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ORGANIC SPECTROSCOPY

Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL 

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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आयुर्वेद न्यूट्रास्यूटीकल्स ; अधिक गर्मी के कारण होने वाली तकलीफो से बचने के लिये ………


Dr.D.B.Bajpai's avatar**आधुनिक युग आयुर्वेद ** ई०टी०जी० आयुर्वेदास्कैन ** DIGITAL AYURVEDA TRIDOSHO SCANNER**AYURVED H. T. L. WHOLE-BODY SCANNER**आयुषव्यूज रक्त केमिकल केमेस्ट्री परीक्षण अनालाइजर ** डिजिटल हैनीमेनियन होम्योपैथी स्कैनर **

आयुर्वेद की विशेषता यही है कि सभी मौसम के लिये सभी के लिये आयुर्वेद के मनीषियों ने मौसम से प्राप्त सभी वस्तुओ के सटीक उपयोग के लिये combinations  दे दिये है /

गर्मी के मौसम मे गर्म हवाओ के चलने और लू लपट high degree temperature के चलते हुये बहुत सी तकलीफे शरीर मे अचानक पैदा होने की स्तिथि बन जाती है , इन सभी अवस्थाओ से बचने के लिये नीचे लिखे nueutraceutical   को अपनाइये और फायदा उठाइये ;

साम्ग्री सब आप्के किचन मे मिल जायेगी /

१- एक छोटा प्याज , बड़ा हो तो आधा कर ले

२- एक कच्चा छोटा आम / अमिया

३-१५ -२० पुदीना की पत्ती / अधिक भी छोड़ सकते है

४- एक टुकड़ा अदरख

५- एक चम्मच जल जीरा मसाला पाउडर

५- आधा चम्मच काली मिर्च

६- स्वादानुसार काला नमक

७- एक या दो चम्मच शक्कर  / चीनी  / गुड़

८- आधा या…

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Study shows oxytocin hormone enhances placebo response in analgesia model


Dolutegravir in HIV-1 infection: Added benefit in adult patients — ScienceDaily


FDA approves STELARA (Ustekinumab) for treatment of active psoriatic arthritis


Researchers uncover potential vaccine that can stop malaria parasites from multiplying


Late-stage fluorination, what do you think ?


developingtheprocess's avatarDeveloping the Process

Hi Everyone,  I have really been appreciating the visits to my blog.  I had resurrected this dormant site blog a while ago and hoped I could get a fair number of visits.   I have been overwhelmed with the response.  Some of the posts were clear winners, like the Revlimid case, for sure.  I, recently, came across this review in Organic Process Research & Development and realized there probably would be two sides to this argument.

Late-stage fluorination.  The current review in OPRD can be found at Michael G. Campbell and Tobias Ritter*, “Late-Stage Fluorination: From Fundamentals to Application”, Org. Process Res. Dev. 2014, 18, 474−480

doi: 10.1021/op400349g  

I remember, many years ago, discussing this with a colleague about adding a fluorine group to a molecule.  We both agreed that it would be far better to add a fluorine early on the synthesis, so if there were side-products, you would…

View original post 315 more words

EU approves Takeda’s bowel drug Entyvio


EU approves Takeda's bowel drug Entyvio

Hot on the heels of an approval in the US, regulators in Europe have now also given Takeda’s Entyvio (vedolizumab) the nod for two inflammatory bowel diseases. The European Commission has granted Marketing Authorisation for use of the gut-selective humanised monoclonal antibody to treat adults with moderately to severely active ulcerative colitis (UC) and adults with moderately to severely active Crohn’s disease (CD).

Read more at: http://www.pharmatimes.com/Article/14-05-27/EU_approves_Takeda_s_bowel_drug_Entyvio.aspx#ixzz334DL7xQJ

Unusual structural and electronic properties make skin pigments superior radical scavengers


Lyranara.me's avatarLyra Nara Blog

Destabilization as an advantage

A black and insoluble biopolymer called eumelanin and other types of melanin together determine skin and hair color, particularly for dark phenotypes. Eumelanin is also a soft, biocompatible nanomaterial with technological potential. However, previous studies of this substance have primarily been carried out with synthetic samples. In the journal Angewandte Chemie, Italian researchers have now revealed why natural eumelanin is significantly superior to the synthetic version as a radical scavenger, antioxidant, and photo-protectant.

Thanks to its unusual optoelectronic, dielectric, metal-binding, and radical-scavenging properties, eumelanin could be useful for a variety of technical applications, including organic electronic components or antioxidants for plastics. However, it was recently discovered that the properties of synthetic eumelanin are significantly different from those of the natural product.

Within pigment cells, eumelanin is produced enzymatically from tyrosine or DOPA. An important intermediate step in this process is the isomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). In…

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Brain scans spot possible clues to chronic fatigue syndrome


Lyranara.me's avatarLyra Nara Blog

Seeking better insight into chronic fatigue syndrome, a new brain scan investigation has pinpointed what could be the first evidence of a connection between nerve cell inflammation and the onset of this debilitating and somewhat mysterious illness, researchers say.

The finding stems from a small PET scan study, led by Yasuhito Nakatomi of the RIKEN Center for Life Science Technologies in Hyogo, Japan. The study involved just nine patients with chronic fatigue syndrome and 10 healthy participants.

However, the investigators believe that their initial results are the first to show that neuro-inflammation is a distinct feature of chronic fatigue syndrome. This inflammation affects specific areas of the brain that are commonly linked with the kind of fatigue, pain, depression, and thought-process difficulties long associated with the syndrome, the researchers noted.

“While the results will need to be confirmed in larger studies, it is a very exciting finding,” said Suzanne…

View original post 563 more words

Tug Of War Over Promising Cancer Drug Candidate Drug Discovery: Structure error threatens existing patent and clinical trials


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read at

http://www.allfordrugs.com/2014/05/22/tug-of-war-over-promising-cancer-drug-candidate-drug-discovery-structure-error-threatens-existing-patent-and-clinical-trials/