DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO
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BTI-320 (formerly PAZ320)
PAZ 320
Non-insulin dependent diabetes
Alpha-glucosidase inhibitor; Hydrolase inhibitor; Sucrose alpha-glucosidase inhibitor
Composition of chemically purified (fractionation) soluble mannan polysaccharides from legume’s seeds
BTI-320 is in phase II clinical development at Boston Therapeutics for the treatment of type 2 diabetes in combination with oral agents or insulin, and also for the treatment of high-risk patients with pre-diabetes. A chewable tablet formulation is being developed. The product is already available as dietary supplement.
| Company | Boston Therapeutics Inc. |
| Description | Chewable polysaccharide that inhibits alpha glucosidase |
| Molecular Target | |
| Mechanism of Action | Alpha glucosidase inhibitor |
| Therapeutic Modality | Macromolecule: Polysaccharide |
| Latest Stage of Development | Phase II |
| Standard Indication | Diabetes |
| Indication Details | Treat Type II diabetes |
PATENT
http://www.google.co.in/patents/WO2012061675A1?cl=en
A composition of chemically purified soluble mannans from legumes’ seeds (e.g. Ceratonia siliqua, Cæsalpinia spinosa Trigonelle foenum-graecum, and Cyamopsis tetragonolobus) and their use in the assembly of palatable dietary supplements is disclosed herein. The fractionation process provides high-quality physiologically soluble, chemically modified and purified homogeneous size polysaccharide fibers, devoid of natural impurities, for example proteins, alkaloids, glycoalkaloids, and/or environmental impurities including heavy metals, agricultural residues and microbial toxins. This process provides hypoallergenic dietary fibers devoid of any potential allergens, cytotoxins, and gastrointestinal toxins. A sequential process for assembly of the soluble fibers with plurality of molecular weights to create a time controlled dissolution of the functional high and low molecular weight fibers for improving solubility and palatability with improved dietary performance in the oral and gastro-intestinal system is also disclosed herein.
Fig. 1 illustrates a block flow diagram of an embodiment of a method for recovering purified mannan polysaccharides;
Fig. 2 illustrates a chemical structure of a mannan polysaccharide;
Fig. 3 illustrates a block flow diagram of an embodiment of a method for recovering high molecular weight (HMW) purified mannan polysaccharides;
Fig. 4 illustrates a block flow diagram of an embodiment of a method for recovering low molecular weight (LMW) purified mannan polysaccharides;
REFERENCES
https://clinicaltrials.gov/show/NCT02060916
https://clinicaltrials.gov/show/NCT02358668
BTI-320, a nonsystemic novel drug to control glucose uptake into the bloodstream, functions as a competitive inhibitor of sugar hydrolyzing enzymes
75th Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 5-9, Boston) 2015, Abst 974-P
Boston Therapeutics’ Hong Kong Affiliate Advance Pharmaceutical’s BTI-320 Clinical Trial Reaches Mid-Point by Enrolling 30 Patients at the Chinese University of Hong Kong
Boston Therapeutics Press Release 2015, July 08
Insight into the molecular mechanism of action of BTI320, a non-systemic novel drug to control serum glucose levels in individuals with diabetes50th Annu Meet Eur Assoc Study Diabetes (EASD) (September 15-19, Vienna) 2014, Abst 545
////BTI-320, PAZ320, PHASE 2, BTI 320, PAZ 320, Macromolecule, Polysaccharide, Non-insulin dependent diabetes, Alpha-glucosidase inhibitor, Hydrolase inhibitor, Sucrose alpha-glucosidase inhibitor, phase II clinical development, Boston Therapeutics, Soluble mannan polysaccharides
Composition of chemically purified (fractionation) soluble mannan polysaccharides from legume’s seeds
POLYMER OF BELOW
CAS 9036-88-8, 51395-96-1
| refractive index : | 78.5 ° (C=1.4, H2O) |
Ailes;MANNAN;K-41K1;D-Mannan;NSC 174478;NSC 174479;NSC 174481;NSC 307194;NSC 174477;NSC 174473
| Chemical name: | 1,6-Anhydro-β-D-mannopyranose |
| Synonyms: | 1,6-Anhydro-D-mannose; 1,6-Anhydromannose; Mannosan; NSC 226600; |
| CAS Number: | 14168-65-1 |
| Possible CAS #: | NA |
| Molecular form.: | C₆H₁₀O₅ |
| Appearance: | White to Pale Beige Solid |
| Melting Point: | 182-184°C |
| Mol. Weight: | 162.14 |
Summary:
Mannans are major constitutents of hemicelluloses in plant tissue and are polymers composed of β(1→4)-linked mannose and glucose residues. Some contain galactopyranosyl side chains (see a galactomannan).
Slightly galactosylated mannans (4% galactose), considered as linear β(1→4)-D-mannans, have been isolated from the seed endosperm of vegetable ivory nut ( Phytelephas macrocarpa) and date ( Phoenix dactylifera) .
Glycan icon:
Child Classes: a 1,6-α-D-mannan backbone (0), a galactoglucomannan (0), a galactomannan (0), a glucomannan (0), a mannan oligosaccharide (1)
SMILES: C(O)C4(C(O[R1])C(O)C(O)C(OC3(C(O)C(O)C(OC2(C(O)C(O)C(OC1(C(O)C(O)C(O[R2])OC(CO)1))OC(CO)2))OC(CO)3))O4)
CAS:9036-88-8,
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