New Drug Approvals
Home | Pages | Archives
THE GROWING IMPACT OF CLICK CHEMISTRY ON DRUG DISCOVERY
August 16, 2014 3:37 am
HC Kolb, KB Sharpless – Drug discovery today, 2003 – Elsevier
Click chemistry is a modular approach that uses only the most practical and reliable
chemical transformations. Its applications are increasingly found in all aspects of drug
discovery, ranging from lead finding through combinatorial chemistry and target-templated …
Click chemistry is a modular approach that uses only the most practical
and reliable chemical transformations. Its applications are increasingly
found in all aspects of drug discovery, ranging from lead finding through
combinatorial chemistry and target-templated in situchemistry, to proteomics
and DNA research, using bioconjugation reactions. The copper-(I)-catalyzed
1,2,3-triazole formation from azides and terminal acetylenes is a particularly
powerful linking reaction, due to its high degree of dependability, complete
specificity, and the bio-compatibility of the reactants. The triazole products
are more than just passive linkers; they readily associate with biological
targets, through hydrogen bonding and dipole interactions.
GET YOUR PDF AT
http://image.sciencenet.cn/olddata/kexue.com.cn/blog/admin//images/upfiles/2007101622257911935.pdf
Posted by DR ANTHONY MELVIN CRASTO Ph.D
Categories: Drug discovery
Tags: CLICK CHEMISTRY, drug discovery
« Older Newer »
Leave a Reply
Mobile Site | Full Site
Get a free blog at WordPress.com Theme: WordPress Mobile Edition by Alex King.
Reblogged this on Pharmaceutical Intelligence and commented:
DR ANTHONY MELVIN CRASTO, Worlddrugtracker, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India, in Organic chemistry,
The growing impact of click chemistry on drug discovery
HC Kolb, KB Sharpless – Drug discovery today, 2003 – Elsevier
[PDF] from sciencenet.cn
LikeLike
By larryhbern on August 16, 2014 at 7:38 pm