Many existing anti-cancer drugs can be disappointingly ineffective in clinical practice, but often it is the delivery method and not the medication itself that limits effectiveness. Being able to deliver multiple drugs together, each with a different mechanism of action, to their target can be considerably more powerful than separate administrations. Researchers at North Carolina State University and the University of North Carolina at Chapel Hill have developed a “nanoflower” made out of a hydrophilic polymer that carries camptothecin and doxorubicin directly into cancer cells.

The hydrophobic drugs are encapsulated within the polyethylene glycol structure similarly to how proteins fold in on themselves. At about 50 nanometers in diameter, the nanoflowers can be injected into the bloodstream to seek out cancer cells. In an animal study, the structures stayed together until they penetrated lung cancer cells by taking advantage of “lipid raft and clathrin-mediated endocytotic pathway without premature leakage,” according…

आयुर्वेद की विशेषता यही है कि सभी मौसम के लिये सभी के लिये आयुर्वेद के मनीषियों ने मौसम से प्राप्त सभी वस्तुओ के सटीक उपयोग के लिये combinations  दे दिये है /

गर्मी के मौसम मे गर्म हवाओ के चलने और लू लपट high degree temperature के चलते हुये बहुत सी तकलीफे शरीर मे अचानक पैदा होने की स्तिथि बन जाती है , इन सभी अवस्थाओ से बचने के लिये नीचे लिखे nueutraceutical   को अपनाइये और फायदा उठाइये ;

साम्ग्री सब आप्के किचन मे मिल जायेगी /

१- एक छोटा प्याज , बड़ा हो तो आधा कर ले

२- एक कच्चा छोटा आम / अमिया

३-१५ -२० पुदीना की पत्ती / अधिक भी छोड़ सकते है

४- एक टुकड़ा अदरख

५- एक चम्मच जल जीरा मसाला पाउडर

५- आधा चम्मच काली मिर्च

६- स्वादानुसार काला नमक

७- एक या दो चम्मच शक्कर  / चीनी  / गुड़

८- आधा या…

Study shows oxytocin hormone enhances placebo response in analgesia model.

Dolutegravir in HIV-1 infection: Added benefit in adult patients — ScienceDaily.

FDA approves STELARA (Ustekinumab) for treatment of active psoriatic arthritis.

Researchers uncover potential vaccine that can stop malaria parasites from multiplying.

Hi Everyone,  I have really been appreciating the visits to my blog.  I had resurrected this dormant site blog a while ago and hoped I could get a fair number of visits.   I have been overwhelmed with the response.  Some of the posts were clear winners, like the Revlimid case, for sure.  I, recently, came across this review in Organic Process Research & Development and realized there probably would be two sides to this argument.

Late-stage fluorination.  The current review in OPRD can be found at Michael G. Campbell and Tobias Ritter*, “Late-Stage Fluorination: From Fundamentals to Application”, Org. Process Res. Dev. 2014, 18, 474−480

doi: 10.1021/op400349g  

I remember, many years ago, discussing this with a colleague about adding a fluorine group to a molecule.  We both agreed that it would be far better to add a fluorine early on the synthesis, so if there were side-products, you would…

A black and insoluble biopolymer called eumelanin and other types of melanin together determine skin and hair color, particularly for dark phenotypes. Eumelanin is also a soft, biocompatible nanomaterial with technological potential. However, previous studies of this substance have primarily been carried out with synthetic samples. In the journal Angewandte Chemie, Italian researchers have now revealed why natural eumelanin is significantly superior to the synthetic version as a radical scavenger, antioxidant, and photo-protectant.

Thanks to its unusual optoelectronic, dielectric, metal-binding, and radical-scavenging properties, eumelanin could be useful for a variety of technical applications, including organic electronic components or antioxidants for plastics. However, it was recently discovered that the properties of synthetic eumelanin are significantly different from those of the natural product.

Within pigment cells, eumelanin is produced enzymatically from tyrosine or DOPA. An important intermediate step in this process is the isomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). In…

Seeking better insight into chronic fatigue syndrome, a new brain scan investigation has pinpointed what could be the first evidence of a connection between nerve cell inflammation and the onset of this debilitating and somewhat mysterious illness, researchers say.

The finding stems from a small PET scan study, led by Yasuhito Nakatomi of the RIKEN Center for Life Science Technologies in Hyogo, Japan. The study involved just nine patients with chronic fatigue syndrome and 10 healthy participants.

However, the investigators believe that their initial results are the first to show that neuro-inflammation is a distinct feature of chronic fatigue syndrome. This inflammation affects specific areas of the brain that are commonly linked with the kind of fatigue, pain, depression, and thought-process difficulties long associated with the syndrome, the researchers noted.

“While the results will need to be confirmed in larger studies, it is a very exciting finding,” said Suzanne…