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This shows untreated cancer keratonicytes. Image: Queen Mary, University of London

London, UK (Scicasts) – Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early and late-stage oral and skin cancers, according to new research from scientists at Queen Mary, University of London.

In vitro tests showed omega-3 fatty acids induced cell death in malignant and pre-malignant cells at doses which did not affect normal cells, suggesting they have the potential to be used in both the treatment and prevention of certain skin and oral cancers. Omega-3 polyunsaturated fatty acids cannot be made by humans in large quantities and so we must acquire them from our diet.

http://scicasts.com/cancer-research/6382-research-suggests-fatty-acids-could-aid-cancer-prevention-and-treatment

Antiviral patents released by Roche

August 7, 2013 7:52 am / 4 Comments on Antiviral patents released by Roche

READ ALL AT

http://www.allfordrugs.com/2013/08/07/antiviral-patents-released-by-roche/

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August 7, 2013 7:50 am / Leave a comment

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http://www.allfordrugs.com/2013/08/07/azathioprine/

Onion: Health Benefits and Medical Uses ( acts as blood thinner)

August 6, 2013 2:56 pm / Leave a comment

Onion is a commonly known plant. The part used is the bulb, which grows underground. It is an essential part of our kitchen herbs and spices. Onion is used in lots of recipes all over the world particularly in South Asia. It is both herb and vegetable used in all seasons. It has been part of many herbal preparations particularly sexual medicines since ages due to its medical properties. Apart from the chemistry of onion, it has dry-warm characteristics, which are used to treat various ailments. It is a boon for those having wet-cold constitutions. Many diseases associated with wet-cold group can be treated with onion. In homeopathy it comes under the name Allium Cepa and is used for a multitude of symptoms. Following are some of the common uses: –

Asthma
Cholera
It is an excellent first aid for cholera. In most cases, a teaspoonful of onion juice can give immediate relief.
Diabetes Mellitus
Very useful in lowering the level of blood sugar.

– See more at:

http://www.homeopathy.com.pk/kitchen-herbs/onion-health-benefits-medical-uses.php

http://www.homeopathy.com.pk/kitchen-herbs/onion-health-benefits-medical-uses.php#sthash.vmiEqWJl.dpuf

webmd info

Onion is a plant. The bulb (rounded underground part) of the onion is used to make medicine.

Onion is used for treating digestion problems including loss of appetite, upsetstomach, and gallbladder disorders; for treating heart and blood vessel problems including chest pain (angina) and high blood pressure; and for preventing “hardening of the arteries” (atherosclerosis). It is also used for treating sore mouth and throat,whooping cough, bronchitis, asthma, dehydration, intestinal gas, parasitic worms, and diabetes. Some people use it as a diuretic to increase urine output.

Onion is applied directly to the skin for insect bites, wounds, light burns, boils, warts, and bruises.

In foods, onion is used in many recipes.

In manufacturing, the oil is used to flavor foods.

How does it work?

Onion might help reduce cholesterol levels, a risk factor for hardening of the arteries. There is some evidence that onion might also reduce lung tightness in people with asthma.

MEDICINAL QUALITIES OF ONION

Research shows that onions may help guard against many chronic diseases. That’s probably because onions contain generous amounts of the flavonoid quercetin. Studies have shown that quercetin protects against cataracts, cardiovascular disease, and cancer. In addition, onions contain a variety of other naturally occurring chemicals known as organosulfur com-pounds that have been linked to lowering blood pressure and cholesterol levels.7Onions contain 25 active compounds that appear to inhibit the growth of cancerous cells alliin being the main constituent. Onion has been found to help combat heart disease, inhibit strokes, lower blood pressure and cholesterol, and stimulate the immune system. The potassium salts and the flavonoides that are present perform an anti-inflammatory action. The essential oil is an expectorant, antiseptic, antifungal, anticoagulant, high-blood pressure, antithelmitic, balsamic, rubefciant, and has analgesic properties

In investigating the use of onion in medicinal terms, the onion is found to be a remedy for conditions with symptoms like those which are caused by exposure to onions, such as watering eyes, and a burning and running nose. When looking at the symptoms of cold, it is ironic that we would treat this ailment with an almost like-with-like therapy. Alliums are antibacterial and anti-fungal, so they can help ward off colds and treat colds with sinus congestion that shifts from side to side in the head. Onion will relieve coughs that cause a ripping or tearing pain in the throat or a cough that is merely an irritating dry tickle. The watery and inflamed eyes due to sinus con-gestion and hay fever will be greatly relieved with onion.

