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DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 36Yrs Exp. in the feld of Organic Chemistry,Working for AFRICURE PHARMA as ADVISOR earlier with GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, NO ADVERTISEMENTS , ACADEMIC , NON COMMERCIAL SITE, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution, ........amcrasto@gmail.com..........+91 9323115463, Skype amcrasto64 View Anthony Melvin Crasto Ph.D's profile on LinkedIn Anthony Melvin Crasto Dr.

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with AFRICURE PHARMA, ROW2TECH, NIPER-G, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India as ADVISOR, earlier assignment was with GLENMARK LIFE SCIENCES LTD, as CONSUlTANT, Retired from GLENMARK in Jan2022 Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 32 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 32 PLUS year tenure till date Feb 2023, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 100 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 100 Lakh plus views on dozen plus blogs, 227 countries, 7 continents, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 38 lakh plus views on New Drug Approvals Blog in 227 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc He has total of 32 International and Indian awards

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Recent Posts

Fasting for three days can regenerate entire immune system, study finds


Lyranara.me's avatarLyra Nara Blog

Fasting for as little as three days can regenerate the entire immune system, even in the elderly, scientists have found in a breakthrough described as “remarkable”.

Although fasting diets have been criticised by nutritionists for being unhealthy, new research suggests starving the body kick-starts stem cells into producing new white blood cells, which fight off infection.

Scientists at the University of Southern California say the discovery could be particularly beneficial for people suffering from damaged immune systems, such as cancer patients on chemotherapy.

It could also help the elderly whose immune system becomes less effective as they age, making it harder for them to fight off even common diseases.

The researchers say fasting “flips a regenerative switch” which prompts stem cells to create brand new white blood cells, essentially regenerating the entire immune system.

“It gives the ‘OK’ for stem cells to go ahead and begin proliferating and rebuild the…

View original post 575 more words

Tie up with Emcure…..Roche to launch cheaper cancer drugs in India


Reuters | Updated On: June 06, 2012 12:36 (IST)

Mumbai:

Swiss drugmaker Roche Holding AG plans to offer cut-price versions of two blockbuster cancer drugs for the Indian market soon, a company spokesman said on Friday, days after New Delhi moved to slash the price of a rival cancer treatment.

 

India stripped German’s Bayer AG of its exclusive rights to Nexavar earlier this month and licensed a local drugs company to produce a cheap, generic version, on the grounds that poor Indians could not otherwise afford the life-saving drug.

 

Roche, the world’s biggest maker of cancer drugs, said it would offer “significantly” cheaper, locally branded versions of its two cancer drugs, Herceptin and MabThera, by early next year, under an alliance with India’s Emcure Pharmaceuticals Ltd.

 

http://profit.ndtv.com/news/corporates/article-roche-to-launch-cheaper-cancer-drugs-in-india-300344

Russian scientists create cancer cure that doubles life span


Lyranara.me's avatarLyra Nara Blog

Russian scientists create cancer cure that doubles life span

Scientists in the Russian city of Novosibirsk have created a vaccine that can double a cancer patient’s life expectancy. The drug has already been tested clinically and may soon appear in stores.

When given to patients suffering from the third and fourth stage of colorectal, breast and prostate cancer, the treatment can significantly prolong their life span, says Vladimir Kozlov, the head of the Clinical Immunology Institute that did the research.

The vaccine is extracted from the dendritic cells, which are immune cells producing antigen material. The patient’s dendritic cells are then altered with the tumor cell culture and injected into the organizm, triggering an immune response, which means they attack cancer.

The treatment is now available to people after a cancer surgery, although scientists envisage the drug would be able to cure cancer in the early stages.

View original post

New therapy wipes out cervical cancer in two women


Lyranara.me's avatarLyra Nara Blog

Aricca Wallace knew she was nearly out of time. For more than three years, she had suffered cramping and irregular bleeding, which her doctor thought was a side effect of her birth control implant, known as an intrauterine device, or IUD. Her annual Pap smears were always normal, so no one suspected cancer.

Except it was cancer, and by the time the 34-year-old mother of two had the IUD removed and was finally diagnosed, her tumors had reached stage three and the disease was spreading through the lymph nodes in her abdomen and chest.

“I was told by a specialist that there wasn’t any chemo that could kill it,” Wallace told AFP. “And that I’d be gone in a year.”

That was in February 2012. A few months later, Wallace’s doctor told her about an immunotherapy trial at the National Institutes of Health Clinical Center, a research hospital just outside the…

View original post 646 more words

Hey, did you consider the impact of waste disposal as part of the cost of your API synthesis ?


developingtheprocess's avatarDeveloping the Process

Hi Everyone, I want to thank Chemjobber for the renewed interest in an article I posted a while back.  The posting was about selecting solvents, my post was “Which solvent should I choose ?”, referring to an article that was  published by some colleagues at GSK, Green Chem., 2011,13, 854-862, DOI: 10.1039/c0gc00918k.  I have an article that is somewhat related to picking solvents in my current grab-bag of chemical literature.

