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H7N9 vaccines in development–where are we?



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influenza h7n9 vaccine development (Photo Credit: CDC/Cynthia S. Goldsmith and Thomas Rowe)

Since early 2013, the newly emergent H7N9 avian influenza virus has been infecting humans in China, leading to the temporary closure of numerous poultry markets in a bid to control the outbreak. In recent weeks, the rate at which new cases are reported has been declining – but some experts are asking whether this is just the calm before the storm. The development of a vaccine against the virus is therefore still of great interest – but where are we with vaccine development?

Inovio Pharmaceuticals announced on July 8th that in a preclinical study of its influenza DNA vaccine, 100% of the vaccinated animals were protected against sickness and death when challenged with a lethal dose of A/Anhui/1/13 strain of H7N9 virus. On the same day, Novavax made an announcement that enrolment had begun for a Phase I clinical trial of its monovalent virus-like particle (VLP) vaccine candidate – again based on the A/Anhui/1/13 strain

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DR ANTHONY MELVIN CRASTO, Worlddrugtracker, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India, in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARK- GENERICS LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now sSanofi, Searle India ltd, now Rpg lifesciences, etc. he is now helping millions, has million hits on google on all organic chemistry websites. His New Drug Approvals, Green Chemistry International, Eurekamoments in organic chemistry are some most read blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 25 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has several international drug patents published worldwide . He gas good proficiency in Technology transfer, Spectroscopy, Stereochemistry, Synthesis, polymorphism etc He suffered a paralytic stroke in dec 2007 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has one lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, amcrasto@gmail.com

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