Florcicaper (18F)

CAS 855927-17-2

MF C18H3318FO2, MW 299.4544

2-[(1S,2R)-2-(5-(¹⁸F)fluorotridecyl)cyclopropyl]acetic acid

2-((1S,2R)-2-(5-(FLUORO-18F)TRIDECYL)CYCLOPROPYL)ACETIC ACID

TRANS-9(RS)-18F-FLUORO-3,4(RS,RS)-METHYLENEHEPTADECANOIC ACID

rac-{(1R,2S)-2-[(5RS)-5-(18F)fluorotridecyl]cyclopropyl}aceticacid
imaging agent, CARDIOPET, (18F FCPHA), FDG79C95XB

CardioPET is: An F-18 labeled, modified fatty acid that provides insight into regions with decreased blood flow or metabolic insufficiency in the myocardium.; CardioPET may be used to: Identify patients that will benefit from PCI or revascularization and guide intervention, Assess myocardial viability, Evaluate CAD in patients that cannot exercise.; Agent: Muscle State Imaging Agent, Type: Fatty Acid (Labeled with Fluorine 18), Condition: Coronary Artery Disease, Status: completed enrollment.;This imaging agent exploits the dietary needs of the heart as it relates to glucose and fatty acids. By introducing a radio-labeled analog to the natural fatty acids utilized as an energy source by the heart we can visualize the anatomic location and state of the muscle within the areas defined by the specific coronary artery blood flow distribution and detect problems in advance of symptoms that would lead to a stress test.

Cardiopet is under investigation in clinical trial NCT01826773 (Cardiopet as PET Imaging Agent to Assess Myocardial Perfusion and Fatty Acid Uptake in Known or Suspected CAD Subjects).

A Phase I Study in Healthy Volunteers to Evaluate the Safety of CardioPET™ in Detection of Coronary Artery Disease

CTID: NCT00413647

Phase: Phase 1

Status: Completed

Date: 2013-06-12

PATENTS

CA-2876139-A1
CN-104684546-A
CN-114736112-A
CN-115141087-A
CN-115141087-B
CN-115141125-A
CN-115141125-B
CN-115181013-A
CN-115181013-B
CN-115850224-A
CN-115850224-B
CN-115959978-A
CN-115959978-B
CN-116041169-A
CN-116199658-A
CN-116217356-A
EP-2858630-A1
EP-4133284-A1
US-10533059-B2
US-11701429-B2
US-2015361110-A1
US-2017014528-A1
US-2020199249-A1
US-2020297854-A1
US-20230314449-A1
US-20230381092-A1
US-9409927-B2
WO-2013185032-A1
WO-2022082327-A1
WO-2023085674-A1
WO-2023236978-A1
WO-2023237092-A1

PAT

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013185032&_cid=P11-MPJ5UV-89230-1

PAT

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2022082327&_cid=P11-MPJ5WJ-90048-1

ADVT

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References

• Nanotherapeutics for drug targetingPublication Number: WO-2013185032-A1Priority Date: 2012-06-07
• Nanotherapeutics for drug targetingPublication Number: EP-2858630-A1Priority Date: 2012-06-07
• Super lewis acidic borate esters as 18F-labeled PET probesPublication Number: US-9409927-B2Priority Date: 2013-01-24Grant Date: 2016-08-09
• Super lewis acidic borate esters as 18f-labeled pet probesPublication Number: US-2015361110-A1Priority Date: 2013-01-24
• Nanotherapeutics for drug targetingPublication Number: CA-2876139-A1Priority Date: 2012-06-07
• Nanotherapeutics for drug targetingPublication Number: US-2020297854-A1Priority Date: 2012-06-07
• Nanotherapeutics for drug targetingPublication Number: CN-104684546-APriority Date: 2012-06-07
• Diagnosis of stage b2 dmvdPublication Number: US-2023314449-A1Priority Date: 2020-04-07
• Targeted drug delivery through affinity based linkersPublication Number: US-2017014528-A1Priority Date: 2014-03-12
• Targeted drug delivery through affinity based linkersPublication Number: US-2020199249-A1Priority Date: 2014-03-12
• Targeted drug delivery through affinity based linkersPublication Number: US-10533059-B2Priority Date: 2014-03-12Grant Date: 2020-01-14
• Targeted drug delivery through affinity based linkersPublication Number: US-11701429-B2Priority Date: 2014-03-12Grant Date: 2023-07-18

//////////florcicaper (18F), anax labs, imaging agent, CARDIOPET, (18F FCPHA), FDG79C95XB