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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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Colfosceril miristate


Colfosceril miristate

CAS 18194-24-6

MF C36H72NO8P MW677.9325

1,2 Dimyristoyl glycero 3 phosphorylcholine

(2R)-2,3-bis(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
surfactant replacement, DIMYRISTOYL LECITHIN, Dimyristoyllecithin, DMCP, DMPC

Colfosceril miristate (1,2-dimyristoyl-sn-glycero-3-phosphocholine or DMPC) is a synthetic phospholipid commonly used in research to study lipid bilayers, liposomes, and drug delivery systems. It serves as a model membrane system due to its phase transition properties and has shown potential in enhancing nanoparticle uptake and acting as a drug stabilizer. 

Key Aspects of Colfosceril Miristate (DMPC):

  • Scientific Application: Primarily used in laboratory research for studying lipid monolayers and bilayers.
  • Drug Delivery: Employed in the creation of liposomes for drug delivery applications.
  • Biological Activity: Exhibits antiproliferative effects on various tumor cell lines and can increase the cellular uptake of nanoparticles.
  • Characteristics: It is a synthetic phospholipid, frequently studied for its phase transition temperature (approx. ).
  • Storage: Should be stored at  or  to maintain stability. 

Important Distinction:
It is crucial not to confuse Colfosceril miristate (DMPC) with Colfosceril palmitate (DPPC). Colfosceril palmitate is a different synthetic surfactant historically used in medicine to treat neonatal respiratory distress syndrome

1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (dimyristoyl phosphatidylcholine, DMPC) is a synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. DMPC is a frequently studied artificial lipid because it undergoes a phase transition at a convenient temperature. Upon cooling below 23.6°C it undergoes a transition from the liquid crystalline phase to the solid rippled phase, characterized by periodic corrugations of the bilayer.

Dimyristoylphosphatidylcholine is a phosphatidylcholine, a kind of phospholipid. Along with other lipids, it can be used to prepare liposomes.[1]

PAT

US5798091

PAT

Compositions of Phosphorylated Tau Peptides and Uses Thereof

Publication Number: US-2025326806-A1

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Names
Systematic IUPAC name(2R)-2,3-Bis(tetradecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
Other names1,2-dimyristoylphosphatidylcholine, 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine, DMPC, 14:0 PC
Identifiers
CAS Number18194-24-6
3D model (JSmol)Interactive image
ChEBICHEBI:45240
ChEMBLChEMBL1235508
ChemSpider4573168
ECHA InfoCard100.038.245 
EC Number242-085-9
PubChem CID5459377
UNII52QK2NZ2T0
CompTox Dashboard (EPA)DTXSID00860227 
InChI
SMILES
Properties
Chemical formulaC36H72NO8P
Molar mass677.945 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).Infobox references

References

  1.  Liposomal drug delivery system from laboratory to clinic, N. A. Kshirsagar, S. K. Pandya, G. B. Kirodian, S. Sanath, Journal of Postgraduate Medicine51 (#5) (2005), pp. 5-15, PMID 16519249.

//////////colfosceril miristate, ANAX LAB, surfactant replacement, DIMYRISTOYL LECITHIN, Dimyristoyllecithin, DMCP, DMPC