The onions ability to relieve congestions especially in the lungs and bronchial tract, is hard to believe until you have actually witnessed the results. The drawing of infection, congestion and colds out of the ear is also remarkable.

The onion will relieve stomach upset and other gastrointestinal disorders and it will also strengthen the appetite.

Onions help prevent thrombosis and reduce hypertension, according to the American Heart Association. 8 The natural constituents of yellow or white onions can “…raise HDL cholesterol by 30% over time”, according to Dr. Victor Gurewich of Tufts University.9

The onion is being used for compresses to be applied to the skin for acne, arthritis, and congestion, and used internally for worms. The onion is also known for its diuretic properties.

There have been cases in which the onion has been proven to be so effective as an antiviral that a cut piece of onion placed in a closed off room will prevent the person in the room to be safe from viruses.

Onion will relieve headache centered behind the forehead; earache in children and adults; stuffed up nose with discharge that makes nostrils and upper lip sore or stuffed up nose with discharge from the alternate nostril; toothache, especially in the molar area or the shifting from side to side or from one tooth to another; hoarseness and the early stages of laryngitis; abdominal colic in babies.

Keeping cooler rooms in the home, and getting plenty of fresh air may prevent the symptoms of a stuffy nose and hoarseness

Never mind the tears they bring on—onions are an ace ally in your fight against disease. A prized member of the lily family, they lavish you with health benefits while adding oodles of taste to your food.

A quick glimpse at their incredible health benefits:

The phytochemicals in onions improve the working of Vitamin C in the body, thus gifting you with improved immunity.
Onions contain chromium, which assists in regulating blood sugar.
For centuries, onions have been used to reduce inflammation and heal infections.
Do you enjoy sliced onions with your food? If yes, rejoice! Raw onion encourages the production of good cholesterol (HDL), thus keeping your heart healthy.
A powerful compound called quercetin in onions is known to play a significant role in preventing cancer.
Got bitten by a honeybee? Apply onion juice on the area for immediate relief from the pain and burning sensation.
Onions scavenge free radicals, thereby reducing your risk of developing gastric ulcers.
Those bright green tops of green onions are rich in Vitamin A, so do use them often.

My favorite way to enjoy onions is to slice them really thin, squeeze some lemon juice on top and add a little salt. Sprinkling a few freshly washed cilantro leaves adds fragrance and flavor to this simple, quick salad, without which no dinner of mine is complete.

Onion cells from tammi-1990

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Yusuf Hamied – Cipla

August 6, 2013 3:58 am / Leave a comment

Name: Yusuf Hamied

Title: Chairman and Managing Director, Cipla

http://www.fiercebiotech.com/special-reports/yusuf-hamied-cipla

Yusuf Hamied made his name a decade ago when he faced down Big Pharma on patents for HIV/AIDS drugs and Cipla started selling them at a cost of about $1 a day. His disdain for what he considers Big Pharma’s “obscene prices” born out of monopolies is well documented. Hamied has the industry’s rapt attention again with his new attack on cancer meds and his avowal that Cipla will soon take on biologics.

Yusuf Khwaja Hamied is a leading Indian scientist and chairman of Cipla, a socially conscious generic pharmaceuticals company founded by his father Khwaja Abdul Hamiedin 1935.^[2]

Born in Vilnius, Lithuania, Yusuf Hamied was raised in Bombay (now known as Mumbai). His Indian Muslim father and Russophone Jewish mother met in Berlin, where they both were graduate students. He holds a Ph.D. in chemistry from Christ’s College, Cambridge. He still uses his chemistry notebooks from Cambridge when he develops new syntheses of drugs.^[3]

He is an alumnus of the Cathedral and John Connon School in Bombay. Affectionately called Yuku by his close friends, Hamied is fond of Western classical music and has been close friends with the world-famous conductor Zubin Mehta since boyhood.

Hamied is best known outside India for defying large Western pharmaceutical companies in order to provide generic AIDS drugs and treatments for other ailments primarily affecting people in poor countries. He was awarded the Padma Bhushan by the Government of India in 2005.

