WORLD RECORD VIEWS holder on THIS BLOG, ………live, by DR ANTHONY MELVIN CRASTO, Worldpeaceambassador, Worlddrugtracker, Helping millions, 100 million hits on google, pushing boundaries,2.5 lakh plus connections worldwide, 45 lakh plus VIEWS on this blog in 227 countries, 7 CONTINENTS ……A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, [THIS BLOG HOLDS WORLD RECORD VIEWS ]
DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was
with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international,
etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules
and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc
He has total of 32 International and Indian awards
This shows untreated cancer keratonicytes. Image: Queen Mary, University of London
London, UK (Scicasts) – Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early and late-stage oral and skin cancers, according to new research from scientists at Queen Mary, University of London.
In vitro tests showed omega-3 fatty acids induced cell death in malignant and pre-malignant cells at doses which did not affect normal cells, suggesting they have the potential to be used in both the treatment and prevention of certain skin and oral cancers. Omega-3 polyunsaturated fatty acids cannot be made by humans in large quantities and so we must acquire them from our diet.
दुबले आदमियों या दुबले लडकों या दुबली लड़्कियों या दुबली महिलाओं को आपने देखा होगा, कैसे लगते हैं देखने में ?
दुबले शरीर का होना अछ्छी बात है , एकहरा बदन हो तो यह बहुत अच्छा लगता है , फिल्मों के हीरो हीरोइनों को देखिये कोई भी आपको बहुत मोटा नही दिखाई देगा , सब इसीलिये अपने को maintain किये रहते हैं, किसलिये ?
आखिर छरहरा बदन भी कोई चीज होती है ? यही छरहरा बदन सब्को देखने मे अच्छा लगता है /
लेकिन अगर शरीर जरूरत से ज्यादा दुबला हो, skeleton जैसा दिखाई दे, तो फिर यह देखने वालों को अच्छा नही लगता /
आयुर्वेद में दुबले पतले लोगों के लिये महर्षि चरक ने लिखा है कि ” रूखा सूखा अन्न खाने वाले, अत्यधिक लन्घन यानी खाना या भोजन न खाने वाले, कम भोजन करने वाले, अधिक मेहनत करने वाले और कम खाना खाने वाले, ज्यादा जुलाब या enema…
Onion is a commonly known plant. The part used is the bulb, which grows underground. It is an essential part of our kitchen herbs and spices. Onion is used in lots of recipes all over the world particularly in South Asia. It is both herb and vegetable used in all seasons. It has been part of many herbal preparations particularly sexual medicines since ages due to its medical properties. Apart from the chemistry of onion, it has dry-warm characteristics, which are used to treat various ailments. It is a boon for those having wet-cold constitutions. Many diseases associated with wet-cold group can be treated with onion. In homeopathy it comes under the name Allium Cepa and is used for a multitude of symptoms. Following are some of the common uses: –
Asthma
Cholera
It is an excellent first aid for cholera. In most cases, a teaspoonful of onion juice can give immediate relief.
Diabetes Mellitus
Very useful in lowering the level of blood sugar.
In manufacturing, the oil is used to flavor foods.
How does it work?
Onion might help reduce cholesterol levels, a risk factor for hardening of the arteries. There is some evidence that onion might also reduce lung tightness in people with asthma.
MEDICINAL QUALITIES OF ONION
Research shows that onions may help guard against many chronic diseases. That’s probably because onions contain generous amounts of the flavonoid quercetin. Studies have shown that quercetin protects against cataracts, cardiovascular disease, and cancer. In addition, onions contain a variety of other naturally occurring chemicals known as organosulfur com-pounds that have been linked to lowering blood pressure and cholesterol levels.7Onions contain 25 active compounds that appear to inhibit the growth of cancerous cells alliin being the main constituent. Onion has been found to help combat heart disease, inhibit strokes, lower blood pressure and cholesterol, and stimulate the immune system. The potassium salts and the flavonoides that are present perform an anti-inflammatory action. The essential oil is an expectorant, antiseptic, antifungal, anticoagulant, high-blood pressure, antithelmitic, balsamic, rubefciant, and has analgesic properties
In investigating the use of onion in medicinal terms, the onion is found to be a remedy for conditions with symptoms like those which are caused by exposure to onions, such as watering eyes, and a burning and running nose. When looking at the symptoms of cold, it is ironic that we would treat this ailment with an almost like-with-like therapy. Alliums are antibacterial and anti-fungal, so they can help ward off colds and treat colds with sinus congestion that shifts from side to side in the head. Onion will relieve coughs that cause a ripping or tearing pain in the throat or a cough that is merely an irritating dry tickle. The watery and inflamed eyes due to sinus con-gestion and hay fever will be greatly relieved with onion.
The onions ability to relieve congestions especially in the lungs and bronchial tract, is hard to believe until you have actually witnessed the results. The drawing of infection, congestion and colds out of the ear is also remarkable.
The onion will relieve stomach upset and other gastrointestinal disorders and it will also strengthen the appetite.
Onions help prevent thrombosis and reduce hypertension, according to the American Heart Association. 8 The natural constituents of yellow or white onions can “…raise HDL cholesterol by 30% over time”, according to Dr. Victor Gurewich of Tufts University.9
The onion is being used for compresses to be applied to the skin for acne, arthritis, and congestion, and used internally for worms. The onion is also known for its diuretic properties.
There have been cases in which the onion has been proven to be so effective as an antiviral that a cut piece of onion placed in a closed off room will prevent the person in the room to be safe from viruses.
