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Octamoxin, октамоксин , أوكتاموكسين , 奥他莫辛 ,

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Octamoxin

Skeletal formula of octamoxin

Octamoxin
  • Molecular FormulaC8H20N2
  • Average mass144.258 Da
Octan-2-ylhydrazine
Octomoxine
UNII:0HXY3M6S54
UNII:2NJ66SLA5C
UNII:895PL98ZMY
4684-87-1 [RN]
65500-65-4 [RN]
895PL98ZMY
0HXY3M6S54
1776
2-Hydrazinooctane
2NJ66SLA5C
CAS Registry Number: 4684-87-1
CAS Name: (1-Methylheptyl)hydrazine
Additional Names: 2-hydrazinooctane; octomoxine
Trademarks: Ximaol
Molecular Formula: C8H20N2
Molecular Weight: 144.26
Percent Composition: C 66.61%, H 13.97%, N 19.42%
Literature References: Monoamine oxidase inhibitor. Prepd by condensation of methyl hexyl ketone and hydrazine hydrate followed by hydrogenation under pressure: Michel-Ber et al., GB 899385 (1962 to Soc. Civile Auguil).
Derivative Type: Sulfate
CAS Registry Number: 3845-07-6
Trademarks: Nimaol
Molecular Formula: C8H20N2.H2SO4
Molecular Weight: 242.34
Percent Composition: C 39.65%, H 9.15%, N 11.56%, S 13.23%, O 26.41%
Properties: Crystals, mp 78-80°.
Melting point: mp 78-80°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Hydrazides/Hydrazines; Monoamine Oxidase Inhibitor.
Octamoxin (trade names XimaolNimaol), also known as 2-octylhydrazine, is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant in the 1960s but is now no longer marketed.[2][3][4][5]
CLIP
OXIME TO AMINO TO PRODUCT
Kishner, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva1899vol. 31p. 878Ch emisches Zentralblatt 1900 vol. 71 Ip. 653

References

  1. ^ “Octamoxin – Compound Summary”. USA: National Center for Biotechnology Information. 26 March 2005. Identification and Related Records. Retrieved 31 May 2012.
  2. ^ “Dictionary of pharmacological agents – Google Books”.
  3. ^ “13-06781. Octamoxin [Archived]: The Merck Index”.
  4. ^ Levy J, Michel-Ber E (1966). “[Relations between the antidepressive effects of octamoxine revealed by 3 pharmacological tests and inhibition of cerebral monoamine oxidase in mice]”. Thérapie (in French). 21 (4): 929–45. PMID 5925088.
  5. ^ Gayral L, Stern H, Puyuelo R (1966). “[Indications and results of the treatment of mental depression by octamoxine (ximaol)]”. Thérapie (in French). 21 (5): 1183–90. PMID 5976767.
Octamoxin
Skeletal formula of octamoxin
Names
Preferred IUPAC name

1-Methylheptylhydrazine[citation needed]
Systematic IUPAC name

Octan-2-ylhydrazine[1]
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
UNII
Properties
C8H20N2
Molar mass 144.262 g·mol−1
Density 0.831 g/mL
Boiling point 228 °C (442 °F; 501 K)
Pharmacology
Oral
Related compounds
Related compounds
Tuaminoheptane
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
///////////Octamoxin, XimaolNimaol,  2-octylhydrazine, октамоксин أوكتاموكسين 奥他莫辛 ,
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DR ANTHONY CRASTO

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DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO Ph.D

DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 30 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. Radhakrishnan and Dr B. K. Kulkarni, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 30 year tenure till date Dec 2017, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 50 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email amcrasto@gmail.com, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 19 lakh plus views on New Drug Approvals Blog in 216 countries......https://newdrugapprovals.wordpress.com/ , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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