Hamied has led efforts to eradicate AIDS in the developing world and to give patients life-saving medicines regardless of their ability to pay,^[4] and has often been characterized as a modern-day Robin Hood figure^[5]^[6]^[7]^[8] as a result.

Former head of Johnson and Johnson Ajit Dangi says plainly “In Africa, Cipla is a temple and Dr. Hamied is God.” ^[9] To this Hamied has countered “I don’t want to make money off these diseases which cause the whole fabric of society to crumble”. ^[10]

In September 2011, in a piece about how he was trying to radically lower costs of biotech drugs for cancer, diabetes and othernoncommunicable diseases, The New York Times wrote of Hamied:

Dr. Yusuf K. Hamied, chairman of the Indian drug giant Cipla Ltd., electrified the global health community a decade ago when he said he could produce cocktails of AIDS medicines for $1 per day — a fraction of the price charged by branded pharmaceutical companies. That price has since fallen to 20 cents per day, and more than six million people in the developing world now receive treatment, up from little more than 2,000 in 2001.^[11]

Yusuf Hamied has also been enormously influential in pioneering development of multi-drug combination pills (also known as fixed-dose combinations, or FDCs), notably for HIV/AIDS, tuberculosis (TB), asthma and other ailments chiefly affecting developing countries, as well as development of pediatric formulations of drugs, especially those benefiting children in poor settings.^[12] These innovations have greatly expanded access to medicine and increased drug safety by ensuring proper dosages are taken. He is also highly regarded for his leading role in expanding the production of bulk drugs and “active pharmaceutical ingredients” (APIs, the active chemical components in medicines) in India.^[13]

In 2009 the Yusuf Hamied Centre was opened at Christ’s College, Cambridge.^[1]^[14]

Yusuf Hamied has been the subject of in-depth profiles in The New York Times, Time magazine, The Guardian, Le Monde, The Economist, the Financial Times, The Times (London), Corriere della Sera, Der Spiegel, Wired and numerous other leading publications, as well as on television outlets such as ABC News, the BBC, CNN and CBS’ 60 Minutes.

Yusuf Hamied was awarded the ‘Indian Of The Year’ in the category of business by CNN-IBN in 2012.^[15]

“Christ’s officially opens Yusuf Hamied Centre”. University of Cambridge News. 2009-04-20. Retrieved 2009-04-20.
Sarah Boseley (2003-02-18). “Yusuf Hamied, generic drugs boss | World news”. London: The Guardian. Retrieved 2010-09-01.
Selling Cheap ‘Generic’ Drugs, India’s Copycats Irk Industry, By DONALD G. McNEIL Jr, Published: December 01, 2000
“Interview of the week: Yusuf Hamied. – United Press International | HighBeam Research – FREE trial”. Highbeam.com. 2001-02-22. Retrieved 2010-09-01.
“[Esplora il significato del termine: Yusuf Hamied, un Robin Hood contro l’ Aids “Così sconfiggerò l’ Aids senza le multinazionali”] Yusuf Hamied, un Robin Hood contro l’ Aids “Così sconfiggerò l’ Aids senza le multinazionali””.
Bobin, Frédéric (2010-07-06). “India fears generic drugs for poor are endangered by proposed EU trade deal”. The Guardian(London).
“Dr. Hamied Robin Hood spoof film posters”.
“Robin Hood and the Multinationals”.
Hans Lofgren, The Politics of the Pharmaceutical Industry and Access to Medicine, 2012, p. 55
Hans Lofgren, The Politics of the Pharmaceutical Industry and Access to Medicine, 2012, p. 68
Harris, Gardiner (2011-09-18). “China and India Making Inroads in Biotech Drugs”. The New York Times.
Hans Lofgren, The Politics of the Pharmaceutical Industry and Access to Medicine, 2012, p. 58-59
Hans Lofgren, The Politics of the Pharmaceutical Industry and Access to Medicine, 2012, p. 63
“The Hindu News Update Service”. Chennai, India: Hindu.com. 2009-04-22. Retrieved 2010-09-01.
http://ibnlive.in.com/news/dr-yusuf-hamied-message-on-being-cnnibns-indian-of-the-year-2012-in-the-business-category/310908-3.html.

