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FLOW SYNTHESIS IN ACTION

October 25, 2014 11:24 am


 

 

 

Multi-step synthesis using modular flow reactors: the preparation of yne-ones and their use in heterocycle synthesis

I.R. Baxendale, S.C. Schou, J. Sedelmeier, S.V. Ley, Chem. Eur. J. 2010, 16, 89-94.

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http://onlinelibrary.wiley.com/doi/10.1002/chem.200902906/abstract

http://onlinelibrary.wiley.com/store/10.1002/chem.200902906/asset/supinfo/chem_200902906_sm_miscellaneous_information.pdf?v=1&s=e659fdc2121b72d28f3caeea481a89cc3278bc01

 

Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne[BOND]ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).

 

 

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Posted by DR ANTHONY MELVIN CRASTO Ph.D

Categories: organic chemistry

Tags: , , ,

2 Responses to “FLOW SYNTHESIS IN ACTION”

  1. Reblogged this on ORGANIC CHEMISTRY SELECT.

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    By DR ANTHONY MELVIN CRASTO Ph.D on October 25, 2014 at 11:36 am

  2. Reblogged this on SynthFlow and commented:
    Addition from New Drug Approvals — flow chemistry in action

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    By totallymicrowave on October 25, 2014 at 1:43 pm

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