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HSP70i, A genetically modified protein, on Experimental Vitiligo Treatment, Shows Promise in Mice



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WEDNESDAY Feb. 27, 2013 — A genetically modified protein could provide the first effective treatment for the skin condition vitiligo, a new study in mice suggests.

People with vitiligo have white patches on the face, hands and other parts of the body. Vitiligo is an autoimmune disorder in which the immune system becomes overactive and kills the pigment cells that give skin its color.

Researchers at the Loyola University Chicago Stritch School of Medicine developed a genetically modified protein that reversed vitiligo in mice and had similar effects on human skin tissue samples. Findings from animal studies do not always hold up in human trials, however.

A protein called HSP70i plays a major role in the autoimmune response that causes vitiligo. The researchers genetically modified an amino acid in the protein in order to create a mutant version of HSP70i. This version replaces normal HSP70i and reverses the autoimmune response that causes vitiligo, the study authors explained in a Loyola news release.

When the mutant HSP70i was given to mice with vitiligo, their salt-and-pepper fur turned black, giving them a normal appearance. The mutant protein had a similar effect on human skin samples, according to the study, published in the current issue of the journal Science Translational Medicine.

Researcher I. Caroline Le Poole, a professor in Loyola’s Oncology Institute, and colleagues are seeking approval and funding to conduct a clinical trial of the modified protein in humans.

About 1 million Americans have vitiligo, which affects about one in 200 people worldwide. There are no long-term effective treatments for the condition. Current options include steroid creams, light therapy and skin grafts, but none of them can prevent vitiligo from progressing.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about vitiligo.


  1. shahbaz shaikh says:

    i am suffering from vitiligo from last 5 yrs please suggest me any treatment available in HSP70i available in india

  2. vinod pawde says:

    i am suffering from vitiligo prob from last 10 this HSP70i available in india.if available then locate city.

  3. ketan says:

    I am already suffering from this disease since 20 year. My diseases (vittiligo) only on both finger of hand & ankle joint.if any effective treatment in India please send me mail on my mail id.thank’s.

  4. humankindest says:

    kindly provide this medicine to oll over world , each corner of the world so that no body suffer from this chronical disease , and permanently cured by this medicine as other disese can easlily cured…. plz bring this product into the market,,, indian dermatologist kindly pay attention towards this discovery…..plz

  5. adam espinosa says:

    I have just recently got this been with bout 8 months now would like try any possible cure

  6. Almhec says:

    I was checking this site that has a lot of information about the vitiligo but where exactly can we find the product? from which companies? with which names this hsp70i is sold to the public on stores?

  7. Anthony says:


    This is not yet ready anywhere in the world, they first have to get approved for human clinical trials then FDA approval,unfortunatley that coyld take anywhere between 1-3 years. I personally would travel across the world if its avaible sooner in other parts of the world. Also incase you may not know but there is another promising procedure in the U.K called re-cell performed at the Nothingham clinic by Dr.Maini. Its rather expensive though. You can google Avita Recell for more information on the product.

  8. Mahesh says:

    Hi All,
    Are there any food; vegetable, fruit, meat or product that contain hsp70i?

  9. alessandro says:

    re cell dose not work I have try it it cost 5000 aud and no sucsess your vitiligo save your money and where they took the skin from it is now depigmented aswell applied57@

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DR ANTHONY MELVIN CRASTO, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his Ph.D from ICT, 1991,Matunga, Mumbai, India, in Organic Chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK PHARMACEUTICALS LTD, Research Centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Total Industry exp 30 plus yrs, Prior to joining Glenmark, he has worked with major multinationals like Hoechst Marion Roussel, now Sanofi, Searle India Ltd, now RPG lifesciences, etc. He has worked with notable scientists like Dr K Nagarajan, Dr Ralph Stapel, Prof S Seshadri, Dr T.V. Radhakrishnan and Dr B. K. Kulkarni, etc, He did custom synthesis for major multinationals in his career like BASF, Novartis, Sanofi, etc., He has worked in Discovery, Natural products, Bulk drugs, Generics, Intermediates, Fine chemicals, Neutraceuticals, GMP, Scaleups, etc, he is now helping millions, has 9 million plus hits on Google on all Organic chemistry websites. His friends call him Open superstar worlddrugtracker. His New Drug Approvals, Green Chemistry International, All about drugs, Eurekamoments, Organic spectroscopy international, etc in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 30 year tenure till date Dec 2017, Around 35 plus products in his career. He has good knowledge of IPM, GMP, Regulatory aspects, he has several International patents published worldwide . He has good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, Polymorphism etc., He suffered a paralytic stroke/ Acute Transverse mylitis in Dec 2007 and is 90 %Paralysed, He is bound to a wheelchair, this seems to have injected feul in him to help chemists all around the world, he is more active than before and is pushing boundaries, He has 9 million plus hits on Google, 2.5 lakh plus connections on all networking sites, 50 Lakh plus views on dozen plus blogs, He makes himself available to all, contact him on +91 9323115463, email, Twitter, @amcrasto , He lives and will die for his family, 90% paralysis cannot kill his soul., Notably he has 19 lakh plus views on New Drug Approvals Blog in 216 countries...... , He appreciates the help he gets from one and all, Friends, Family, Glenmark, Readers, Wellwishers, Doctors, Drug authorities, His Contacts, Physiotherapist, etc

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