Sanofi Pasteur Initiates Phase III Study of Investigational Clostridium difficile Vaccine in the United States

August 6, 2013 1:00 am / 2 Comments on Sanofi Pasteur Initiates Phase III Study of Investigational Clostridium difficile Vaccine in the United States

Cdiffense trial to evaluate vaccine against a leading cause of life-threatening, healthcare-associated infections worldwide

SWIFTWATER, Pa., Aug. 5, 2013 /PRNewswire/ — Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: SAN and NYSE: SNY), announced today the initiation of its Phase III clinical program called Cdiffense to evaluate the safety, immunogenicity and efficacy of an investigational vaccine for the prevention of primary symptomatic Clostridium difficile infection (CDI). Clostridium difficile (C. diff) is a potentially life-threatening, spore-forming bacterium that causes intestinal disease. The risk of C. diff increases with age, antibiotic treatment and time spent in hospitals or nursing homes, where multiple cases can lead to outbreaks. The investigational vaccine is designed to help protect at-risk individuals from C. diff, which is emerging as a leading cause of life-threatening, healthcare-associated infections (HAIs)worldwide, read all at…………….

http://www.pharmalive.com/sanofi-starts-phase-iii-trial-for-clostridium-difficile-vaccine

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New Findings Could Influence Development of Therapies to Treat Dengue Disease

August 5, 2013 3:02 pm / 1 Comment on New Findings Could Influence Development of Therapies to Treat Dengue Disease

Bristol, UK (Scicasts) – New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.

The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry August 2 show that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.

read all at scicasts

http://scicasts.com/proteomics/2043-protein-functions/6391-new-findings-could-influence-development-of-therapies-to-treat-dengue-disease

Dengue from Siddharth Goyal

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Dengue Fever Power Point from orlandito12

The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight

August 5, 2013 7:00 am / 56 Comments on The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight


Kokum fruits, seeds, pulp and rinds.jpg

The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight. The Department of Physiology researchers at the Georgetown University Medical Center in Washington DC, called Vrikshamla a safe, natural supplement for normal weight support. In an eight-week study of 60 volunteers, they reported Vrikshamla’s effectiveness in supporting normal weight, cholesterol, triglyceride and serum lipid levels.

hydroxycitric acid (HCA)

Vrikshamla grows in India the evergreen forests of the Western Ghats, the Southern Konkan region and in Goa. It is also cultivated in the Southern districts of Maharashtra and on the lower slopes of the Nilgiris mountains.

Active constituents:

The active constituent in this herb, HCA, helps weight loss by promoting normal appetite levels and by reducing the body’s ability to form adipose (fatty) tissue. HCA also reduces blood lipid levels and naturally lowers cholesterol. Other useful phytochemicals in Vrikshamla are garcinol, isogarcinol, xanthochymol and isoxanthochymol.

Herb Functions:

Weight management: The herb known to slow down the body’s ability to store fat, potentially enabling more fat from foods to pass through the body without being stored. Additionally, HCA blocks the production and storage of fat and cholesterol when calorie consumption exceeds healthy levels. The herb is also known to reduce blood lipid levels and to naturally lower cholesterol.

read at

http://www.himalayahealthcare.com/products/pharmaceuticals/vrikshamla.htm

Garcinia indica, a plant in the mangosteen family (Clusiaceae), commonly known askokum, punar puli (tulu language), is a fruit-bearing tree that has culinary, pharmaceutical, and industrial uses.

The genus Garcinia, belonging to the family Clusiaceae, includes about 200 species found in the Old World tropics, mostly in Asia and Africa. Garcinia indica is indigenous to theWestern Ghats region of India located along the western coast of the country. Of the 35 species found in India, 17 are endemic. Of these, seven are endemic to the Western Ghats, six in the Andaman and Nicobar Islands and four in the northeastern region of India.

Garcinia indica is found in forest lands, riversides and wastelands. These plants preferevergreen forests, but sometimes they also thrive in areas with relatively low rainfall. It is also cultivated on a small scale. It does not require irrigation, spraying of pesticides or fertilizers.

Garcinia indica is known by various names across India, including aamsol, aamsul, bindin, biran, bhirand,bhrinda, brinda, bin’na, kokum (alternate spellings kokam and cocum), katambi, looikya, sour apple, panarpuli, ratamba, thekera (in Assam) and many others.