I have to admit that it never crossed my mind to figure out how I was going to dispose of the chemical waste my reactions were generating.  Health & Safety comes by and disposed of my chemical waste.  I think that there is a movement to introduce some self-consciousness in the chemistry we are using and part of this responsibility is to consider what impact we have on the environment (did I dare say that ?)  …

View original post 272 more words

E.T.G. AyurvedaScan CONTINUOUS TRACE RECORD TEST RESULTS ; FEW ILLUSTRATION OF CASES


Dr.D.B.Bajpai's avatar**आधुनिक युग आयुर्वेद ** ई०टी०जी० आयुर्वेदास्कैन ** DIGITAL AYURVEDA TRIDOSHO SCANNER**AYURVED H. T. L. WHOLE-BODY SCANNER**आयुषव्यूज रक्त केमिकल केमेस्ट्री परीक्षण अनालाइजर ** डिजिटल हैनीमेनियन होम्योपैथी स्कैनर **

NEW INVENTION of ETG AyurvedaScan system have now introduced “continuous test” of the organs or viscera affected for their minute patho-physiological and pathological studies for diagnosis and other purposes.

Below is given three patient’s traces , which was recorded at least 04 hours continuously for best diagnosis and pin-point problem solutions.

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E.T.G. AyurvedaScan CONTINUOUS TRACE RECORDING SYSTEM  provides regular monitoring of the affected area or patient problems diagnosis and to know , what is happening with the  patient within 24 hours or within 48 hours oe more , may be  monitorised by this system. 

Many patient complaints that they feel problems at any hours of the day or night , for them this process is beneficial to trace the problems they have.

Few hours like 3 to 4 hours continuous monitoring is also beneficial for short term observations. These observations are beneficial for treatment and management of…

View original post 139 more words

Autism linked to ‘male hormones’


atasteofcreole's avatarAtasteofcreole's Blog

http://www.bbc.com/news/health-27662080

Exposure to high levels of “male” hormones in the womb increases the chance of a baby boy developing autism, according to researchers.

The University of Cambridge researchers say their findings from more than 300 boys help unravel the causes of autism – a condition that affects both sexes but is far more common in males.

But they say it does not mean a prenatal test for autism is near.

Nor will it necessarily be possible to stop autism by blocking the hormones.

“Because some of these hormones are produced in much higher quantities in males than in females, this may help us explain why autism is more common in males”  –  Prof Baron-Cohen Study author

The hormones in question – testosterone and three other steroid hormones – were important for foetal development, which meant it could be too risky to block them, they told the journal Molecular Psychiatry.

Autism…

View original post 435 more words

A New Approach for Heart Disease: G Strophantin


Lyranara.me's avatarLyra Nara Blog

Coronary artery disease is currently the leading cause of death in the United States. Despite the increasing sophistication of surgical techniques, the introduction of new techniques such as balloon angioplasty, and a number of new drugs (e.g. beta blockers, calcium antagonists), it is estimated that over 1 million heart attacks will occur this year, resulting in 500,000 deaths. In short, we do not have an adequate therapeutic solution to the problem of myocardial infarction (heart attack).

The cornerstone of therapy for treatment and prevention of myocardial infarction is to remove blockages in coronary arteries that are thought to be the cause of the infarction. This adheres to the widely accepted coronary artery thrombosis theory of infarction; that is, arteries become clogged with plaque, damaged from such things as smoking or high cholesterol. A clot forms a fissure in the plaque. The clot may shut off the blood flow of the…

View original post 1,784 more words

Billions and billions…of molecules?


Billions and billions…of molecules? 

 

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Billions and billions…of molecules?

I’ve written about the CAS Registry – the enormous database of small and large molecules – on several occasions over my quarter of a century in science communication. It usually comes up when they reach a milestone. Indeed, I remember writing about the day they registered their 10 millionth structure, that was either in The Guardian or New Scientist, don’t remember, it was the early 1990s. I wrote about it much more recently here on the Sciencebase blog back in September 2009 when they reached 50 million structures. How can there be so many chemicals, surely we are approaching some kind of limit? Well, no. We are nowhere near

 

READ

http://life-sciences.blognotions.com/2014/05/19/billions-and-billionsof-molecules/?_m=3l%2e000r%2e34%2ecq0akw6mcb%2e1zb

How to document a Product Transfer? Example templates!


 How to document a Product Transfer? Example templates!
All participants of the GMP training course “GMP-compliant Product Transfer” will receive a special version of the Guideline Manager CD including documents immediately useable for planning and documenting a site change. Read more.

http://www.gmp-compliance.org/eca_mitt_4328_8427,8526_n.html

How to document a Product Transfer? Example templates!

After the changes in chapter 4 of the EU GMP Guide have become effective, written procedures and documentation of the transfer activities are required. For example, a Transfer SOP, transfer plan and report have become mandatory this way.

As a participant of the GMP education course “GMP-compliant Product Transfer” in Prague, from 7-9 October 2014 you will receive a special version of the Guideline Manager CD with a special section concerning product transfers. This section contains, amongst others, a Transfer SOP and a template for a Transfer Plan. Both documents are in Word format and can immediately be used after adoption to your own situation.

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I , Dr A.M.Crasto is writing this blog to share the knowledge/views, after reading Scientific Journals/Articles/News Articles/Wikipedia. My views/comments are based on the results /conclusions by the authors(researchers). I do mention either the link or reference of the article(s) in my blog and hope those interested can read for details. I am briefly summarising the remarks or conclusions of the authors (researchers). If one believe that their intellectual property right /copyright is infringed by any content on this blog, please contact or leave message at below email address amcrasto@gmail.com. It will be removed ASAP