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Acefylline

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Acefylline
- Molecular FormulaC9H10N4O4
- Average mass238.200 Da
Acefylline (INN),[1] also known as acetyloxytheophylline, is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation etanautine to help offset diphenhydramine induced drowsiness.[2]
Synthesis
DE 352980 (1922 to E. Merck); Frdl. 14, 1320; S. M. Ride et al., Pharmazie 32, 672 (1977).
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Acefylline
- Use:cardiotonic, diuretic, antispasmodic, bronchodilator
- Chemical name:1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid
- Formula:C9H10N4O4
- MW:238.20 g/mol
- CAS-RN:652-37-9
- EINECS:211-490-2
- LD50:1180 mg/kg (M, i.p.); 2733 mg/kg (M, p.o.)
Acepifylline
- Use:
- Chemical name:1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid compd. with piperazine
- Formula:C9H10N4O4 • xC4H10N2
- MW:unspecified
- CAS-RN:18833-13-1
- EINECS:242-614-3
Acefylline heptaminol
- Use:
- Chemical name:1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid compd. with 6-amino-2-methyl-2-heptaminol (1:1)
- Formula:C9H10N4O3 • C8H19NO
- MW:367.45 g/mol
- CAS-RN:59989-20-7
- EINECS:262-012-4
References
- ^ “International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 21” (PDF). World Health Organization. Retrieved 29 December 2016.
- ^ Zuidema, Jan. (1978). “Biofarmaceutische en farmacokinetische aspecten van theofylline en acefylline”. Thesis (doctoral)–Universiteit van Amsterdam. References
Baisse, J.: Bull. Soc. Chim. Fr. (BSCFAS) 1949, 769.
DE 352 980 (E. Merck; 1922).
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| ECHA InfoCard | 100.010.447 |
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| Formula | C9H10N4O4 |
| Molar mass | 238.20 g/mol g·mol−1 |
| 3D model (JSmol) | |
////////Acefylline
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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