Onion will relieve headache centered behind the forehead; earache in children and adults; stuffed up nose with discharge that makes nostrils and upper lip sore or stuffed up nose with discharge from the alternate nostril; toothache, especially in the molar area or the shifting from side to side or from one tooth to another; hoarseness and the early stages of laryngitis; abdominal colic in babies.
Keeping cooler rooms in the home, and getting plenty of fresh air may prevent the symptoms of a stuffy nose and hoarseness
Never mind the tears they bring on—onions are an ace ally in your fight against disease. A prized member of the lily family, they lavish you with health benefits while adding oodles of taste to your food.
A quick glimpse at their incredible health benefits:
The phytochemicals in onions improve the working of Vitamin C in the body, thus gifting you with improved immunity.
Onions contain chromium, which assists in regulating blood sugar.
For centuries, onions have been used to reduce inflammation and heal infections.
Do you enjoy sliced onions with your food? If yes, rejoice! Raw onion encourages the production of good cholesterol (HDL), thus keeping your heart healthy.
A powerful compound called quercetin in onions is known to play a significant role in preventing cancer.
Got bitten by a honeybee? Apply onion juice on the area for immediate relief from the pain and burning sensation.
Onions scavenge free radicals, thereby reducing your risk of developing gastric ulcers.
Those bright green tops of green onions are rich in Vitamin A, so do use them often.
My favorite way to enjoy onions is to slice them really thin, squeeze some lemon juice on top and add a little salt. Sprinkling a few freshly washed cilantro leaves adds fragrance and flavor to this simple, quick salad, without which no dinner of mine is complete.
Yusuf Hamied made his name a decade ago when he faced down Big Pharma on patents for HIV/AIDS drugs and Cipla started selling them at a cost of about $1 a day. His disdain for what he considers Big Pharma’s “obscene prices” born out of monopolies is well documented. Hamied has the industry’s rapt attention again with his new attack on cancer meds and his avowal that Cipla will soon take on biologics.
Yusuf Khwaja Hamied is a leading Indian scientist and chairman of Cipla, a socially conscious generic pharmaceuticals company founded by his father Khwaja Abdul Hamiedin 1935.[2]
Born in Vilnius, Lithuania, Yusuf Hamied was raised in Bombay (now known as Mumbai). His Indian Muslim father and Russophone Jewish mother met in Berlin, where they both were graduate students. He holds a Ph.D. in chemistry from Christ’s College, Cambridge. He still uses his chemistry notebooks from Cambridge when he develops new syntheses of drugs.[3]
He is an alumnus of the Cathedral and John Connon School in Bombay. Affectionately called Yuku by his close friends, Hamied is fond of Western classical music and has been close friends with the world-famous conductor Zubin Mehta since boyhood.
Hamied has led efforts to eradicate AIDS in the developing world and to give patients life-saving medicines regardless of their ability to pay,[4] and has often been characterized as a modern-day Robin Hood figure[5][6][7][8] as a result.
Former head of Johnson and Johnson Ajit Dangi says plainly “In Africa, Cipla is a temple and Dr. Hamied is God.” [9] To this Hamied has countered “I don’t want to make money off these diseases which cause the whole fabric of society to crumble”. [10]
In September 2011, in a piece about how he was trying to radically lower costs of biotech drugs for cancer, diabetes and othernoncommunicable diseases, The New York Times wrote of Hamied:
Dr. Yusuf K. Hamied, chairman of the Indian drug giant Cipla Ltd., electrified the global health community a decade ago when he said he could produce cocktails of AIDS medicines for $1 per day — a fraction of the price charged by branded pharmaceutical companies. That price has since fallen to 20 cents per day, and more than six million people in the developing world now receive treatment, up from little more than 2,000 in 2001.[11]
Yusuf Hamied has also been enormously influential in pioneering development of multi-drug combination pills (also known as fixed-dose combinations, or FDCs), notably for HIV/AIDS, tuberculosis (TB), asthma and other ailments chiefly affecting developing countries, as well as development of pediatric formulations of drugs, especially those benefiting children in poor settings.[12] These innovations have greatly expanded access to medicine and increased drug safety by ensuring proper dosages are taken. He is also highly regarded for his leading role in expanding the production of bulk drugs and “active pharmaceutical ingredients” (APIs, the active chemical components in medicines) in India.[13]
Yusuf Hamied has been the subject of in-depth profiles in The New York Times, Time magazine, The Guardian, Le Monde, The Economist, the Financial Times, The Times (London), Corriere della Sera, Der Spiegel, Wired and numerous other leading publications, as well as on television outlets such as ABC News, the BBC, CNN and CBS’ 60 Minutes.
Yusuf Hamied was awarded the ‘Indian Of The Year’ in the category of business by CNN-IBN in 2012.[15]
Cdiffense trial to evaluate vaccine against a leading cause of life-threatening, healthcare-associated infections worldwide
SWIFTWATER, Pa., Aug. 5, 2013 /PRNewswire/ — Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: SAN and NYSE: SNY), announced today the initiation of its Phase III clinical program called Cdiffense to evaluate the safety, immunogenicity and efficacy of an investigational vaccine for the prevention of primary symptomatic Clostridium difficile infection (CDI). Clostridium difficile (C. diff) is a potentially life-threatening, spore-forming bacterium that causes intestinal disease. The risk of C. diff increases with age, antibiotic treatment and time spent in hospitals or nursing homes, where multiple cases can lead to outbreaks. The investigational vaccine is designed to help protect at-risk individuals from C. diff, which is emerging as a leading cause of life-threatening, healthcare-associated infections (HAIs)worldwide, read all at…………….
Bristol, UK (Scicasts) – New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.
The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry August 2 show that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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New Drug Approvals 