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DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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Ixchelsis, a start-up company that has come out of Pfizer’s former R D site at Sandwich, UK, is progressing a treatment for premature ejaculation boosted by the backing of Eli Lilly.
Lilly, through its venture fund set up with TVM Capital Life Science, has
invested in Ixchelsis, made up of former Pfizer scientists and headed by Gary
Muirhead. The company is based on an oxytocin receptor antagonist called IX-01
originally discovered at Sandwich which the investors say “has the potential to
be the best-in-class pharmacological approach for the treatment of
PE”.
Ixchelsis, which is based at the Sandwich site, now called Discovery
Park, will collaborate with the autonomous early phase virtual drug discovery
arm of Lilly, known as Chorus. Dr Muirhead told PharmaTimes that the
TVM model will fund through to the agreed exit point, which is completion of
proof-of-concept and this requires about $14 million.
read all at
http://www.pharmatimes.com/Article/13-08-08/Lilly_backs_Ixchelsis_a_start-up_born_at_Pfizer.aspx
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Cancer
Cancer is a broad group of various diseases involving unregulated cell growth. It is medically known as a malignant neoplasm. In cancer, cells divide and grow uncontrollably and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream, it is called metastasis. However, not all tumors are cancerous. Some tumors do not grow uncontrollably, do not invade neighboring tissues, and do not spread throughout the body which are called Benign tumors.
There are more than 100 types of Cancers. Follow the link to know more:
http://www.cancer.gov/cancertopics/types/alphalist
Classification of Cancers:
There are five broad groups that are used to classify cancer.
- Carcinomas: These are characterized by cells that cover internal and external parts of the body such as lung, breast, and colon cancer.
- Sarcomas:These are characterized by cells that are…
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दुबलापन यानी दुबला शरीर या शरीर ऐसा जो हड्डियों का ढान्चा जैसा हो ; single chasis body ; very slim body ; skeleton body
दुबले आदमियों या दुबले लडकों या दुबली लड़्कियों या दुबली महिलाओं को आपने देखा होगा, कैसे लगते हैं देखने में ?
दुबले शरीर का होना अछ्छी बात है , एकहरा बदन हो तो यह बहुत अच्छा लगता है , फिल्मों के हीरो हीरोइनों को देखिये कोई भी आपको बहुत मोटा नही दिखाई देगा , सब इसीलिये अपने को maintain किये रहते हैं, किसलिये ?
आखिर छरहरा बदन भी कोई चीज होती है ? यही छरहरा बदन सब्को देखने मे अच्छा लगता है /
लेकिन अगर शरीर जरूरत से ज्यादा दुबला हो, skeleton जैसा दिखाई दे, तो फिर यह देखने वालों को अच्छा नही लगता /
आयुर्वेद में दुबले पतले लोगों के लिये महर्षि चरक ने लिखा है कि ” रूखा सूखा अन्न खाने वाले, अत्यधिक लन्घन यानी खाना या भोजन न खाने वाले, कम भोजन करने वाले, अधिक मेहनत करने वाले और कम खाना खाने वाले, ज्यादा जुलाब या enema…
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The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight
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| Kokum fruits, seeds, pulp and rinds.jpg |
The rind of the Vrikshamla (Garcinia/Garcinia indica) fruit contains an active component called hydroxycitric acid (HCA), which supports normal fat and carbohydrate metabolism, a healthy appetite level and optimum body weight. The Department of Physiology researchers at the Georgetown University Medical Center in Washington DC, called Vrikshamla a safe, natural supplement for normal weight support. In an eight-week study of 60 volunteers, they reported Vrikshamla’s effectiveness in supporting normal weight, cholesterol, triglyceride and serum lipid levels.
hydroxycitric acid (HCA)
Vrikshamla grows in India the evergreen forests of the Western Ghats, the Southern Konkan region and in Goa. It is also cultivated in the Southern districts of Maharashtra and on the lower slopes of the Nilgiris mountains.
Active constituents:
The active constituent in this herb, HCA, helps weight loss by promoting normal appetite levels and by reducing the body’s ability to form adipose (fatty) tissue. HCA also reduces blood lipid levels and naturally lowers cholesterol. Other useful phytochemicals in Vrikshamla are garcinol, isogarcinol, xanthochymol and isoxanthochymol.
Herb Functions:
Weight management: The herb known to slow down the body’s ability to store fat, potentially enabling more fat from foods to pass through the body without being stored. Additionally, HCA blocks the production and storage of fat and cholesterol when calorie consumption exceeds healthy levels. The herb is also known to reduce blood lipid levels and to naturally lower cholesterol.
read at
http://www.himalayahealthcare.com/products/pharmaceuticals/vrikshamla.htm
Garcinia indica, a plant in the mangosteen family (Clusiaceae), commonly known askokum, punar puli (tulu language), is a fruit-bearing tree that has culinary, pharmaceutical, and industrial uses.
The genus Garcinia, belonging to the family Clusiaceae, includes about 200 species found in the Old World tropics, mostly in Asia and Africa. Garcinia indica is indigenous to theWestern Ghats region of India located along the western coast of the country. Of the 35 species found in India, 17 are endemic. Of these, seven are endemic to the Western Ghats, six in the Andaman and Nicobar Islands and four in the northeastern region of India.
Garcinia indica is found in forest lands, riversides and wastelands. These plants preferevergreen forests, but sometimes they also thrive in areas with relatively low rainfall. It is also cultivated on a small scale. It does not require irrigation, spraying of pesticides or fertilizers.
Garcinia indica is known by various names across India, including aamsol, aamsul, bindin, biran, bhirand,bhrinda, brinda, bin’na, kokum (alternate spellings kokam and cocum), katambi, looikya, sour apple, panarpuli, ratamba, thekera (in Assam) and many others.
The dried skin of kokum fruits
The outer cover of fruit is dried in the sun to get aamsul or kokam. It is used as a slightly sour spice in recipes from Maharashtra. Kokum yields a peculiar flavour and blackish red colour. It is a preferred substitute for tamarind in curries and other dishes from the Konkanregion. It is also used in cuisine from Gujarat, where it is frequently used to add flavor and tartness to dal (lentil soup) for flavor balance, and parts of South India.
The vessel on the left contains syrup which is obtained from the vessel containing kokum rinds, on the right. The syrup is used to make kokum sherbet
Kokum squash or kokum concentrate is used in preparing a drink (sherbet) which is bright red in colour. Kokum sherbet improves digestion and cools the body during summers[citation needed].
Further, the extract/ concentrate of this fruit is called aagal in Konkani and Marathi. It is to added during the preparation of solkadhi, along with coconut milk.
Industrial uses
The seed of Garcinia indica contains 23–26% oil, which remains solid at room temperature. It is used in the preparation of confectionery, medicines and cosmetics.
Recently, industries have started extracting hydroxycitric acid (HCA) from the rind of the fruit.[citation needed]
The tree is ornamental, with a dense canopy of green leaves and red-tinged, tender, young leaves. The oily extract called kokum tel is used in foot massage.
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