The dried skin of kokum fruits

The outer cover of fruit is dried in the sun to get aamsul or kokam. It is used as a slightly sour spice in recipes from Maharashtra. Kokum yields a peculiar flavour and blackish red colour. It is a preferred substitute for tamarind in curries and other dishes from the Konkanregion. It is also used in cuisine from Gujarat, where it is frequently used to add flavor and tartness to dal (lentil soup) for flavor balance, and parts of South India.

The vessel on the left contains syrup which is obtained from the vessel containing kokum rinds, on the right. The syrup is used to make kokum sherbet

Kokum squash or kokum concentrate is used in preparing a drink (sherbet) which is bright red in colour. Kokum sherbet improves digestion and cools the body during summers^{[citation needed]}.

Further, the extract/ concentrate of this fruit is called aagal in Konkani and Marathi. It is to added during the preparation of solkadhi, along with coconut milk.

Industrial uses

The seed of Garcinia indica contains 23–26% oil, which remains solid at room temperature. It is used in the preparation of confectionery, medicines and cosmetics.

Recently, industries have started extracting hydroxycitric acid (HCA) from the rind of the fruit.^{[citation needed]}

The tree is ornamental, with a dense canopy of green leaves and red-tinged, tender, young leaves. The oily extract called kokum tel is used in foot massage.

Vivimed Acquires A US FDA Approved Formulation Manufacturing Facility

August 5, 2013 5:06 am / 1 Comment on Vivimed Acquires A US FDA Approved Formulation Manufacturing Facility

Managing Director and CEO Santosh Varalwar, vivimed labs ltd

Vivimed Labs Ltd, established in 1989, is a diversified global company with a unique portfolio of products in Specialty Chemicals and Pharmaceuticals. Vivimed has gradually increased its portfolio of offerings through product innovations at its Research & Development Center. Some of its reputed clientele includes Unilever, P&G, L’Oreal, ISP, Novartis, Merck, Cipla, Astra Zeneca, BDF, AVON and others. The Product offerings comprises Hair care, Skincare, Oral Care, Antimicrobials & Preservatives, Photo Imaging Chemicals & Photo Chromic, Specialized Formulations such as Opthalamic, Anti Ulcer, Antehelminth and other health care segments

1 aug 2013

Vivimed Labs Ltd., manufacturer of specialty chemicals and pharmaceuticals, announced the signing of an agreement to acquire Actavis Pharma Manufacturing Pvt. Ltd.’s solid oral dosage facility in Alathur in Tamil Nadu for an aggregate consideration of Rs.122 crore.

The facility is being acquired from its parent Actavis Holding Asia B.V., an affiliate of Actavis Inc., a leading global general and specialty pharmaceutical company.

read at

http://pharmadeals.pharmaintellect.com/2013/08/vivimed-acquires-us-fda-approved.html?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+Pharmainvest+%28PharmaInvest%29

Flow synthesis for Novartis anticancer drug, Gleevec, Imatinib

August 5, 2013 4:24 am / 4 Comments on Flow synthesis for Novartis anticancer drug, Gleevec, Imatinib

The flow-based route required minimal manual intervention and was achieved despite poor solubility of many reaction components

21 January 2013Michael Parkin

http://www.rsc.org/chemistryworld/2013/01/flow-synthesis-anticancer-drug

UK chemists have used a combination of flow chemistry methods with solid-supported scavengers and reagents to synthesise the active pharmaceutical ingredient, imatinib, of the anticancer drug Gleevec. The method avoids the need for any manual handling of intermediates and allows the drug to be synthesised in high purity in less than a day.

Gleevec, developed by Novartis, is a tyrosine kinase inhibitor used for the treatment of chronic myeloid leukaemia and gastrointestinal stromal tumours.

READ ALL AT

http://www.rsc.org/chemistryworld/2013/01/flow-synthesis-anticancer-drug



IMATINIB

CREDIT

http://www.veomed.com/va041542042010

‘Wrapping’ Gleevec Fights Drug-Resistant Cancer, Study Shows

http://www.sciencedaily.com/releases/2007/05/070501115127.htm

The anti-cancer drug Gleevec® is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area. This image shows the bandage (black box) on the modified version of the drug, WBZ-7. (Credit: Image courtesy of Rice University)

A new study in Cancer Research finds that the anti-cancer drug Gleevec® is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area.

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Research Suggests Fatty Acids Could Aid Cancer Prevention and Treatment

Antiviral patents released by Roche

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