-BODY SCANNER**आयुषव्यूज रक्त केमिकल केमेस्ट्री परीक्षण अनालाइजर ** डिजिटल हैनीमेनियन होम्योपैथी स्कैनर **

आयुर्वेद की विशेषता यही है कि सभी मौसम के लिये सभी के लिये आयुर्वेद के मनीषियों ने मौसम से प्राप्त सभी वस्तुओ के सटीक उपयोग के लिये combinations  दे दिये है /

गर्मी के मौसम मे गर्म हवाओ के चलने और लू लपट high degree temperature के चलते हुये बहुत सी तकलीफे शरीर मे अचानक पैदा होने की स्तिथि बन जाती है , इन सभी अवस्थाओ से बचने के लिये नीचे लिखे nueutraceutical   को अपनाइये और फायदा उठाइये ;

साम्ग्री सब आप्के किचन मे मिल जायेगी /

१- एक छोटा प्याज , बड़ा हो तो आधा कर ले

२- एक कच्चा छोटा आम / अमिया

३-१५ -२० पुदीना की पत्ती / अधिक भी छोड़ सकते है

४- एक टुकड़ा अदरख

५- एक चम्मच जल जीरा मसाला पाउडर

५- आधा चम्मच काली मिर्च

६- स्वादानुसार काला नमक

७- एक या दो चम्मच शक्कर  / चीनी  / गुड़

८- आधा या…

View original post 277 more words

Study shows oxytocin hormone enhances placebo response in analgesia model


Dolutegravir in HIV-1 infection: Added benefit in adult patients — ScienceDaily


FDA approves STELARA (Ustekinumab) for treatment of active psoriatic arthritis


Researchers uncover potential vaccine that can stop malaria parasites from multiplying


Late-stage fluorination, what do you think ?


developingtheprocess's avatarDeveloping the Process

Hi Everyone,  I have really been appreciating the visits to my blog.  I had resurrected this dormant site blog a while ago and hoped I could get a fair number of visits.   I have been overwhelmed with the response.  Some of the posts were clear winners, like the Revlimid case, for sure.  I, recently, came across this review in Organic Process Research & Development and realized there probably would be two sides to this argument.

Late-stage fluorination.  The current review in OPRD can be found at Michael G. Campbell and Tobias Ritter*, “Late-Stage Fluorination: From Fundamentals to Application”, Org. Process Res. Dev. 2014, 18, 474−480

doi: 10.1021/op400349g  

I remember, many years ago, discussing this with a colleague about adding a fluorine group to a molecule.  We both agreed that it would be far better to add a fluorine early on the synthesis, so if there were side-products, you would…

View original post 315 more words